Reactome: A Curated Pathway Database

Type II receptor phosphorylates type I receptor

Stable Identifier
R-HSA-201443
Type
Reaction
Species
Homo sapiens
Compartment
cytosol, plasma membrane
Locations in the PathwayBrowser
Summation

Formation of the hetero-tetrameric BMP2:receptor complex induces receptor rotation, so that their cytoplasmic kinase domains face each other in a catalytically favourable configuration. The constitutively active type II receptor kinase (which auto-phosphorylates in the absence of ligand), trans-phosphorylates specific serine residues at the conserved Gly-Ser-rich juxtapositioned domain of the type I receptor. It is not known if exactly 8 ATPs are required for the phosphorylation of type I receptor, there could be more or less than this number.

Literature References
PubMed ID Title Journal Year
7644468 Cloning and characterization of a human type II receptor for bone morphogenetic proteins Proc Natl Acad Sci U S A 1995
7791754 Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs Mol Cell Biol 1995
Participants
input
output
Participant Of
hasEvent
This entity is regulated by:
Title Physical Entity Activity
activin receptor activity, type II of BMP:BMPRII:BMPRI [plasma membrane] BMP:BMPRII:BMPRI [plasma membrane] activin receptor activity, type II (0016362)
Orthologous Events
 
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