Reactome | p-T172-PRKAA2 [cytosol]

p-T172-PRKAA2 [cytosol]

Stable Identifier

R-HSA-200417

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

p-T172-AMPK alpha2

Locations in the PathwayBrowser

Expand all

Cellular responses to external stimuli (Homo sapiens)

- Macroautophagy (Homo sapiens)
  - AMPK (complex) phosphorylates ULK1 (complex) (Homo sapiens)
    - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        p-AMPK alpha [cytosol] (Homo sapiens)
        
        p-T172-PRKAA2 [cytosol] (Homo sapiens)
    - p-AMPK heterotrimer:AMP:ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        p-AMPK alpha [cytosol] (Homo sapiens)
        
        p-T172-PRKAA2 [cytosol] (Homo sapiens)
    - p-AMPK heterotrimer:AMP:p-S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        p-AMPK alpha [cytosol] (Homo sapiens)
        
        p-T172-PRKAA2 [cytosol] (Homo sapiens)
  - Thr-180 of ULK1 is phosphorylated (Homo sapiens)
    - p-AMPK heterotrimer:AMP:p-S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        p-AMPK alpha [cytosol] (Homo sapiens)
        
        p-T172-PRKAA2 [cytosol] (Homo sapiens)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        p-AMPK alpha [cytosol] (Homo sapiens)
        
        p-T172-PRKAA2 [cytosol] (Homo sapiens)
  - ULK complex translocates to the ER (Homo sapiens)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        p-AMPK alpha [cytosol] (Homo sapiens)
        
        p-T172-PRKAA2 [cytosol] (Homo sapiens)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:p-ATG13:p-RB1CC1:ATG101 [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        p-AMPK alpha [cytosol] (Homo sapiens)
        
        p-T172-PRKAA2 [cytosol] (Homo sapiens)
  - ULK1 phosphorylates AMBRA1:Beclin-1 complex (Homo sapiens)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        p-AMPK alpha [cytosol] (Homo sapiens)
        
        p-T172-PRKAA2 [cytosol] (Homo sapiens)
  - ULK1 phosphorylates ATG13 and RB1CC1 (Homo sapiens)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        p-AMPK alpha [cytosol] (Homo sapiens)
        
        p-T172-PRKAA2 [cytosol] (Homo sapiens)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:p-ATG13:p-RB1CC1:ATG101 [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        p-AMPK alpha [cytosol] (Homo sapiens)
        
        p-T172-PRKAA2 [cytosol] (Homo sapiens)
  - ULK1 phosphorylates Beclin-1 (Homo sapiens)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        p-AMPK alpha [cytosol] (Homo sapiens)
        
        p-T172-PRKAA2 [cytosol] (Homo sapiens)
  - p-AMPK:AMP binds the ULK complex (Homo sapiens)
    - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        p-AMPK alpha [cytosol] (Homo sapiens)
        
        p-T172-PRKAA2 [cytosol] (Homo sapiens)
    - p-AMPK heterotrimer:AMP:ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        p-AMPK alpha [cytosol] (Homo sapiens)
        
        p-T172-PRKAA2 [cytosol] (Homo sapiens)
  - p-AMPK:AMP phosphorylates Raptor in the mTORC1 complex (Homo sapiens)
    - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        p-AMPK alpha [cytosol] (Homo sapiens)
        
        p-T172-PRKAA2 [cytosol] (Homo sapiens)

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Metabolic Genes (Homo sapiens)
        
        SESN1,2,3 bind AMPK (Homo sapiens)
        
        SESN1,2,3:p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        p-AMPK alpha [cytosol] (Homo sapiens)
        
        p-T172-PRKAA2 [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        p-AMPK alpha [cytosol] (Homo sapiens)
        
        p-T172-PRKAA2 [cytosol] (Homo sapiens)
        
        p-AMPK phosphorylates TSC1:TSC2 (Homo sapiens)
        
        p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        p-AMPK alpha [cytosol] (Homo sapiens)
        
