Reactome: A Curated Pathway Database

Type II receptor phosphorylates type I receptor

Stable Identifier
R-HSA-201443
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Formation of the hetero-tetrameric BMP2:receptor complex induces receptor rotation, so that their cytoplasmic kinase domains face each other in a catalytically favourable configuration. The constitutively active type II receptor kinase (which auto-phosphorylates in the absence of ligand), trans-phosphorylates specific serine residues at the conserved Gly-Ser-rich juxtapositioned domain of the type I receptor. It is not known if exactly 8 ATPs are required for the phosphorylation of type I receptor, there could be more or less than this number.

Literature References
Participants
Participant Of
hasEvent
This entity is regulated by:
Title Physical Entity Activity
activin receptor activity, type II of BMP:BMPRII:BMPRI [plasma membrane] BMP:BMPRII:BMPRI [plasma membrane] activin receptor activity, type II (0016362)
Orthologous Events