Reactome | p-T172-PRKAA2 [cytosol]

p-T172-PRKAA2 [cytosol]

Stable Identifier

R-HSA-200417

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

p-T172-AMPK alpha2

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Locations in the PathwayBrowser

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Autophagy (Homo sapiens)

- Macroautophagy (Homo sapiens)
  - AMPK (complex) phosphorylates ULK1 (complex) (Homo sapiens)
    - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        p-AMPK alpha [cytosol] (Homo sapiens)
        
        p-T172-PRKAA2 [cytosol] (Homo sapiens)
    - p-AMPK heterotrimer:AMP:ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        p-AMPK alpha [cytosol] (Homo sapiens)
        
        p-T172-PRKAA2 [cytosol] (Homo sapiens)
    - p-AMPK heterotrimer:AMP:p-S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        p-AMPK alpha [cytosol] (Homo sapiens)
        
        p-T172-PRKAA2 [cytosol] (Homo sapiens)
  - Selective autophagy (Homo sapiens)
    - Lipophagy (Homo sapiens)
      - PRKAA2 phosphorylates PLINs (Homo sapiens)
        
        AMPK-alpha2:AMPK-beta:AMPK-gamma:AMP [cytosol] (Homo sapiens)
        
        p-T172-PRKAA2 [cytosol] (Homo sapiens)
        
        p-T172-PRKAA2 [cytosol] (Homo sapiens)
  - Thr-180 of ULK1 is phosphorylated (Homo sapiens)
    - p-AMPK heterotrimer:AMP:p-S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        p-AMPK alpha [cytosol] (Homo sapiens)
        
        p-T172-PRKAA2 [cytosol] (Homo sapiens)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        p-AMPK alpha [cytosol] (Homo sapiens)
        
        p-T172-PRKAA2 [cytosol] (Homo sapiens)
  - ULK complex translocates to the ER (Homo sapiens)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        p-AMPK alpha [cytosol] (Homo sapiens)
        
        p-T172-PRKAA2 [cytosol] (Homo sapiens)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:p-ATG13:p-RB1CC1:ATG101 [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        p-AMPK alpha [cytosol] (Homo sapiens)
        
        p-T172-PRKAA2 [cytosol] (Homo sapiens)
  - ULK1 phosphorylates AMBRA1:BECN1 complex (Homo sapiens)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        p-AMPK alpha [cytosol] (Homo sapiens)
        
        p-T172-PRKAA2 [cytosol] (Homo sapiens)
  - ULK1 phosphorylates ATG13 and RB1CC1 (Homo sapiens)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        p-AMPK alpha [cytosol] (Homo sapiens)
        
        p-T172-PRKAA2 [cytosol] (Homo sapiens)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:p-ATG13:p-RB1CC1:ATG101 [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        p-AMPK alpha [cytosol] (Homo sapiens)
        
        p-T172-PRKAA2 [cytosol] (Homo sapiens)
  - ULK1 phosphorylates Beclin-1 (Homo sapiens)
    - p-AMPK heterotrimer:AMP:p-T180,S317,467,556,638,T575-ULK1:ATG13:RB1CC1:ATG101 [endoplasmic reticulum membrane] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        p-AMPK alpha [cytosol] (Homo sapiens)
        
        p-T172-PRKAA2 [cytosol] (Homo sapiens)
  - p-AMPK:AMP binds the ULK complex (Homo sapiens)
    - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        p-AMPK alpha [cytosol] (Homo sapiens)
        
        p-T172-PRKAA2 [cytosol] (Homo sapiens)
    - p-AMPK heterotrimer:AMP:ULK1:ATG13:RB1CC1:ATG101 [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        p-AMPK alpha [cytosol] (Homo sapiens)
        
        p-T172-PRKAA2 [cytosol] (Homo sapiens)
  - p-AMPK:AMP phosphorylates Raptor in the MTORC1 complex (Homo sapiens)
    - p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
      - p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        p-AMPK alpha [cytosol] (Homo sapiens)
        
        p-T172-PRKAA2 [cytosol] (Homo sapiens)

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Metabolic Genes (Homo sapiens)
        
        SESN1,2,3 bind AMPK (Homo sapiens)
        