        p-T172-PRKAA2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P54646 PRKAA2

Gene Names

PRKAA2, AMPK, AMPK2

Chain

chain:1-552

Reference Genes

BioGPS Gene:5563 PRKAA2

COSMIC (genes):PRKAA2 PRKAA2

CTD Gene:5563 PRKAA2

dbSNP Gene:5563 PRKAA2

ENSEMBL:ENSG00000162409 PRKAA2

ENSEMBL_homo_sapiens_GENE:ENSG00000162409 PRKAA2

HGNC:9377 PRKAA2

KEGG Gene (Homo sapiens):5563 PRKAA2

Monarch:5563 PRKAA2

NCBI Gene:5563 PRKAA2

OMIM:600497 PRKAA2

UCSC:P54646 PRKAA2

Reference Transcript

RefSeq:NM_006252.3 PRKAA2

Other Identifiers

0004730088

04150+2.7.11.1

04151+2.7.11.1

04714+2.7.11.1

04926+2.7.11.1

05163+2.7.11.1

05165+2.7.11.1

05170+2.7.11.1

11729364_at

11729365_at

11729366_at

11729367_at

16665182

186_at

207709_at

227892_at

2337719

2337720

2337721

2337725

2337728

2337729

2337730

2337732

2337733

2337734

2337735

2337736

2337737

2337738

2337739

2337741

2337743

2337744

2337745

238441_at

238489_at

240349_at

2H6D

2LTU

2YZA

3AQV

41929_at

44540

4CFE

4CFF

4ZHX

54326_at

5563

57820_r_at

5EZV

5ISO

6B1U

6B2E

6BX6

7901720

82810_at

90088_at

A0A087WXX9

A_23_P60811

A_32_P94160

AAA64745

AAH69680

AAH69740

AAH69823

AL035705

BC069680

BC069740

BC069823

CCDS605

ENSG00000162409

ENSP00000360290

ENST00000371244

ENST00000371244.8

EntrezGene:5563

g5453965_3p_at

GE58883

GE813527

GO:0000166

GO:0003674

GO:0003682

GO:0004672

GO:0004674

GO:0004679

GO:0004712

GO:0005515

GO:0005524

GO:0005575

GO:0005634

GO:0005654

GO:0005737

GO:0005794

GO:0005829

GO:0006325

GO:0006464

GO:0006468

GO:0006629

GO:0006631

GO:0006633

GO:0006694

GO:0006695

GO:0006810

GO:0006853

GO:0006914

GO:0006950

GO:0007050

GO:0007165

GO:0008150

GO:0008202

GO:0008203

GO:0008610

GO:0009056

GO:0009058

GO:0010468

GO:0010494

GO:0010508

GO:0010629

GO:0014850

GO:0016055

GO:0016126

GO:0016236

GO:0016239

GO:0016241

GO:0016301

GO:0016310

GO:0016607

GO:0016740

GO:0030424

GO:0030425

GO:0031588

GO:0031669

GO:0032007

GO:0032991

GO:0034599

GO:0035174

GO:0035404

GO:0035556

GO:0035690

GO:0042149

GO:0042304

GO:0042592

GO:0042593

GO:0042752

GO:0043025

GO:0043066

GO:0043167

GO:0043226

GO:0044281

GO:0045821

GO:0046872

GO:0047322

GO:0048511

GO:0050405

GO:0055085

GO:0055089

GO:0062028

GO:0070507

GO:0071277

GO:0071333

GO:0071380

GO:0097009

GO:1901796

GO:1903829

GO:1904428

GO:2000758

HGNC:9377

HPA044540

Hs.127301.0.A1_3p_at

Hs.139293.0.S1_3p_at

Hs.145568.0.A1_3p_at

Hs.86379.0.A1_3p_at

Hs.86379.0.A1_3p_x_at

ILMN_1668778

IPR000719

IPR008271

IPR011009

IPR017441

IPR028375

IPR032270

IPR039148

MIM:600497

NM_006252

NP_006243

PF00069

PF16579

PH_hs_0020627

PH_hs_0023278

PRKAA2

PRKAA2-201

SM00220

TC01000685.hg

TC01004414.hg

U06454

U06454_at

UPI00001250A9

XM_017001692

XM_017001693

XM_017001694

XP_016857181

XP_016857182

XP_016857183

XR_001737290

Participant Of

hasComponent

hasMember

p-AMPK alpha [cytosol]

