Reactome | ELMO1 [cytosol]

ELMO1 [cytosol]

Stable Identifier

R-HSA-200932

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Engulfment and cell motility protein 1, ELM1_HUMAN

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Innate Immune System (Homo sapiens)
  - Fcgamma receptor (FCGR) dependent phagocytosis (Homo sapiens)
    - Regulation of actin dynamics for phagocytic cup formation (Homo sapiens)
      - Activation of RAC1 by CRKII:DOCK180:ELMO (Homo sapiens)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Homo sapiens)
        
        ELMO1,ELMO2 [cytosol] (Homo sapiens)
        
        ELMO1 [cytosol] (Homo sapiens)
        
        CRKII:DOCK180:ELMO complex recruited to phagocytic cup [plasma membrane] (Homo sapiens)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Homo sapiens)
        
        ELMO1,ELMO2 [cytosol] (Homo sapiens)
        
        ELMO1 [cytosol] (Homo sapiens)
      - Recruitment of CRKII:DOCK180:ELMO complex to FCGR (Homo sapiens)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Homo sapiens)
        
        ELMO1,ELMO2 [cytosol] (Homo sapiens)
        
        ELMO1 [cytosol] (Homo sapiens)
        
        CRKII:DOCK180:ELMO complex recruited to phagocytic cup [plasma membrane] (Homo sapiens)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Homo sapiens)
        
        ELMO1,ELMO2 [cytosol] (Homo sapiens)
        
        ELMO1 [cytosol] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Signaling by Non-Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by PTK6 (Homo sapiens)
    - PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases (Homo sapiens)
      - Activation of RAC1 by the PXN:CRK complex (Homo sapiens)
        
        p-Y31,Y118-PXN:CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Homo sapiens)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Homo sapiens)
        
        ELMO1,ELMO2 [cytosol] (Homo sapiens)
        
        ELMO1 [cytosol] (Homo sapiens)
      - Phosphorylated PXN recruits the CRK complex (Homo sapiens)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Homo sapiens)
        
        ELMO1,ELMO2 [cytosol] (Homo sapiens)
        
        ELMO1 [cytosol] (Homo sapiens)
        
        p-Y31,Y118-PXN:CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Homo sapiens)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Homo sapiens)
        
        ELMO1,ELMO2 [cytosol] (Homo sapiens)
        
        ELMO1 [cytosol] (Homo sapiens)
- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by VEGF (Homo sapiens)
    - VEGFA-VEGFR2 Pathway (Homo sapiens)
      - DOCK180:ELMO binds CRK (Homo sapiens)
        
        CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Homo sapiens)
        
        ELMO1,ELMO2 [cytosol] (Homo sapiens)
        
        ELMO1 [cytosol] (Homo sapiens)
        
        DOCK180:ELMO1,ELMO2 [cytosol] (Homo sapiens)
        
        ELMO1,ELMO2 [cytosol] (Homo sapiens)
        
        ELMO1 [cytosol] (Homo sapiens)
      - DOCK180:ELMO exchanges GTP for GDP, activating RAC1 (Homo sapiens)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Homo sapiens)
        
        ELMO1,ELMO2 [cytosol] (Homo sapiens)
        
        ELMO1 [cytosol] (Homo sapiens)
        
        CRK:DOCK180:ELMO1,ELMO2:VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-12Y-BCAR1,VEGFA:p-6Y-VEGFR2:p-SHB:p-7Y-PTK2:SRC-1:HSP90:p-Y31,Y118-PXN [plasma membrane] (Homo sapiens)
        
        CRK:DOCK180:ELMO1,ELMO2 [cytosol] (Homo sapiens)
        
        ELMO1,ELMO2 [cytosol] (Homo sapiens)
        
        ELMO1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q92556 ELMO1

Gene Names

ELMO1, KIAA0281

Chain

chain:1-727

Reference Genes

BioGPS Gene:9844 ELMO1

COSMIC (genes):ELMO1 ELMO1

CTD Gene:9844 ELMO1

dbSNP Gene:9844 ELMO1

ENSEMBL:ENSG00000155849 ELMO1

HGNC:16286 ELMO1

KEGG:hsa:9844 ELMO1

Monarch:9844 ELMO1

NCBI Gene:9844 ELMO1

OMIM:606420 ELMO1

UCSC:Q92556 ELMO1

Reference Transcript

Other Identifiers

11729610_a_at

11730851_a_at

11730852_x_at

11749475_a_at

17056740

204513_PM_s_at

204513_s_at

3046196

3046198

3046199

3046202

3046203

3046209

3046213

3046220

3046224

3046251

3046254

3046256

3046261

3046289

3046299

3046300

3046301

3046302

3046320

3046321

3046322

3046323

3046324

3046327

3046330

3046331

3046332

3046333

3046336

3046340

3046342

3046343

3046354

3046358

3046366

3046367

3046376

3046377

3046378

3046379

35633_at

42448_at

7896688

7896704

8139057

8180411

89406_at

9844

A_23_P122937

A_24_P72420

D87457_at

GE57409

GE864558

GO:0005085

GO:0005515

GO:0005737

GO:0005829

GO:0005886

GO:0006909

GO:0006911

GO:0006915

GO:0007010

GO:0007015

GO:0012501

GO:0016020

GO:0016192

GO:0016601

GO:0017124

GO:0030029

GO:0030036

GO:0032045

GO:0048870

GO:0061024

GO:0098772

GO:0098794

GO:0098978

GO:0150052

HMNXSV003039286

ILMN_1663627

ILMN_1740231

ILMN_1784320

ILMN_2379527

PH_hs_0025985

TC07001288.hg

TC07002893.hg

g7662037_3p_a_at

p33716

Participates

as a component of

DOCK2:ELMO1:RAC1:Nef Complex [cytosol] (Homo sapiens)

as an input of

Nef binds a ternary complex comprising DOCK2 guanine nucleotide exchange factor for small Rho-family GTPase Rac, its cofactor ELMO1, and Rac, and activates Rac through this interaction (Homo sapiens)

as a member of

ELMO1,ELMO2 [cytosol] (Homo sapiens)

Inferred To

elmoF [cytosol] (Dictyostelium discoideum)

Ced-12 [cytosol] (Drosophila melanogaster)

elmo1 [cytosol] (Xenopus tropicalis)

Elmo1 [cytosol] (Mus musculus)

Elmo1 [cytosol] (Rattus norvegicus)

Homologues of ELMO1 [cytosol] (Dictyostelium discoideum)

elmoE [cytosol] (Dictyostelium discoideum)

ELMO1 [cytosol] (Bos taurus)

ELMO1 [cytosol] (Canis familiaris)

ELMO1 [cytosol] (Gallus gallus)

ELMO1 [cytosol] (Sus scrofa)

LMO1 [cytosol] (Saccharomyces cerevisiae)

ced-12 [cytosol] (Caenorhabditis elegans)

elmoC [cytosol] (Dictyostelium discoideum)

Cross References

RefSeq

XP_016868327.1, NP_001193411.1, NP_569709.1, XP_005249976.1, NP_001034548.1, NP_001193409.1, XP_011513956.1, XP_016868328.1, XP_006715868.1, NP_055615.8

OpenTargets

ENSG00000155849

ENSEMBL

ENSP00000379360, ENST00000442504, ENST00000310758, ENSP00000406952, ENSP00000394458, ENSP00000379355, ENST00000396040, ENSP00000312185, ENST00000396045, ENST00000448602

HPA

ENSG00000155849-ELMO1

PRO

Q92556

Pharos - Targets

Q92556

GlyGen

Q92556

PDB

7DPA, 7Y4A, 6TGC, 6JPP, 2VSZ, 6TGB, 2RQR, 8JHK, 3A98

HMDB Protein

HMDBP11495

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q14185 DOCK1	1	DOCK1 [cytosol] (R-HSA-372654)	0.937	20
UniProt:Q8TD17 ZNF398	1	ZNF398 [nucleoplasm] (R-HSA-1247512)	0.801	6
UniProt:Q8IZD9 DOCK3	1	DOCK3 [cytosol] (R-HSA-1012973)	0.643	4
UniProt:P84095 RHOG	4	RHOG [endoplasmic reticulum membrane] (R-HSA-5672084) RHOG [secretory granule membrane] (R-HSA-6804965) RHOG [cytosol] (R-HSA-194909) RHOG [plasma membrane] (R-HSA-194880)	0.623	4
UniProt:P63000 RAC1	6	RAC1 [plasma membrane] (R-HSA-351141) RAC1 [cytosol] (R-HSA-442615) GGC-PalmC-RAC1 [plasma membrane] (R-HSA-2316446) RAC1 [ficolin-1-rich granule membrane] (R-HSA-6804802) RAC1 [secretory granule membrane] (R-HSA-6804770) RAC1 [endoplasmic reticulum membrane] (R-HSA-5672076)	0.564	4
UniProt:Q9BYV2 TRI54			0.556	3
UniProt:P07355 ANXA2	6	ANXA2 [azurophil granule lumen] (R-HSA-6798766) ANXA2 [extracellular region] (R-HSA-6806242) p-S26-ANXA2 [cytosol] (R-HSA-9865163) p-Y24,S26-ANXA2 [cytosol] (R-HSA-9865224) ANXA2 [external side of plasma membrane] (R-HSA-5336164) ANXA2 [cytosol] (R-HSA-5263667)	0.537	3
UniProt:Q9Y3C7 MED31	1	MED31 [nucleoplasm] (R-HSA-212429)	0.527	2
UniProt:P27482 CALL3			0.527	2
UniProt:Q96JJ3 ELMO2	1	ELMO2 [cytosol] (R-HSA-372642)	0.527	3
UniProt:P08631 HCK	2	p-HCK [cytosol] (R-HSA-9676060) HCK [cytosol] (R-HSA-167708)	0.524	4