Reactome: A Curated Pathway Database

Phospho-R-Smad1/5/8 dissociates from the receptor complex

Stable Identifier
R-HSA-201453
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Upon phosphorylation of the R-SMAD (SMAD2/3), the conformation of the C-terminal (MH2) domain of the R-SMAD changes, lowering its affinity for the type I receptor and ZFYVE9 (SARA). As a result, the phosphorylated R-SMAD dissociates from the activated receptor complex (TGFBR).

Literature References
Participants
Participant Of
hasEvent
Orthologous Events