Other forms of this molecule

PRKAA2 [cytosol]

p-T172-PRKAA2 [nucleoplasm]

PRKAA2 [nucleoplasm]

Inferred To

phospho-p-T172-PRKAA2 [cytosol] (Bos taurus)

phospho-p-T172-PRKAA2 [cytosol] (Caenorhabditis elegans)

phospho-p-T172-PRKAA2 [cytosol] (Canis familiaris)

phospho-p-T172-PRKAA2 [cytosol] (Danio rerio)

phospho-p-T172-PRKAA2 [cytosol] (Dictyostelium discoideum)

phospho-p-T172-PRKAA2 [cytosol] (Drosophila melanogaster)

phospho-p-T172-PRKAA2 [cytosol] (Gallus gallus)

phospho-p-T172-PRKAA2 [cytosol] (Mus musculus)

phospho-p-T172-PRKAA2 [cytosol] (Rattus norvegicus)

phospho-p-T172-PRKAA2 [cytosol] (Saccharomyces cerevisiae)

phospho-p-T172-PRKAA2 [cytosol] (Schizosaccharomyces pombe)

phospho-p-T172-PRKAA2 [cytosol] (Xenopus tropicalis)

Modified Residues

Name

O-phospho-L-threonine at 172

Coordinate

172

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

NP_006243.2

OpenTargets

ENSG00000162409

GeneCards

P54646

ZINC target

P54646

PRO

P54646

HMDB Protein

HMDBP01902

PDB

4CFF, 4CFE, 6BX6, 6B2E, 3AQV, 4ZHX, 6B1U, 2YZA, 2LTU, 5EZV, 5ISO, 2H6D

Interactors (112)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O43741 PRKAB2	3	PRKAB2 [nucleoplasm] (R-HSA-164096) PRKAB2 [cytosol] (R-HSA-200413) PRKAB2 [cytosol] (R-HSA-200411)	0.821	12
UniProt:P54619 PRKAG1	2	PRKAG1 [nucleoplasm] (R-HSA-2151202) PRKAG1 [cytosol] (R-HSA-380946)	0.77	9
UniProt:Q9BVG8 KIFC3			0.666	4
UniProt:Q9Y478 PRKAB1	2	PRKAB1 [cytosol] (R-HSA-380968) PRKAB1 [nucleoplasm] (R-HSA-2151199)	0.635	3
UniProt:Q04864-2 REL			0.621	3
UniProt:Q5JR59-3 MTUS2			0.621	3
UniProt:O75385 ULK1	7	ULK1 [mitochondrial outer membrane] (R-HSA-8948145) ULK1 [cytosol] (R-HSA-1632847) p-T180,S317,S467,S556,S638,T575-ULK1 [endoplasmic reticulum membrane] (R-HSA-8948047) p-S758-ULK1 [cytosol] (R-HSA-5672131) p-T180,S317,S467,S556,S638,T575-ULK1 [cytosol] (R-HSA-5675858) p-S317,467,556,638,T575-ULK1 [cytosol] (R-HSA-5673747) ULK1 [recycling endosome] (R-HSA-8854761)	0.589	2
UniProt:Q13131 PRKAA1	3	PRKAA1 [cytosol] (R-HSA-380935) p-T183-PRKAA1 [nucleoplasm] (R-HSA-2151206) p-T183-PRKAA1 [cytosol] (R-HSA-380964)	0.564	3
UniProt:Q6NT76 HMBX1			0.556	3
UniProt:Q5T7B8-2 KIF24			0.556	3
IntAct:EBI-10171679 386682			0.556	3
UniProt:Q6FG41 Q6FG41			0.556	3
UniProt:Q08117 AES	1	AES [nucleoplasm] (R-HSA-4648963)	0.556	3
UniProt:Q93062 RBPMS			0.556	3
