Tetrahydrofolate polyglutamate (THF polyglutamate) + serine <=> 5,10-methyleneTHF polyglutamate + glycine

Stable Identifier
R-HSA-200735
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Cytosolic serine hydroxymethyltransferase catalyzes the reversible reaction of tetrahydrofolate polyglutamate (THF polyglutamate) and serine to form 5,10-methyleneTHF polyglutamate and glycine. The active form of the enzyme is a tetramer (Renwick et al. 1998). In the body, this reaction is a major source of 5,10-methyleneTHF, which in turn is a critical precursor in the synthesis of dTMP.

Literature References
PubMed ID Title Journal Year
9753690 The crystal structure of human cytosolic serine hydroxymethyltransferase: a target for cancer chemotherapy

Renwick, SB, Snell, K, Baumann, U

Structure 1998
Participants
Participant Of
Event Information
Catalyst Activity
Catalyst Activity
Title
glycine hydroxymethyltransferase activity of SHMT1 tetramer [cytosol]
Physical Entity
Activity
Orthologous Events