pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis

Stable Identifier
R-HSA-200423
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Acetyl-CoA carboxylase 2 (ACACB, ACC2) is involved in the regulation of mitochondrial fatty acid oxidation through the inhibition of carnitine palmitoyltransferase 1 by its product malonyl-CoA. Phosphorylated AMPK inactivates ACACB in muscle cells by phosphorylation. This results in decreased levels of malonyl CoA, contributing to the homeostasis of mitochondrial beta oxidation (Ruderman & Prentki 2004).

Literature References
PubMed ID Title Journal Year
15060529 AMP kinase and malonyl-CoA: targets for therapy of the metabolic syndrome

Ruderman, N, Prentki, M

Nat Rev Drug Discov 2004
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
AMP-activated protein kinase activity of AMPK heterotrimer (active) [cytosol]
Physical Entity
Activity
Orthologous Events
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Created