UniProt:Q96BR9 ZBT8A			0.556	3
UniProt:Q15323 KRT31	1	KRT31 [cytosol] (R-HSA-6809616)	0.556	3
UniProt:Q9NPC3 CIP1			0.556	3
UniProt:Q86Y26 NUTM1			0.556	3
UniProt:Q9Y3Q8 T22D4			0.556	3
UniProt:Q8N1B4 VPS52	1	VPS52 [trans-Golgi network membrane] (R-HSA-6811029)	0.556	3
UniProt:Q15654 TRIP6			0.556	3
UniProt:Q92624 APBP2			0.556	3
UniProt:Q719H9 KCTD1	1	KCTD1 [nucleoplasm] (R-HSA-8864339)	0.556	3
UniProt:Q9NYB9 ABI2	2	ABI2 [cytosol] (R-HSA-1671647) p-4S-ABI2 [cytosol] (R-HSA-2029003)	0.556	3
UniProt:P08151 GLI1	9	GLI1 [ciliary base] (R-HSA-5610357) GLI1 [ciliary tip] (R-HSA-5610360) p-GLI1 [nucleoplasm] (R-HSA-5635042) 2p-GLI1 [nucleoplasm] (R-HSA-5635057) p-GLI1 [ciliary tip] (R-HSA-5635040) GLI1 [cytosol] (R-HSA-445457) pS-GLI1 [ciliary base] (R-HSA-5610497) ub-pS-GLI1 [ciliary base] (R-HSA-5610514) ub-GLI1 [cytosol] (R-HSA-5635833)	0.556	3
UniProt:Q15233-2 NONO			0.556	3
UniProt:Q96JM7 LMBL3			0.556	3
UniProt:Q8NF99 ZN397			0.556	3
UniProt:Q7Z6G3-2 NECAB2			0.556	3
UniProt:Q8IX15-3 HOMEZ			0.556	3
UniProt:Q13155 AIMP2	1	AIMP2 [cytosol] (R-HSA-379576)	0.556	3
UniProt:Q8HWS3 RFX6	1	RFX6 [nucleoplasm] (R-HSA-8931801)	0.556	3
UniProt:Q8N6Y0 USBP1			0.556	3
UniProt:P15884 TCF4	1	TCF4 [nucleoplasm] (R-HSA-445672)	0.556	3
UniProt:Q7Z3S9 NT2NA			0.556	3
UniProt:Q8IZE3-2 SCYL3			0.488	2
IntAct:EBI-19145652 YPEL3-51			0.488	2
UniProt:Q9UBR4-2 LHX3			0.488	2
UniProt:Q9ULX6 AKP8L			0.488	2
UniProt:Q9P1Z2 CACO1			0.488	2
UniProt:Q13137 CACO2			0.488	2
UniProt:Q7Z5V6-2 PPP1R32			0.488	2
UniProt:Q53EP0-3 FNDC3B			0.488	2
IntAct:EBI-11749135 KRTAP13			0.488	2
UniProt:Q9Y2J4 AMOTL2	1	AMOTL2 [cytosol] (R-HSA-2028606)	0.488	2
UniProt:Q9UK41-2 VPS28			0.488	2
UniProt:Q8IZP0-5 ABI1			0.488	2
UniProt:A8MQ03 CRTP1			0.488	2
UniProt:Q9NQX0 PRDM6			0.488	2
UniProt:P41219 PERI			0.488	2
UniProt:Q86T90 K1328			0.488	2
IntAct:EBI-11957986 HOMEZ			0.488	2
UniProt:O75791 GRAP2	1	GRAP2 [cytosol] (R-HSA-202367)	0.488	2
UniProt:Q5T686 AVPI1			0.488	2
UniProt:Q5JUK2 SOLH1			0.488	2
UniProt:Q9NQM4 PIHD3			0.488	2
IntAct:EBI-11522976 CCDC33			0.488	2
UniProt:O75638-2 CTAG2			0.488	2
UniProt:Q96B67 ARRD3			0.488	2
UniProt:Q9NYG5-2 ANAPC11			0.488	2
UniProt:Q9Y6C2-2 EMILIN1			0.488	2
UniProt:Q9UKT9 IKZF3			0.488	2
UniProt:O95208-2 EPN2			0.488	2
UniProt:P32321 DCTD	1	DCTD [cytosol] (R-HSA-73592)	0.488	2
UniProt:P0C7W6 CC172			0.488	2
UniProt:Q6ZR03 YU004			0.488	2
