Reactome | BNIP2 [cytosol]

BNIP2 [cytosol]

Stable Identifier

R-HSA-200792

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

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Locations in the PathwayBrowser

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Developmental Biology (Homo sapiens)

- Myogenesis (Homo sapiens)
  - Activation of p38 alpha/beta MAPK (Homo sapiens)
    - p38 alpha/beta/gamma:ABL1:JLP:CDO complex [plasma membrane] (Homo sapiens)
      - ABL1:JLP:CDO complex [plasma membrane] (Homo sapiens)
        
        Cadherin-catenin:JLP:CDO:BOC:Bnip2-Cdc42 [plasma membrane] (Homo sapiens)
        
        Cadherin-catenin:CDO:BOC:Bnip2:CDC42-GTP [plasma membrane] (Homo sapiens)
        
        Cadherin-catenin:CDO:BOC:Bnip2 [plasma membrane] (Homo sapiens)
        
        BNIP2 [cytosol] (Homo sapiens)
    - pp38 alpha/beta/gamma:ABL1:JLP:CDO complex [plasma membrane] (Homo sapiens)
      - ABL1:JLP:CDO complex [plasma membrane] (Homo sapiens)
        
        Cadherin-catenin:JLP:CDO:BOC:Bnip2-Cdc42 [plasma membrane] (Homo sapiens)
        
        Cadherin-catenin:CDO:BOC:Bnip2:CDC42-GTP [plasma membrane] (Homo sapiens)
        
        Cadherin-catenin:CDO:BOC:Bnip2 [plasma membrane] (Homo sapiens)
        
        BNIP2 [cytosol] (Homo sapiens)
  - Bnip2 interacts with CDO complex (Homo sapiens)
    - BNIP2 [cytosol] (Homo sapiens)
    - Cadherin-catenin:CDO:BOC:Bnip2 [plasma membrane] (Homo sapiens)
      - BNIP2 [cytosol] (Homo sapiens)
  - Interaction of ABL1 with CDO complex (Homo sapiens)
    - ABL1:JLP:CDO complex [plasma membrane] (Homo sapiens)
      - Cadherin-catenin:JLP:CDO:BOC:Bnip2-Cdc42 [plasma membrane] (Homo sapiens)
        
        Cadherin-catenin:CDO:BOC:Bnip2:CDC42-GTP [plasma membrane] (Homo sapiens)
        
        Cadherin-catenin:CDO:BOC:Bnip2 [plasma membrane] (Homo sapiens)
        
        BNIP2 [cytosol] (Homo sapiens)
    - Cadherin-catenin:JLP:CDO:BOC:Bnip2-Cdc42 [plasma membrane] (Homo sapiens)
      - Cadherin-catenin:CDO:BOC:Bnip2:CDC42-GTP [plasma membrane] (Homo sapiens)
        
        Cadherin-catenin:CDO:BOC:Bnip2 [plasma membrane] (Homo sapiens)
        
        BNIP2 [cytosol] (Homo sapiens)
  - Interaction of Bnip-2 with Cdc42 (Homo sapiens)
    - Cadherin-catenin:CDO:BOC:Bnip2 [plasma membrane] (Homo sapiens)
      - BNIP2 [cytosol] (Homo sapiens)
    - Cadherin-catenin:CDO:BOC:Bnip2:CDC42-GTP [plasma membrane] (Homo sapiens)
      - Cadherin-catenin:CDO:BOC:Bnip2 [plasma membrane] (Homo sapiens)
        
        BNIP2 [cytosol] (Homo sapiens)
  - Interaction of p38 MAPK with JLP (Homo sapiens)
    - ABL1:JLP:CDO complex [plasma membrane] (Homo sapiens)
      - Cadherin-catenin:JLP:CDO:BOC:Bnip2-Cdc42 [plasma membrane] (Homo sapiens)
        
        Cadherin-catenin:CDO:BOC:Bnip2:CDC42-GTP [plasma membrane] (Homo sapiens)
        
        Cadherin-catenin:CDO:BOC:Bnip2 [plasma membrane] (Homo sapiens)
        
        BNIP2 [cytosol] (Homo sapiens)
    - p38 alpha/beta/gamma:ABL1:JLP:CDO complex [plasma membrane] (Homo sapiens)
      - ABL1:JLP:CDO complex [plasma membrane] (Homo sapiens)
        
        Cadherin-catenin:JLP:CDO:BOC:Bnip2-Cdc42 [plasma membrane] (Homo sapiens)
        
        Cadherin-catenin:CDO:BOC:Bnip2:CDC42-GTP [plasma membrane] (Homo sapiens)
        
        Cadherin-catenin:CDO:BOC:Bnip2 [plasma membrane] (Homo sapiens)
        
        BNIP2 [cytosol] (Homo sapiens)
  - JLP interacts with CDO complex (Homo sapiens)
    - Cadherin-catenin:CDO:BOC:Bnip2:CDC42-GTP [plasma membrane] (Homo sapiens)
      - Cadherin-catenin:CDO:BOC:Bnip2 [plasma membrane] (Homo sapiens)
        
