Reactome | Type II receptor phosphorylates type I receptor

Type II receptor phosphorylates type I receptor

Stable Identifier

R-HSA-201443

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

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Type II receptor phosphorylates type I receptor

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Formation of the hetero-tetrameric BMP2:receptor complex induces receptor rotation, so that their cytoplasmic kinase domains face each other in a catalytically favourable configuration. The constitutively active type II receptor kinase (which auto-phosphorylates in the absence of ligand), trans-phosphorylates specific serine residues at the conserved Gly-Ser-rich juxtapositioned domain of the type I receptor. It is not known if exactly 8 ATPs are required for the phosphorylation of type I receptor, there could be more or less than this number.

Literature References

PubMed ID	Title	Journal	Year
7644468	Cloning and characterization of a human type II receptor for bone morphogenetic proteins Rosenzweig, BL, Imamura, T, Okadome, T, Cox, GN, Yamashita, H, ten Dijke, P, Heldin, CH, Miyazono, K	Proc Natl Acad Sci U S A	1995
7791754	Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs Liu, F, Ventura, F, Doody, J, Massague, J	Mol Cell Biol	1995