Reactome | Phospho-R-Smad1/5/8 dissociates from the receptor complex

Phospho-R-Smad1/5/8 dissociates from the receptor complex

Stable Identifier

R-HSA-201453

Type

Reaction [dissociation]

Species

Homo sapiens

Compartment

early endosome

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Phospho-R-Smad1/5/8 dissociates from the receptor complex

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Upon phosphorylation of the R-SMAD (SMAD2/3), the conformation of the C-terminal (MH2) domain of the R-SMAD changes, lowering its affinity for the type I receptor and ZFYVE9 (SARA). As a result, the phosphorylated R-SMAD dissociates from the activated receptor complex (TGFBR).

Literature References

PubMed ID	Title	Journal	Year
9136927	The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase Massague, J, Kretzschmar, M, Doody, J, Liu, F, Hata, A	Genes Dev	1997
8893010	Partnership between DPC4 and SMAD proteins in TGF-beta signalling pathways Massague, J, Lagna, G, Hemmati-Brivanlou, A, Hata, A	Nature	1996
17356069	Endofin acts as a Smad anchor for receptor activation in BMP signaling Cao, X, Chang, C, Nie, S, Wan, M, Shi, W, Xie, S	J Cell Sci	2007