        BNIP2 [cytosol] (Homo sapiens)
    - Cadherin-catenin:JLP:CDO:BOC:Bnip2-Cdc42 [plasma membrane] (Homo sapiens)
      - Cadherin-catenin:CDO:BOC:Bnip2:CDC42-GTP [plasma membrane] (Homo sapiens)
        
        Cadherin-catenin:CDO:BOC:Bnip2 [plasma membrane] (Homo sapiens)
        
        BNIP2 [cytosol] (Homo sapiens)
  - Nuclear translocation of p38 MAPK (Homo sapiens)
    - ABL1:JLP:CDO complex [plasma membrane] (Homo sapiens)
      - Cadherin-catenin:JLP:CDO:BOC:Bnip2-Cdc42 [plasma membrane] (Homo sapiens)
        
        Cadherin-catenin:CDO:BOC:Bnip2:CDC42-GTP [plasma membrane] (Homo sapiens)
        
        Cadherin-catenin:CDO:BOC:Bnip2 [plasma membrane] (Homo sapiens)
        
        BNIP2 [cytosol] (Homo sapiens)
    - pp38 alpha/beta/gamma:ABL1:JLP:CDO complex [plasma membrane] (Homo sapiens)
      - ABL1:JLP:CDO complex [plasma membrane] (Homo sapiens)
        
        Cadherin-catenin:JLP:CDO:BOC:Bnip2-Cdc42 [plasma membrane] (Homo sapiens)
        
        Cadherin-catenin:CDO:BOC:Bnip2:CDC42-GTP [plasma membrane] (Homo sapiens)
        
        Cadherin-catenin:CDO:BOC:Bnip2 [plasma membrane] (Homo sapiens)
        
        BNIP2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q12982 BNIP2

Gene Names

BNIP2, NIP2

Chain

chain:1-314

Reference Genes

BioGPS Gene:663 BNIP2

COSMIC (genes):BNIP2 BNIP2

CTD Gene:663 BNIP2

dbSNP Gene:663 BNIP2

ENSEMBL:ENSG00000140299 BNIP2

HGNC:1083 BNIP2

KEGG:hsa:663 BNIP2

Monarch:663 BNIP2

NCBI Gene:663 BNIP2

OMIM:603292 BNIP2

UCSC:Q12982 BNIP2

Reference Transcript

Other Identifiers

11723670_a_at

11723671_x_at

11748298_a_at

16810040

209308_3p_s_at

209308_PM_s_at

209308_s_at

226280_PM_at

226280_at

243985_PM_at

243985_at

32060_at

3376535

3541371

3627059

3627060

3627061

3627062

3627063

3627064

3627065

3627070

3627072

3627073

3627074

3627075

3627077

3627078

3627079

3627082

3627084

3627085

3627086

3627087

3627088

3627089

3627090

3627093

3627094

3627095

3627096

3627097

3627098

3627099

3627100

3627101

3627102

3627103

3627104

3627105

3627108

3627109

40630_at

64034_at

663

70293_r_at

7989323

A_33_P3227467

A_33_P3400653

GE52956

GE58958

GE735994

GO:0005096

GO:0005509

GO:0005515

GO:0005635

GO:0005730

GO:0005737

GO:0005829

GO:0006915

GO:0012501

GO:0043066

GO:0043226

GO:0043231

GO:0048471

GO:0090649

GO:0098772

HMNXSV003008672

HMNXSV003012494

Hs.24052.0.A1_3p_at

Hs.279528.0.A1_3p_at

ILMN_1770803

PH_hs_0023028

PH_hs_0039982

TC15001503.hg

U15173_at

g12803290_3p_a_at

g12803290_3p_at

g12803290_3p_x_at

Participates

as an input of

Bnip2 interacts with CDO complex (Homo sapiens)

as a component of

Cadherin-catenin:CDO:BOC:Bnip2 [plasma membrane] (Homo sapiens)

Inferred To

bnip2 [cytosol] (Xenopus tropicalis)

Bnip2 [cytosol] (Mus musculus)

Bnip2 [cytosol] (Rattus norvegicus)

BNIP2 [cytosol] (Bos taurus)

BNIP2 [cytosol] (Canis familiaris)

BNIP2 [cytosol] (Gallus gallus)

BNIP2 [cytosol] (Sus scrofa)

anon-EST:Posey64 [cytosol] (Drosophila melanogaster)

