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PRKAB2 [cytosol]
Stable Identifier
R-HSA-200411
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
PRKAB2 active conformation, AMPK beta 2 (active)
Icon
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Fatty acid metabolism (Homo sapiens)
Carnitine metabolism (Homo sapiens)
pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis (Homo sapiens)
AMPK heterotrimer (active) [cytosol] (Homo sapiens)
PRKAB2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O43741 PRKAB2
Gene Names
PRKAB2
Chain
chain:1-272
Reference Genes
BioGPS Gene:5565 PRKAB2
COSMIC (genes):PRKAB2 PRKAB2
CTD Gene:5565 PRKAB2
dbSNP Gene:5565 PRKAB2
ENSEMBL:ENSG00000131791 PRKAB2
HGNC:9379 PRKAB2
KEGG Gene (Homo sapiens):5565 PRKAB2
Monarch:5565 PRKAB2
NCBI Gene:5565 PRKAB2
OMIM:602741 PRKAB2
UCSC:O43741 PRKAB2
Reference Transcript
RefSeq:NM_005399.4 PRKAB2
Other Identifiers
0005700671
11718956_a_at
11718957_at
11718958_s_at
1558027_s_at
16692297
214474_at
225278_at
2433210
2433211
2433212
2433213
2433216
2433217
2433219
2433220
2433221
2433224
2433225
36705_at
51254_at
5565
78707_at
7919305
A_23_P350704
A_24_P105564
A_24_P917711
GE55250
GO:0003674
GO:0004679
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006464
GO:0006468
GO:0006629
GO:0006631
GO:0006633
GO:0006810
GO:0006853
GO:0006914
GO:0007049
GO:0007050
GO:0007165
GO:0008150
GO:0009056
GO:0009058
GO:0016236
GO:0016241
GO:0016301
GO:0019899
GO:0019901
GO:0031588
GO:0032991
GO:0042304
GO:0042592
GO:0042802
GO:0043226
GO:0044281
GO:0050790
GO:0055085
GO:0120162
GO:1901796
Hs.35304.0.S1_3p_at
Hs.50732.0.S1_3p_at
Hs2.399853.1.S1_3p_s_at
ILMN_1786021
PH_hs_0003495
TC01003124.hg
Participant Of
hasComponent
AMPK heterotrimer (active) [cytosol]
Other forms of this molecule
PRKAB2 [cytosol]
PRKAB2 [nucleoplasm]
Inferred To
aakb-1 [cytosol] (Caenorhabditis elegans)
alc [cytosol] (Drosophila melanogaster)
amk2 [cytosol] (Schizosaccharomyces pombe)
prkab2 [cytosol] (Xenopus tropicalis)
Prkab2 [cytosol] (Mus musculus)
Prkab2 [cytosol] (Rattus norvegicus)
GAL83 [cytosol] (Saccharomyces cerevisiae)
PRKAB2 [cytosol] (Canis familiaris)
PRKAB2 [cytosol] (Danio rerio)
PRKAB2 [cytosol] (Dictyostelium discoideum)
Cross References
RefSeq
NP_005390.1
OpenTargets
ENSG00000131791
HPA
ENSG00000131791-PRKAB2
GeneCards
O43741
Ensembl
ENSP00000254101
,
ENST00000254101
,
ENSG00000131791
PRO
O43741
Orphanet
24826
PDB
2V92
,
2Y8L
,
4CFH
,
4EAJ
,
4RER
,
2V9J
,
6B2E
,
2V8Q
,
2Y8Q
,
4EAI
,
4REW
,
2YA3
,
2F15
Interactors (22)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q08379 GOLGA2
3
GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-2167933)
p-S37-GOLGA2 [Golgi membrane]
(R-HSA-2172179)
GOLGA2 [Golgi membrane]
(R-HSA-6808764)
0.879
10
UniProt:P54646 PRKAA2
4
p-T172-PRKAA2 [cytosol]
(R-HSA-200417)
PRKAA2 [cytosol]
(R-HSA-200405)
p-T172-PRKAA2 [nucleoplasm]
(R-HSA-164171)
PRKAA2 [nucleoplasm]
(R-HSA-163682)
0.874
12
UniProt:Q9UIH9 KLF15
1
KLF15 [nucleoplasm]
(R-HSA-8878735)
0.87
9
UniProt:Q12933 TRAF2
5
K63polyUb-TRAF2 [nucleoplasm]
(R-HSA-8862194)
TRAF2 [nucleoplasm]
(R-HSA-8862199)
K63polyUb-TRAF2 [cytosol]
(R-HSA-8862193)
PolyUb-TRAF2 [cytosol]
(R-HSA-6782848)
TRAF2 [cytosol]
(R-HSA-66370)
0.83
8
UniProt:O43597 SPRY2
8
SPRY2 [cytosol]
(R-HSA-182949)
p-Y55-SPRY2 [cytosol]
(R-HSA-182950)
SPRY2 [plasma membrane]
(R-HSA-182924)
p-S112,S115-SPRY2 [cytosol]
(R-HSA-1295619)
p-Y55,Y227-SPRY2 [plasma membrane]
(R-HSA-934555)
p-S112,S121-SPRY2 [plasma membrane]
(R-HSA-934595)
p-Y55,Y227-SPRY2 [plasma membrane]
(R-HSA-1295629)
p-S111,S120-SPRY2 [cytosol]
(R-HSA-1295590)
0.666
4
UniProt:Q9GZV8 PRDM14
1
PRDM14 [nucleoplasm]
(R-HSA-1112608)
0.666
4
UniProt:Q9Y5V3 MAGED1
1
MAGED1 [cytosol]
(R-HSA-196002)
0.666
4
UniProt:Q96BA8 CREB3L1
7
CREB3L1(427-519) [Golgi membrane]
(R-HSA-8874139)
CREB3L1 [Golgi membrane]
(R-HSA-8874155)
CREB3L1(1-426) [Golgi membrane]
(R-HSA-8874153)
CREB3L1 [endoplasmic reticulum membrane]
(R-HSA-8874157)
CREB3L1(1-375) [cytosol]
(R-HSA-8874215)
CREB3L1(376-426) [Golgi membrane]
(R-HSA-8874213)
CREB3L1(1-375) [nucleoplasm]
(R-HSA-8874222)
0.666
4
UniProt:P42575 CASP2
3
CASP2(348-452) [cytosol]
(R-HSA-2976745)
CASP2(2-452) [cytosol]
(R-HSA-622412)
CASP2(170-325) [cytosol]
(R-HSA-2976746)
0.556
3
UniProt:P01185 AVP
10
AVP G23R [extracellular region]
(R-HSA-5621464)
AVP(20-28) [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869075)
AVP Y2H [extracellular region]
(R-HSA-5621449)
AVP A1T [extracellular region]
(R-HSA-5621473)
AVP V67A [extracellular region]
(R-HSA-5621446)
AVP C67* [extracellular region]
(R-HSA-5621431)
AVP P7L [extracellular region]
(R-HSA-5621460)
AVP E47del [extracellular region]
(R-HSA-5621396)
AVP(20-28) [cytosol]
(R-HSA-879509)
AVP(20-28) [extracellular region]
(R-HSA-388474)
0.556
3
UniProt:P06396 GSN
7
GSN [ficolin-1-rich granule lumen]
(R-HSA-6801465)
GSN(200-270) [extracellular region]
(R-HSA-976940)
GSN [extracellular region]
(R-HSA-6806510)
GSN [secretory granule lumen]
(R-HSA-6801486)
GSN(404-782) [cytosol]
(R-HSA-350272)
GSN(28-403) [cytosol]
(R-HSA-201618)
GSN [cytosol]
(R-HSA-350275)
0.556
3
UniProt:O75928 PIAS2
1
PIAS2 [nucleoplasm]
(R-HSA-2993787)
0.556
3
UniProt:Q14957 GRIN2C
3
p-Y-GRIN2C [plasma membrane]
(R-HSA-9612189)
