Reactome | Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8

Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8

Stable Identifier

R-HSA-201445

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8

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SMAD2 is polyubiquitinated by SMURF2 and targeted for proteasome-mediated degradation.

Literature References

PubMed ID	Title	Journal	Year
10458166	A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation Thomsen, GH, Wrana, JL, Zhu, H, Abdollah, S, Kavsak, P	Nature	1999
11016919	Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling Liang, M, Lin, X, Feng, XH	J Biol Chem	2000
11158580	Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase Zhang, Y, Gehling, DJ, Chang, C, Hemmati-Brivanlou, A, Derynck, R	Proc Natl Acad Sci U S A	2001