        SESN1,2,3:p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        p-AMPK alpha [cytosol] (Homo sapiens)
        
        p-T172-PRKAA2 [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        p-AMPK alpha [cytosol] (Homo sapiens)
        
        p-T172-PRKAA2 [cytosol] (Homo sapiens)
        
        p-AMPK phosphorylates TSC1:TSC2 (Homo sapiens)
        
        p-AMPK heterotrimer:AMP [cytosol] (Homo sapiens)
        
        p-AMPK heterotrimer [cytosol] (Homo sapiens)
        
        p-AMPK alpha [cytosol] (Homo sapiens)
        
        p-T172-PRKAA2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P54646 PRKAA2

Gene Names

PRKAA2, AMPK, AMPK2

Chain

chain:1-552

Reference Genes

BioGPS Gene:5563 PRKAA2

COSMIC (genes):PRKAA2 PRKAA2

CTD Gene:5563 PRKAA2

dbSNP Gene:5563 PRKAA2

ENSEMBL:ENSG00000162409 PRKAA2

HGNC:9377 PRKAA2

KEGG Gene (Homo sapiens):5563 PRKAA2

Monarch:5563 PRKAA2

NCBI Gene:5563 PRKAA2

OMIM:600497 PRKAA2

UCSC:P54646 PRKAA2

Reference Transcript

RefSeq:NM_006252.3 PRKAA2

Other Identifiers

0004730088

11729364_at

11729365_at

11729366_at

11729367_at

16665182

186_at

207709_at

227892_at

2337719

2337720

2337721

2337725

2337728

2337729

2337730

2337732

2337733

2337734

2337735

2337736

2337737

2337738

2337739

2337741

2337743

2337744

2337745

2337747

238441_at

238489_at

240349_at

41929_at

54326_at

5563

57820_r_at

7901720

82810_at

90088_at

A_23_P60811

A_32_P94160

GE58883

GE813527

GO:0000166

GO:0003674

GO:0003682

GO:0004672

GO:0004674

GO:0004679

GO:0004712

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005794

GO:0005829

GO:0005975

GO:0006091

GO:0006325

GO:0006464

GO:0006468

GO:0006629

GO:0006631

GO:0006633

GO:0006694

GO:0006695

GO:0006810

GO:0006853

GO:0006914

GO:0006950

GO:0007010

GO:0007049

GO:0007050

GO:0007165

GO:0007267

GO:0008150

GO:0008202

GO:0008203

GO:0008219

GO:0008610

GO:0009056

GO:0009058

GO:0010468

GO:0010494

GO:0010508

GO:0010629

GO:0014850

GO:0016055

GO:0016126

GO:0016236

GO:0016239

GO:0016241

GO:0016301

GO:0016310

GO:0016607

GO:0016740

GO:0022607

GO:0030424

GO:0030425

GO:0031669

GO:0032007

GO:0034599

GO:0034641

GO:0035174

GO:0035404

GO:0035556

GO:0035690

GO:0042149

GO:0042304

GO:0042592

GO:0042593

GO:0042752

GO:0043025

GO:0043066

GO:0043167

GO:0043226

GO:0044281

GO:0045821

GO:0046872

GO:0047322

GO:0048511

GO:0050405

GO:0051276

GO:0055085

GO:0055089

GO:0062028

GO:0070507

GO:0071277

GO:0071333

GO:0071380

GO:0097009

GO:1901796

GO:1903829

GO:1904428

GO:2000758

Hs.127301.0.A1_3p_at

Hs.139293.0.S1_3p_at

Hs.145568.0.A1_3p_at

Hs.86379.0.A1_3p_at

Hs.86379.0.A1_3p_x_at

ILMN_1668778

PH_hs_0020627

PH_hs_0023278

TC01000685.hg

TC01004414.hg

U06454_at

g5453965_3p_at

Participant Of

hasComponent

hasMember

p-AMPK alpha [cytosol]

Other forms of this molecule

PRKAA2 [cytosol]

p-T172-PRKAA2 [nucleoplasm]

PRKAA2 [nucleoplasm]

Inferred To

phospho-FRK1 [cytosol] (Saccharomyces cerevisiae)

Homologues of p-T172-PRKAA2 [cytosol] (Caenorhabditis elegans)

Homologues of p-T172-PRKAA2 [cytosol] (Saccharomyces cerevisiae)

