Reactome: A Curated Pathway Database

5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+

Stable Identifier
R-HSA-200644
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The methylenetetrahydrofolate dehydrogenase activity of the trifunctional MTHFD1 enzyme catalyzes the reversible reaction of 5,10-methyleneTHF polyglutamate and NADP+ to form 5,10-methenylTHF polyglutamate, NADPH, and H+. MTHFD1 is cytosolic and occurs as a dimer. The human enzyme has been identified and partially characterized biochemically (Hum et al. 1988); additional reaction details can be inferred from the properties of the well-studied homologous rabbit enzyme (Villar et al. 1985).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity of 2xMTHFD1 [cytosol] 2xMTHFD1 [cytosol] methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity (0004486)
Orthologous Events