Reactome | BMP2 [extracellular region]

BMP2 [extracellular region]

Stable Identifier

R-HSA-201456

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Bone morphogenetic protein 2, BMP2_HUMAN

Icon

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P12643 BMP2

Gene Names

BMP2, BMP2A

Chain

signal peptide:1-23, propeptide:24-282, chain:283-396

Reference Genes

BioGPS Gene:650 BMP2

COSMIC (genes):BMP2 BMP2

CTD Gene:650 BMP2

dbSNP Gene:650 BMP2

ENSEMBL:ENSG00000125845 BMP2

HGNC:1069 BMP2

KEGG Gene (Homo sapiens):650 BMP2

Monarch:650 BMP2

NCBI Gene:650 BMP2

OMIM:112261 BMP2

UCSC:P12643 BMP2

Reference Transcript

RefSeq:NM_001200.3 BMP2

Other Identifiers

0003830184

1113_at

11743497_at

11743498_at

16911261

205289_at

205290_s_at

3875422

3875424

3875425

3875426

3875427

3875428

3875430

3875431

3875432

3875435

3875436

3875437

40367_at

59306_at

650

8060850

A_23_P143331

A_33_P3237150

A_33_P3346543

GE57870

GO:0000122

GO:0000187

GO:0001501

GO:0001503

GO:0001649

GO:0001658

GO:0001666

GO:0001701

GO:0001837

GO:0001934

GO:0001938

GO:0002062

GO:0003130

GO:0003181

GO:0003203

GO:0003308

GO:0003674

GO:0004745

GO:0005102

GO:0005125

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005886

GO:0006029

GO:0006355

GO:0006464

GO:0006468

GO:0006629

GO:0006950

GO:0006954

GO:0007049

GO:0007155

GO:0007165

GO:0007219

GO:0007267

GO:0007275

GO:0007507

GO:0008083

GO:0008150

GO:0008219

GO:0008283

GO:0008285

GO:0009058

GO:0009617

GO:0009790

GO:0009887

GO:0009986

GO:0010628

GO:0010629

GO:0010718

GO:0010862

GO:0010894

GO:0010922

GO:0016491

GO:0019211

GO:0021537

GO:0021700

GO:0021978

GO:0030154

GO:0030177

GO:0030234

GO:0030282

GO:0030335

GO:0030501

GO:0030509

GO:0031648

GO:0032092

GO:0032348

GO:0032991

GO:0033690

GO:0034641

GO:0035051

GO:0035054

GO:0035630

GO:0039706

GO:0040011

GO:0042475

GO:0042482

GO:0042487

GO:0043065

GO:0043226

GO:0043231

GO:0043410

GO:0043569

GO:0044281

GO:0045165

GO:0045597

GO:0045600

GO:0045666

GO:0045669

GO:0045778

GO:0045786

GO:0045892

GO:0045893

GO:0045944

GO:0046332

GO:0048646

GO:0048711

GO:0048762

GO:0048839

GO:0048856

GO:0048870

GO:0051042

GO:0051216

GO:0055007

GO:0055008

GO:0055114

GO:0060039

GO:0060128

GO:0060129

GO:0060317

GO:0060389

GO:0060395

GO:0060485

GO:0060804

GO:0061036

GO:0070374

GO:0070700

GO:0070724

GO:0071363

GO:0071407

GO:0071773

GO:0072138

GO:0090090

GO:1900745

GO:1901522

GO:1902895

GO:2000065

GO:2000726

Hs.73853.0.S2_3p_at

ILMN_1722718

M22489_at

PH_hs_0004220

TC20000067.hg

g4557368_3p_a_at

Participant Of

hasComponent

BMP2 dimer [extracellular region]

Other forms of this molecule

BMP2(24-396) [extracellular region]

Inferred To

dbl-1 [extracellular region] (Caenorhabditis elegans)

BMP2 [extracellular region] (Canis familiaris)

BMP2 [extracellular region] (Sus scrofa)

bmp2 [extracellular region] (Xenopus tropicalis)

Ghost homologue of BMP2 [extracellular region] (Gallus gallus)

Bmp2 [extracellular region] (Mus musculus)

Bmp2 [extracellular region] (Rattus norvegicus)

bmp2b [extracellular region] (Danio rerio)

dpp [extracellular region] (Drosophila melanogaster)

Cross References

RefSeq

NP_001191.1

Target Pathogen

5b354852be737e166372ecdb

OpenTargets

ENSG00000125845

HPA

ENSG00000125845-BMP2

GeneCards

P12643

Ensembl

ENSP00000368104, ENSG00000125845, ENST00000378827

ZINC target

P12643

PRO

P12643

Orphanet

18080

HMDB Protein

HMDBP02308

PDB

1REU, 1ES7, 4N1D, 4MID, 4UHY, 1REW, 2QJ9, 4UHZ, 2H62, 2H64, 4UI0, 2GOO, 4UI1, 2QJA, 2QJB, 6OMN, 3BK3, 3BMP, 4UI2

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P97798 Neo1	1	Neogenin [plasma membrane] (R-MMU-421657)	0.602	3
UniProt:P27038 Acvr2a	1	Acvr2a [plasma membrane] (R-MMU-1225869)	0.544	2

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