Homologues of p-T172-PRKAA2 [cytosol] (Schizosaccharomyces pombe)

phospho-PRKAA2 [cytosol] (Bos taurus)

phospho-PRKAA2 [cytosol] (Canis familiaris)

phospho-ssp2 [cytosol] (Schizosaccharomyces pombe)

phospho-ppk27 [cytosol] (Schizosaccharomyces pombe)

phospho-Prkaa2 [cytosol] (Mus musculus)

phospho-Prkaa2 [cytosol] (Rattus norvegicus)

phospho-SNF1 [cytosol] (Saccharomyces cerevisiae)

phospho-p-T172-PRKAA2 [cytosol] (Gallus gallus)

phospho-p-T172-PRKAA2 [cytosol] (Saccharomyces cerevisiae)

phospho-ppk16 [cytosol] (Schizosaccharomyces pombe)

phospho-PRR1 [cytosol] (Saccharomyces cerevisiae)

phospho-ppk9 [cytosol] (Schizosaccharomyces pombe)

phospho-AMPKalpha [cytosol] (Drosophila melanogaster)

phospho-snfA [cytosol] (Dictyostelium discoideum)

phospho-aak-1 [cytosol] (Caenorhabditis elegans)

phospho-KIN4 [cytosol] (Saccharomyces cerevisiae)

phospho-prkaa2 [cytosol] (Danio rerio)

phospho-prkaa2 [cytosol] (Xenopus tropicalis)

phospho-aak-2 [cytosol] (Caenorhabditis elegans)

phospho-ppk1 [cytosol] (Schizosaccharomyces pombe)

