Reactome: A Curated Pathway Database

5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate

Stable Identifier
R-HSA-200740
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The methenyltetrahydrofolate cyclohydrolase activity of the trifunctional MTHFD1 enzyme catalyzes the reversible reaction of 5,10-methenylTHF polyglutamate and H2O to form 10-formylTHF polyglutamate. MTHFD1 is cytosolic and occurs as a dimer. The human enzyme has been identified and partially characterized biochemically (Hum et al. 1988); additional reaction details can be inferred from the properties of the well-studied homologous rabbit enzyme (Villar et al. 1985).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
methenyltetrahydrofolate cyclohydrolase activity of 2xMTHFD1 [cytosol] 2xMTHFD1 [cytosol] methenyltetrahydrofolate cyclohydrolase activity (0004477)
Orthologous Events