Formation of the hetero-tetrameric BMP2:receptor complex induces receptor rotation, so that their cytoplasmic kinase domains face each other in a catalytically favourable configuration. The constitutively active type II receptor kinase (which auto-phosphorylates in the absence of ligand), trans-phosphorylates specific serine residues at the conserved Gly-Ser-rich juxtapositioned domain of the type I receptor. It is not known if exactly 8 ATPs are required for the phosphorylation of type I receptor, there could be more or less than this number.
Rosenzweig, BL, Imamura, T, Okadome, T, Cox, GN, Yamashita, H, ten Dijke, P, Heldin, CH, Miyazono, K
Liu, F, Ventura, F, Doody, J, Massague, J
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