THIS SITE IS USED FOR SOFTWARE DEVELOPMENT AND TESTING IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE
THIS SITE IS USED FOR SOFTWARE DEVELOPMENT AND TESTING WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE
The HIV Nef protein downregulates CD4 through sequential connection with clathrin-coated pits and the COP1 coatomer, resulting in accelerated endocytosis and lysosomal targeting. The small GTPase ARF1 controls the Nef-induced, COP-mediated late-endosomal targeting of CD4. Nef binds ARF1 directly and can recruit the GTPase onto endosomal membranes, leading to the eventual degradation of CD4 (Faure et al. 2004).