Modified Residues

Name

O-phospho-L-threonine at 172

Coordinate

172

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

NP_006243.2

OpenTargets

ENSG00000162409

HPA

ENSG00000162409-PRKAA2

GeneCards

P54646

Ensembl

ENSG00000162409, ENSP00000360290, ENST00000371244

ZINC target

P54646

PRO

P54646

HMDB Protein

HMDBP01902

PDB

2H6D, 6BX6, 6B2E, 4ZHX, 3AQV, 2LTU, 6B1U, 2YZA, 4CFF, 4CFE, 5ISO, 5EZV

Interactors (111)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P54619 PRKAG1	2	PRKAG1 [cytosol] (R-HSA-380946) PRKAG1 [nucleoplasm] (R-HSA-2151202)	0.874	12
UniProt:O43741 PRKAB2	3	PRKAB2 [nucleoplasm] (R-HSA-164096) PRKAB2 [cytosol] (R-HSA-200413) PRKAB2 [cytosol] (R-HSA-200411)	0.874	12
UniProt:Q9Y478 PRKAB1	2	PRKAB1 [cytosol] (R-HSA-380968) PRKAB1 [nucleoplasm] (R-HSA-2151199)	0.75	7
UniProt:Q5JR59-3 MTUS2			0.666	4
UniProt:Q9NPC3 CIP1			0.666	4
UniProt:Q9NYB9 ABI2	2	ABI2 [cytosol] (R-HSA-1671647) p-4S-ABI2 [cytosol] (R-HSA-2029003)	0.666	5
UniProt:Q9BVG8 KIFC3			0.666	4
UniProt:Q04864-2 REL			0.666	4
UniProt:O75385 ULK1	7	ULK1 [cytosol] (R-HSA-1632847) ULK1 [recycling endosome] (R-HSA-8854761) ULK1 [mitochondrial outer membrane] (R-HSA-8948145) p-T180,S317,S467,S556,S638,T575-ULK1 [endoplasmic reticulum membrane] (R-HSA-8948047) p-T180,S317,S467,S556,S638,T575-ULK1 [cytosol] (R-HSA-5675858) p-S317,467,556,638,T575-ULK1 [cytosol] (R-HSA-5673747) p-S758-ULK1 [cytosol] (R-HSA-5672131)	0.589	2
UniProt:Q15831 STK11	2	STK11 [nucleoplasm] (R-HSA-164119) STK11 [cytosol] (R-HSA-380954)	0.589	3
UniProt:Q9P246 STIM2			0.564	2
UniProt:Q13131 PRKAA1	3	PRKAA1 [cytosol] (R-HSA-380935) p-T183-PRKAA1 [cytosol] (R-HSA-380964) p-T183-PRKAA1 [nucleoplasm] (R-HSA-2151206)	0.564	3
UniProt:Q6NT76 HMBX1			0.556	3
UniProt:Q9Y3C5 RNF11			0.556	3
UniProt:Q5T7B8-2 KIF24			0.556	3
UniProt:Q9Y605 MOFA1			0.556	3
UniProt:Q9ULX6 AKP8L			0.556	3
UniProt:Q9P1Z2 CACO1			0.556	3
UniProt:Q13137 CACO2			0.556	3
UniProt:Q7Z5V6-2 PPP1R32			0.556	3
IntAct:EBI-10171679 386682			0.556	3
UniProt:Q6FG41 Q6FG41			0.556	3
UniProt:Q08117 TLE5	1	AES [nucleoplasm] (R-HSA-4648963)	0.556	3
UniProt:Q93062 RBPMS			0.556	3
UniProt:Q53EP0-3 FNDC3B			0.556	3
UniProt:Q9Y2J4 AMOTL2	1	AMOTL2 [cytosol] (R-HSA-2028606)	0.556	3
UniProt:Q96BR9 ZBT8A			0.556	3
UniProt:Q9UK41-2 VPS28			0.556	3
UniProt:Q08117-2 TLE5			0.556	3
UniProt:Q8IZP0-5 ABI1			0.556	3
UniProt:Q15323 KRT31	1	KRT31 [cytosol] (R-HSA-6809616)	0.556	3
UniProt:A8MQ03 CRTP1			0.556	3
UniProt:Q9NQX0 PRDM6			0.556	3
UniProt:P41219 PERI			0.556	3
UniProt:Q86T90 K1328			0.556	3
UniProt:O75791 GRAP2	1	GRAP2 [cytosol] (R-HSA-202367)	0.556	3
UniProt:Q5T686 AVPI1			0.556	3
IntAct:EBI-22384931 CCSB ORF ID			0.556	3
UniProt:Q5JUK2 SOLH1			0.556	3
UniProt:Q9NQM4 DAAF6			0.556	3
UniProt:Q86Y26 NUTM1			0.556	3
IntAct:EBI-22432104 CCSB ORF ID			0.556	3
UniProt:Q9Y3Q8 T22D4			0.556	3
UniProt:Q96B67 ARRD3			0.556	3
UniProt:O75638-2 CTAG2			0.556	3
UniProt:Q8N1B4 VPS52	1	VPS52 [trans-Golgi network membrane] (R-HSA-6811029)	0.556	3
UniProt:Q15654 TRIP6			0.556	3
UniProt:Q9NYG5-2 ANAPC11			0.556	3
UniProt:Q92624 APBP2			0.556	3
UniProt:Q9Y6C2-2 EMILIN1			0.556	3
UniProt:Q9UKT9 IKZF3			0.556	3
UniProt:O95208-2 EPN2			0.556	3
UniProt:P0C7W6 CC172			0.556	3
UniProt:O00308 WWP2	1	WWP2 [cytosol] (R-HSA-6807279)	0.556	3
UniProt:Q7L273 KCTD9			0.556	3
UniProt:Q9BRK4 LZTS2			0.556	3
