Extracellular folate import across the plasma membrane

Stable Identifier
R-HSA-200729
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

SLC46A1 protein in the plasma membrane mediates the reversible transport of folate between the extracellular space and the cytosol. Retention of folate within the cell is dependent on polyglutamate addition. Although the SLC46A1 gene is expressed in several tissues in the body, this transporter appears to be primarily needed for absorption of dietary folate from the intestinal lumen (Qiu et al. 2006; Chen et al. 1996).

Literature References
PubMed ID Title Journal Year
8662720 Purification and properties of human cytosolic folylpoly-gamma-glutamate synthetase and organization, localization, and differential splicing of its gene

Chen, L, Qi, H, Korenberg, J, Garrow, TA, Choi, YJ, Shane, B

J Biol Chem 1996
17129779 Identification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorption

Qiu, A, Jansen, M, Sakaris, A, Min, SH, Chattopadhyay, S, Tsai, E, Sandoval, C, Zhao, R, Akabas, MH, Goldman, ID

Cell 2006
Participants
Participant Of
Event Information
Catalyst Activity
Catalyst Activity
Title
folic acid transmembrane transporter activity of SLC46A1 [plasma membrane]
Physical Entity
Activity
Orthologous Events