Reactome | Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8

Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8

Stable Identifier

R-HSA-201445

Type

Reaction [BlackBoxEvent]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

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Summation

SMAD2 is polyubiquitinated by SMURF2 and targeted for proteasome-mediated degradation.

Literature References

PubMed ID	Title	Journal	Year
11016919	Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling	J Biol Chem	2000
10458166	A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation	Nature	1999
11158580	Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase	Proc Natl Acad Sci U S A	2001

Participants

Input

SMAD1/5/8 [cytosol] (Homo sapiens)

Participant Of

hasEvent

Signaling by BMP

Catalyst Activity

Catalyst Activity

Title

ubiquitin protein ligase activity of SMURF [cytosol]

Physical Entity

SMURF [cytosol]

Activity

ubiquitin protein ligase activity (0061630)

Orthologous Events

Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 (Bos taurus)

Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 (Canis familiaris)

Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 (Danio rerio)

Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 (Drosophila melanogaster)

Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 (Gallus gallus)

Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 (Mus musculus)

Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 (Rattus norvegicus)

Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 (Sus scrofa)

Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 (Taeniopygia guttata)

Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 (Xenopus tropicalis)

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