Reactome | Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8

Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8

Stable Identifier

R-HSA-201445

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol

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Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8

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SMAD2 is polyubiquitinated by SMURF2 and targeted for proteasome-mediated degradation.

Literature References

PubMed ID	Title	Journal	Year
11016919	Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling Lin, X, Liang, M, Feng, XH	J Biol Chem	2000
10458166	A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation Zhu, H, Kavsak, P, Abdollah, S, Wrana, JL, Thomsen, GH	Nature	1999
11158580	Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase Zhang, Y, Chang, C, Gehling, DJ, Hemmati-Brivanlou, A, Derynck, R	Proc Natl Acad Sci U S A	2001