Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8

Stable Identifier
R-HSA-201445
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

SMAD2 is polyubiquitinated by SMURF2 and targeted for proteasome-mediated degradation.

Literature References
PubMed ID Title Journal Year
11016919 Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling

Lin, X, Liang, M, Feng, XH

J Biol Chem 2000
10458166 A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation

Zhu, H, Kavsak, P, Abdollah, S, Wrana, JL, Thomsen, GH

Nature 1999
11158580 Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase

Zhang, Y, Chang, C, Gehling, DJ, Hemmati-Brivanlou, A, Derynck, R

Proc Natl Acad Sci U S A 2001
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
ubiquitin protein ligase activity of SMURF [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed