FGFR1 R576W [plasma membrane]

Stable Identifier
R-HSA-2011844
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
FGFR1 R576W [plasma membrane] icon
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
16186508 Sequence survey of receptor tyrosine kinases reveals mutations in glioblastomas

Rand, V, Huang, J, Stockwell, T, Ferriera, S, Buzko, O, Levy, S, Busam, D, Li, K, Edwards, JB, Eberhart, C, Murphy, KM, Tsiamouri, A, Beeson, K, Simpson, AJ, Venter, JC, Riggins, GJ, Strausberg, RL

Proc Natl Acad Sci U S A 2005
External Reference Information
External Reference
Gene Names
FGFR1, BFGFR, CEK, FGFBR, FLG, FLT2, HBGFR
Chain
signal peptide:1-21, chain:22-822
Other Identifiers
0003360142
0005220121
11716548_x_at
11727300_a_at
11727301_a_at
11734765_a_at
11747416_a_at
11747417_x_at
2056_at
2057_g_at
207937_x_at
211535_s_at
2260
226705_at
3132013
3132015
3132017
3132018
3132019
3132020
3132021
3132022
3132023
3132025
3132026
3132027
3132028
3132029
3132031
3132033
3132036
3132039
3132041
3132044
3132046
3132055
3132056
3132070
3132072
3132076
3132078
3132080
3132081
3132083
3132095
3132108
3132109
3132111
3132112
3132113
3132114
3132115
3132116
3493097
36168_at
424_s_at
53212_at
8150318
91005_at
A_23_P301304
A_23_P372923
A_24_P4171
GE59934
GO:0000122
GO:0000165
GO:0000166
GO:0000278
GO:0001501
GO:0001525
GO:0001657
GO:0001701
GO:0001759
GO:0001764
GO:0002053
GO:0002062
GO:0003674
GO:0004672
GO:0004713
GO:0004714
GO:0005007
GO:0005515
GO:0005524
GO:0005575
GO:0005576
GO:0005622
GO:0005634
GO:0005737
GO:0005829
GO:0005886
GO:0005887
GO:0006464
GO:0006468
GO:0006629
GO:0006810
GO:0007049
GO:0007165
GO:0007169
GO:0007267
GO:0007275
GO:0007420
GO:0007435
GO:0007605
GO:0008150
GO:0008201
GO:0008219
GO:0008283
GO:0008284
GO:0008543
GO:0009058
GO:0009790
GO:0010468
GO:0010518
GO:0010629
GO:0010863
GO:0010966
GO:0010976
GO:0014068
GO:0016020
GO:0016021
GO:0016301
GO:0016310
GO:0016477
GO:0016740
GO:0017134
GO:0018108
GO:0021700
GO:0021769
GO:0021847
GO:0030154
GO:0030324
GO:0030326
GO:0030901
GO:0031410
GO:0032991
GO:0033674
GO:0034641
GO:0035607
GO:0040007
GO:0040011
GO:0042127
GO:0042169
GO:0042472
GO:0042473
GO:0042474
GO:0042802
GO:0042803
GO:0043009
GO:0043167
GO:0043226
GO:0043235
GO:0043406
GO:0043410
GO:0043536
GO:0043583
GO:0044281
GO:0045595
GO:0045597
GO:0045666
GO:0045787
GO:0046777
GO:0048015
GO:0048339
GO:0048378
GO:0048469
GO:0048514
GO:0048646
GO:0048699
GO:0048705
GO:0048762
GO:0048856
GO:0048870
GO:0050877
GO:0051174
GO:0051301
GO:0051897
GO:0060045
GO:0060117
GO:0060445
GO:0060484
GO:0060665
GO:0070640
GO:0090080
GO:0090272
GO:0090722
GO:1903465
GO:1905564
GO:2000546
GO:2000830
GO:2001239
Hs.748.8.A1_3p_at
ILMN_1729369
ILMN_1796229
ILMN_2398261
PH_hs_0000085
X66945_at
g13186246_3p_a_at
g182560_3p_a_at
Participant Of
Other forms of this molecule
Modified Residues
Name
L-arginine 576 replaced with L-tryptophan
Coordinate
576
PsiMod
A protein modification that effectively removes or replaces an L-arginine.
A protein modification that effectively converts a source amino acid residue to L-tryptophan.
Disease
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer
glioblastoma 3068 spongioblastoma multiforme, Spongioblastoma multiforme, primary glioblastoma multiforme, Glioblastoma multiforme, Glioblastoma (morphologic abnormality), GBM (Glioblastoma), Glioblastoma NOS (morphologic abnormality)
Interactors (12)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P19174 PLCG1  6 0.872 9
 UniProt:P09038 FGF2  1 0.871 7
 UniProt:P46934 NEDD4  1 0.672 26
 UniProt:P23352 ANOS1  1 0.626 7
 UniProt:P27986 PIK3R1  15 0.623 5
 UniProt:P10686 Plcg1  8 0.611 4
 UniProt:P35222 CTNNB1  33 0.589 2
 UniProt:P12830 CDH1  10 0.589 3
 UniProt:P46108 CRK  1 0.564 2
 UniProt:P08238 HSP90AB1  6 0.564 2
 UniProt:Q9GZV9 FGF23  6 0.544 2
 UniProt:O88900  1 0.524 3
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