Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8

Stable Identifier
R-HSA-201445
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
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Summation

SMAD2 is polyubiquitinated by SMURF2 and targeted for proteasome-mediated degradation.

Literature References
PubMed ID Title Journal Year
11016919 Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling

Lin, X, Liang, M, Feng, XH

J Biol Chem 2000
10458166 A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation

Zhu, H, Kavsak, P, Abdollah, S, Wrana, JL, Thomsen, GH

Nature 1999
11158580 Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase

Zhang, Y, Chang, C, Gehling, DJ, Hemmati-Brivanlou, A, Derynck, R

Proc Natl Acad Sci U S A 2001
Participants
Input
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
ubiquitin protein ligase activity of SMURF [cytosol]
Physical Entity
SMURF [cytosol]
Activity
ubiquitin protein ligase activity (0061630)
Orthologous Events
Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 (Bos taurus)
Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 (Canis familiaris)
Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 (Danio rerio)
Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 (Drosophila melanogaster)
Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 (Gallus gallus)
Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 (Mus musculus)
Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 (Rattus norvegicus)
Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 (Sus scrofa)
Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 (Taeniopygia guttata)
Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 (Xenopus tropicalis)
Authored
Huminiecki, L  (2007-11-07)
Moustakas, A  (2007-11-07)
Reviewed
Heldin, CH  (2007-11-12)