UniProt:Q7L273 KCTD9			0.488	2
UniProt:Q9BRK4 LZTS2			0.488	2
UniProt:Q13422-7 IKZF1			0.488	2
UniProt:Q96L93-6 KIF16B			0.488	2
UniProt:Q92997 DVL3	4	DVL3 [cytosol] (R-HSA-201678) ub-DVL3 [cytosol] (R-HSA-4652688) p-DVL3 [cytosol] (R-HSA-201680) pp-DVL3 [cytosol] (R-HSA-3772400)	0.488	2
UniProt:Q9H9H4 VPS37B	1	VPS37B [endosome membrane] (R-HSA-184293)	0.488	2
UniProt:Q9NYB9-2 ABI2			0.488	2
UniProt:P12524-2 P125242			0.488	2
UniProt:Q13064 MKRN3			0.488	2
UniProt:P31321 PRKAR1B	2	PRKAR1B [cytosol] (R-HSA-57838) PRKAR1B [ciliary base] (R-HSA-5610409)	0.488	2
UniProt:Q02446 SP4			0.488	2
UniProt:Q6PF18 MORN3			0.488	2
UniProt:Q9H0C1 ZMY12			0.488	2
UniProt:Q15477 SKIV2L	1	SKIV2L [cytosol] (R-HSA-391294)	0.488	2
UniProt:Q3MJ62 ZSC23			0.488	2
UniProt:P08779 KRT16	1	KRT16 [cytosol] (R-HSA-201581)	0.488	2
UniProt:Q9UDV6 ZNF212	1	ZNF212 [nucleoplasm] (R-HSA-1027348)	0.488	2
UniProt:Q8N684-3 CPSF7			0.488	2
UniProt:Q96CG3 TIFA			0.488	2
UniProt:Q495M9 USH1G			0.488	2
UniProt:P80188 LCN2	2	LCN2 [extracellular region] (R-HSA-5215934) LCN2 [specific granule lumen] (R-HSA-6799614)	0.488	2
UniProt:O75420 GGYF1			0.488	2
UniProt:Q9H6Q3 SLAP2			0.488	2
IntAct:EBI-19130346 WASHC1			0.488	2
UniProt:Q494U1-3 PLEKHN1			0.488	2
UniProt:Q15645 PCH2			0.488	2
UniProt:Q96JM7-2 L3MBTL3			0.488	2
UniProt:Q01850 CDR2			0.488	2
UniProt:P56545-3 CTBP2			0.488	2
UniProt:Q96F24 NRBF2			0.488	2
UniProt:Q08379 GOLGA2	3	GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.488	2
UniProt:A1L4K1 FSD2			0.488	2
UniProt:P50570 DNM2	5	DNM2 [endocytic vesicle membrane] (R-HSA-2029000) DNM2 [plasma membrane] (R-HSA-2984201) DNM2 [cytosol] (R-HSA-2213180) DNM2 [lysosomal membrane] (R-HSA-2980840) DNM2 [Golgi membrane] (R-HSA-2980842)	0.488	2
UniProt:P60411 KRTAP10-9	1	KRTAP10-9 [cytosol] (R-HSA-6810277)	0.488	2
UniProt:Q63ZY3 KANK2			0.488	2
UniProt:A2BDD9 A2BDD9			0.488	2
UniProt:Q6ZMT1 STAC2			0.488	2
UniProt:Q00587-2 CDC42EP1			0.488	2
UniProt:O43609 SPRY1	3	SPRY1 [plasma membrane] (R-HSA-182944) SPRY1 [cytosol] (R-HSA-182908) p-Y53-SPRY1 [cytosol] (R-HSA-182933)	0.488	2
UniProt:Q9NYA3 GOG6A			0.488	2
UniProt:Q9Y6N9-4 USH1C			0.488	2
UniProt:Q86YV0 RASAL3	1	RASAL3 [cytosol] (R-HSA-5658226)	0.488	2
UniProt:Q15742 NAB2			0.488	2
UniProt:Q9UJW9 SRTD3			0.488	2
UniProt:O14627 CDX4			0.488	2
UniProt:O00308 WWP2	1	WWP2 [cytosol] (R-HSA-6807279)	0.488	2