creatine + ATP => phosphocreatine + ADP [CKB,CKM]

Stable Identifier
R-HSA-200318
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Cytosolic creatine kinase catalyzes the reaction of creatine and ATP to form phosphocreatine and ADP. The active form of the enzyme is a dimer. Monomers of the cytosolic enzyme occur in two isoforms, B and M, so called because of their abundance in brain and muscle respectively. The enzyme is widely expressed in the body and many tissues express both isoforms. Both homo- (BB, MM) and heterodimers (BM) are catalytically active.

Literature References
PubMed ID Title Journal Year
16981706 Exploring the role of the active site cysteine in human muscle creatine kinase

Wang, PF, Flynn, AJ, Naor, MM, Jensen, JH, Cui, G, Merz KM, Jr, Kenyon, GL, McLeish, MJ

Biochemistry 2006
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
creatine kinase activity of CKB, CKM [cytosol]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Created