Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8

Stable Identifier
R-HSA-201445
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

SMAD2 is polyubiquitinated by SMURF2 and targeted for proteasome-mediated degradation.

Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
ubiquitin protein ligase activity of SMURF [cytosol]
Physical Entity
Activity
Orthologous Events