Creatine transport across the plasma membrane

Stable Identifier
R-HSA-200396
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The SLC6A8 transport protein associated with the plasma membrane mediates the uptake of extracellular creatine and a sodium ion (Sora et al. 1994). Molecular and biochemical studies of patients deficient in SLC6A8 protein confirm this function in vivo (e.g., Salomons et al. 2003).

Literature References
PubMed ID Title Journal Year
7945388 The cloning and expression of a human creatine transporter

Sora, I, Richman, J, Santoro, G, Wei, H, Wang, Y, Vanderah, T, Horvath, R, Nguyen, M, Waite, S, Roeske, WR, Yamamura, HI

Biochem Biophys Res Commun 1994
12889669 X-linked creatine transporter defect: an overview

Salomons, GS, van Dooren, SJ, Verhoeven, NM, Marsden, D, Schwartz, C, Cecil, KM, DeGrauw, TJ, Jakobs, C

J Inherit Metab Dis 2003
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
creatine:sodium symporter activity of SLC6A8-like proteins [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Created