GRIN2C [plasma membrane]
(R-HSA-419560)
GRIN2C [endoplasmic reticulum membrane]
(R-HSA-9609761)
0.556
3
UniProt:Q96RU7 TRIB3
3
TRIB3 [cytosol]
(R-HSA-162411)
TRIB3 [plasma membrane]
(R-HSA-199447)
TRIB3 [nucleoplasm]
(R-HSA-9635877)
0.556
3
UniProt:Q15742 NAB2
1
NAB2 [nucleoplasm]
(R-HSA-9612177)
0.556
3
UniProt:Q8N9N5 BANP
1
BANP [nucleoplasm]
(R-HSA-3221973)
0.556
3
UniProt:Q8TDS5 OXER1
1
OXER1 [plasma membrane]
(R-HSA-416425)
0.556
3
UniProt:Q01974 ROR2
2
ROR2 [clathrin-coated endocytic vesicle membrane]
(R-HSA-5140729)
ROR2 [plasma membrane]
(R-HSA-197731)
0.556
3
UniProt:P04792 HSPB1
3
p-S15,S78,S82-HSP27 [cytosol]
(R-HSA-5218697)
HSPB1 [cytosol]
(R-HSA-450563)
p-S78,S82 HSPB1 [cytosol]
(R-HSA-5687009)
0.556
3
UniProt:Q9NZH6 IL37
6
IL37(?-218) [extracellular region]
(R-HSA-9008607)
IL37(?-218) [nucleoplasm]
(R-HSA-9008702)
IL37 [extracellular region]
(R-HSA-8848334)
IL37(?-218) [cytosol]
(R-HSA-9008584)
IL37 [cytosol]
(R-HSA-9008596)
IL37(1-?) [cytosol]
(R-HSA-9008602)
0.556
5
UniProt:Q13077 TRAF1
3
TRAF1(1-163) [cytosol]
(R-HSA-5634199)
TRAF1 [cytosol]
(R-HSA-5634163)
TRAF1(164-416) [cytosol]
(R-HSA-5634204)
0.488
2
UniProt:P04637 TP53
27
TP53 [cytosol]
(R-HSA-8869337)
Unfolded TP53 [cytosol]
(R-HSA-6813797)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
SUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
Me2K-370,382-TP53 [nucleoplasm]
(R-HSA-3222242)
p-S15,S33,S46-TP53 [nucleoplasm]
(R-HSA-6805268)
p-S15,S392-TP53 [nucleoplasm]
(R-HSA-3222015)
p-T55-TP53 [nucleoplasm]
(R-HSA-6805400)
p-S15,S20,S392-TP53 [nucleoplasm]
(R-HSA-6805053)
p-S15,S20,S269,T284-TP53 [nucleoplasm]
(R-HSA-6805133)
p-S315-TP53 [nucleoplasm]
(R-HSA-6805106)
Ac-K120,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-6805656)
Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-6805631)
Ac-K382,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-5628868)
Me2-K373-TP53 [nucleoplasm]
(R-HSA-6805759)
MeK-370,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-3222226)
p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm]
(R-HSA-6804378)
Me-K382,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-3222124)
Me1-K372,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-6805719)
p-S15,S20,S46-TP53 [nucleoplasm]
(R-HSA-6798369)
p-S37-TP53 [nucleoplasm]
(R-HSA-3239022)
PolyUb,p-S15,S20-TP53 [nucleoplasm]
(R-HSA-6804446)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6793679)
PolyUb-TP53 [cytosol]
(R-HSA-6793681)
p-S15,S20-TP53 [nucleoplasm]
(R-HSA-69683)
p-S15-TP53 [nucleoplasm]
(R-HSA-69507)
TP53 [nucleoplasm]
(R-HSA-69488)
0.488
2
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