Reactome: A Curated Pathway Database

5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine

Stable Identifier
R-HSA-200651
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Cytosolic serine hydroxymethyltransferase catalyzes the reversible reaction of 5,10-methyleneTHF polyglutamate and glycine to form tetrahydrofolate polyglutamate (THF polyglutamate) and serine. The active form of the enzyme is a tetramer (Renwick et al. 1998).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
glycine hydroxymethyltransferase activity of SHMT1 tetramer [cytosol] SHMT1 tetramer [cytosol] glycine hydroxymethyltransferase activity (0004372)
Orthologous Events