creatine + ATP => phosphocreatine + ADP [CK octamer]

Stable Identifier
R-HSA-200326
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Creatine kinase octamers associated with the inner mitochondrial membrane catalyze the reaction of creatine and ATP to form phosphocreatine and ADP. Two mitochondrial creatine kinase proteins have been identified, one encoded by CKMT1A and B that is found in many tissues and one encoded by CKMT2 that is found in sarcomeres (Haas et al. 1988; Haas and Straus 1990). Studies of sarcomeric creatine kinase octamers suggest that their organization and association with phospholipids in the inner mitochondrial membrane may facilitate energy transfer from ATP generated in the mitochondrial matrix to cytosolic phosphocreatine (Khuchua et al. 1998; Schlattner et al. 2004).

Literature References
PubMed ID Title Journal Year
15044463 C-terminal lysines determine phospholipid interaction of sarcomeric mitochondrial creatine kinase

Schlattner, U, Gehring, F, Vernoux, N, Tokarska-Schlattner, M, Neumann, D, Marcillat, O, Vial, C, Wallimann, T

J Biol Chem 2004
2324105 Separate nuclear genes encode sarcomere-specific and ubiquitous human mitochondrial creatine kinase isoenzymes

Haas, RC, Strauss, AW

J Biol Chem 1990
9722522 Octamer formation and coupling of cardiac sarcomeric mitochondrial creatine kinase are mediated by charged N-terminal residues

Khuchua, ZA, Qin, W, Boero, J, Cheng, J, Payne, RM, Saks, VA, Strauss, AW

J Biol Chem 1998
2914937 Isolation and characterization of the gene and cDNA encoding human mitochondrial creatine kinase

Haas, RC, Korenfeld, C, Zhang, Z, Perryman, B, Roman, D, Strauss, AW

J Biol Chem 1989
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
creatine kinase activity of CK octamers [mitochondrial inner membrane]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Created