Reactome: A Curated Pathway Database

Extracellular folate import across the plasma membrane

Stable Identifier
R-HSA-200729
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

SLC46A1 protein in the plasma membrane mediates the reversible transport of folate between the extracellular space and the cytosol. Retention of folate within the cell is dependent on polyglutamate addition. Although the SLC46A1 gene is expressed in several tissues in the body, this transporter appears to be primarily needed for absorption of dietary folate from the intestinal lumen (Qiu et al. 2006; Chen et al. 1996).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
folic acid transporter activity of SLC46A1 [plasma membrane] SLC46A1 [plasma membrane] folic acid transporter activity (0008517)
Orthologous Events