Reactome: A Curated Pathway Database

5,10-methyleneTHF polyglutamate + NADPH + H+ => 5-methylTHF polyglutamate + NADP+

Stable Identifier
R-HSA-200676
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Cytosolic MTHFR dimer catalyzes the reaction of 5,10-methyleneTHF polyglutamate, NADPH, and H+ to form 5-methylTHF polyglutamate and NADP+. The specificity and importance of this reaction in vivo have been established through the study of patients deficient in the enzyme (Goyette et al. 1995).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
methylenetetrahydrofolate reductase (NAD(P)H) activity of 2xMTHFR [cytosol] 2xMTHFR [cytosol] methylenetetrahydrofolate reductase (NAD(P)H) activity (0004489)
Orthologous Events