UniProt:Q13422-7 IKZF1			0.556	3
UniProt:Q92997 DVL3	4	p-DVL3 [cytosol] (R-HSA-201680) pp-DVL3 [cytosol] (R-HSA-3772400) DVL3 [cytosol] (R-HSA-201678) ub-DVL3 [cytosol] (R-HSA-4652688)	0.556	3
UniProt:Q96L93-6 KIF16B			0.556	3
UniProt:Q9NYB9-2 ABI2			0.556	3
UniProt:Q9H9H4 VPS37B	1	VPS37B [endosome membrane] (R-HSA-184293)	0.556	3
UniProt:P12524-2 P125242			0.556	3
UniProt:Q13064 MKRN3			0.556	3
UniProt:P31321 PRKAR1B	2	PRKAR1B [ciliary base] (R-HSA-5610409) PRKAR1B [cytosol] (R-HSA-57838)	0.556	3
UniProt:Q6PF18 MORN3			0.556	3
UniProt:Q719H9 KCTD1	1	KCTD1 [nucleoplasm] (R-HSA-8864339)	0.556	3
UniProt:Q9H0C1 ZMY12			0.556	3
UniProt:Q15477 SKIV2L	1	SKIV2L [cytosol] (R-HSA-391294)	0.556	3
UniProt:Q3MJ62 ZSC23			0.556	3
UniProt:P08779 KRT16	1	KRT16 [cytosol] (R-HSA-201581)	0.556	3
UniProt:Q9UDV6 ZNF212	1	ZNF212 [nucleoplasm] (R-HSA-1027348)	0.556	3
UniProt:Q15233-2 NONO			0.556	3
UniProt:Q8N684-3 CPSF7			0.556	3
UniProt:Q96JM7 LMBL3			0.556	3
UniProt:Q495M9 USH1G			0.556	3
UniProt:Q96CG3 TIFA	2	p-T9-TIFA [cytosol] (R-HSA-9645512) TIFA [cytosol] (R-HSA-451582)	0.556	3
UniProt:Q8NF99 ZN397			0.556	3
UniProt:P80188 LCN2	2	LCN2 [extracellular region] (R-HSA-5215934) LCN2 [specific granule lumen] (R-HSA-6799614)	0.556	3
UniProt:O75420 GGYF1			0.556	3
UniProt:Q9H6Q3 SLA2	1	SLA2 [cytosol] (R-HSA-9706161)	0.556	3
IntAct:EBI-16439879 CCSB ORF ID			0.556	3
IntAct:EBI-16436244 CCSB ORF ID			0.556	3
UniProt:Q494U1-3 PLEKHN1			0.556	3
UniProt:Q15645 PCH2			0.556	3
IntAct:EBI-22310722 CCSB ORF ID			0.556	3
UniProt:Q96JM7-2 L3MBTL3			0.556	3
UniProt:Q7Z6G3-2 NECAB2			0.556	3
UniProt:Q8IX15-3 HOMEZ			0.556	3
UniProt:Q01850 CDR2			0.556	3
UniProt:Q96F24 NRBF2			0.556	3
UniProt:Q08379 GOLGA2	3	GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.556	3
UniProt:P50570 DNM2	5	DNM2 [plasma membrane] (R-HSA-2984201) DNM2 [Golgi membrane] (R-HSA-2980842) DNM2 [cytosol] (R-HSA-2213180) DNM2 [endocytic vesicle membrane] (R-HSA-2029000) DNM2 [lysosomal membrane] (R-HSA-2980840)	0.556	3
UniProt:Q13155 AIMP2	1	AIMP2 [cytosol] (R-HSA-379576)	0.556	3
UniProt:Q8HWS3 RFX6	1	RFX6 [nucleoplasm] (R-HSA-8931801)	0.556	3
UniProt:Q8N6Y0 USBP1			0.556	3
UniProt:P15884 TCF4	1	TCF4 [nucleoplasm] (R-HSA-445672)	0.556	3
UniProt:P60411 KRTAP10-9	1	KRTAP10-9 [cytosol] (R-HSA-6810277)	0.556	3
UniProt:Q7Z3S9 NT2NA			0.556	3
UniProt:A2BDD9 A2BDD9			0.556	3
UniProt:Q6ZMT1 STAC2			0.556	3
UniProt:Q00587-2 CDC42EP1			0.556	3
UniProt:O43609 SPRY1	3	p-Y53-SPRY1 [cytosol] (R-HSA-182933) SPRY1 [cytosol] (R-HSA-182908) SPRY1 [plasma membrane] (R-HSA-182944)	0.556	3
UniProt:Q9NYA3 GOG6A			0.556	3
UniProt:P28799 GRN	2	GRN [extracellular region] (R-HSA-6806217) GRN [azurophil granule lumen] (R-HSA-6799168)	0.556	3
UniProt:Q9Y6N9-4 USH1C			0.556	3
UniProt:Q86YV0 RASAL3	1	RASAL3 [cytosol] (R-HSA-5658226)	0.556	3
UniProt:Q9UJW9 SRTD3			0.556	3
UniProt:O14627 CDX4			0.556	3
UniProt:Q15742 NAB2	1	NAB2 [nucleoplasm] (R-HSA-9612177)	0.556	3
UniProt:O76024 WFS1	3	p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:P08151 GLI1	9	pS-GLI1 [ciliary base] (R-HSA-5610497) ub-pS-GLI1 [ciliary base] (R-HSA-5610514) ub-GLI1 [cytosol] (R-HSA-5635833) GLI1 [cytosol] (R-HSA-445457) GLI1 [ciliary tip] (R-HSA-5610360) GLI1 [ciliary base] (R-HSA-5610357) p-GLI1 [nucleoplasm] (R-HSA-5635042) 2p-GLI1 [nucleoplasm] (R-HSA-5635057) p-GLI1 [ciliary tip] (R-HSA-5635040)	0.556	3