Cross References

OpenTargets

ENSG00000140299

ENSEMBL

ENSP00000475320, ENSG00000140299, ENST00000415213, ENSP00000412767, ENST00000607373

GeneCards

BNIP2

HPA

ENSG00000140299-BNIP2

PRO

Q12982

Pharos - Targets

Q12982

GlyGen

Q12982

Interactors (48)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P42685 FRK	4	FRK [specific granule lumen] (R-HSA-6801037) FRK [extracellular region] (R-HSA-6806235) FRK [azurophil granule lumen] (R-HSA-6799142) p-Y387-FRK [cytosol] (R-HSA-8847965)	0.83	8
UniProt:Q969F0 FATE1			0.718	6
UniProt:Q9NUM3 S39A9			0.556	3
UniProt:Q6ZPD8 DGAT2L6	1	DGAT2L6 [endoplasmic reticulum membrane] (R-HSA-8848588)	0.556	3
UniProt:Q96LJ7 DHRS1			0.556	3
UniProt:Q92520 FAM3C	2	FAM3C [extracellular region] (R-HSA-8848922) FAM3C [platelet dense granule lumen] (R-HSA-8848884)	0.556	3
UniProt:Q8TB40 ABHD4	1	ABHD4 [endoplasmic reticulum membrane] (R-HSA-5694582)	0.556	3
UniProt:Q8IUY3 GRM2A			0.556	3
UniProt:Q8N9I0 SYT2	3	SYT2 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869116) SYT2 [plasma membrane] (R-HSA-168795) SYT2 [synaptic vesicle membrane] (R-HSA-194786)	0.556	3
UniProt:O15499 GSC2			0.556	3
UniProt:P50221 MEOX1			0.556	3
UniProt:O15393-2 TMPRSS2			0.556	3
UniProt:Q9NRZ7 AGPAT3	2	AGPAT3 [endoplasmic reticulum membrane] (R-HSA-61807) AGPAT3 [Golgi membrane] (R-HSA-8849239)	0.556	3
UniProt:Q9ULV0-2 MYO5B			0.556	3
UniProt:P00387 CYB5R3	3	CYB5R3(27-301) [azurophil granule lumen] (R-HSA-6799217) CYB5R3(27-301) [extracellular region] (R-HSA-6806205) MyrG-CYB5R3(2-301) [mitochondrial outer membrane] (R-HSA-198771)	0.556	3
UniProt:Q5JX71 F209A			0.556	3
UniProt:O14681 EI24			0.556	3
UniProt:Q8TDF6-2 RASGRP4			0.556	3
UniProt:Q7Z7G2 CPLX4			0.556	3
UniProt:Q96Q45-2 TMEM237			0.556	3
UniProt:O95279 KCNK5	1	KCNK5 [plasma membrane] (R-HSA-1296323)	0.556	3
UniProt:Q5T7V8 GORAB			0.556	3
UniProt:Q07866 KLC1	3	KLC1 [cytosol] (R-HSA-983284) KLC1(1-420)-ALK(1058-1620) fusion [cytosol] (R-HSA-9711968) KLC1(1-420)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711978)	0.556	3
UniProt:Q6FHY5 Q6FHY5			0.556	3
UniProt:O00623 PEX12	2	PEX12 [cytosol] (R-HSA-9603782) PEX12 [peroxisomal membrane] (R-HSA-8953911)	0.556	3
UniProt:Q07866-2 KLC1			0.556	3
UniProt:Q7Z769 S35E3			0.556	3
UniProt:Q9ULV0 MYO5B	1	MYO5B [cytoplasmic vesicle membrane] (R-HSA-2028712)	0.556	5
UniProt:Q8TED1 GPX8	1	GPX8 [endoplasmic reticulum lumen] (R-HSA-3341303)	0.556	3
UniProt:Q9H400 LIME1			0.556	3
UniProt:O95070 YIF1A	1	YIF1A [endoplasmic reticulum membrane] (R-HSA-535599)	0.556	3
UniProt:Q8TBB6 S7A14			0.556	3
UniProt:Q9UH17-2 Q9UH172			0.556	3
UniProt:Q12983 BNIP3			0.556	3
UniProt:Q9Y320 TMX2			0.556	3
UniProt:P32243-2 OTX2			0.556	3
UniProt:P21579 SYT1	7	SYT1 [clathrin-sculpted monoamine transport vesicle membrane] (R-HSA-372508) SYT1 [plasma membrane] (R-HSA-168786) SYT1 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-917741) SYT1 [clathrin-sculpted glutamate transport vesicle membrane] (R-HSA-372514) SYT1 [clathrin-sculpted acetylcholine transport vesicle membrane] (R-HSA-210536) SYT1 [synaptic vesicle membrane] (R-HSA-194789) SYT1 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869113)	0.556	3
UniProt:B2R9H7 B2R9H7			0.556	3
UniProt:Q6P587-2 FAHD1			0.556	3
UniProt:Q8TDT2 GP152			0.556	3
UniProt:P0C671 BNIP5			0.556	3
UniProt:Q9BSY9 DESI2			0.556	3
UniProt:Q53GL0 PKHO1			0.556	3
UniProt:O75477 ERLIN1	1	ERLIN1 [endoplasmic reticulum membrane] (R-HSA-8866518)	0.556	3
UniProt:Q9H9P2 CHODL			0.556	3
UniProt:O95562 SFT2B			0.556	3
UniProt:H3BQL7 H3BQL7			0.556	3
UniProt:Q5T700 LRAD1			0.556	3