Reactome | BMP2 binds to the receptor complex

BMP2 binds to the receptor complex

Stable Identifier

R-HSA-201457

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

4/5

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The mature dimeric BMP2 binds with high affinity to its signalling receptor, the type II receptor serine/threonine kinase. The type II receptor is known to form dimeric complexes even in the absence of BMP2 (Rosenzweig et al.1995). Also, TGFBR3 (Betaglycan) antagonises BMP2 signalling by binding with ACVR2A (ActRII). TGFBR3 and BMP2 compete for ACVR2A and TGFBR3 thus inhibits BMP2 signalling (Waiter et al. 2003).

Literature References

PubMed ID	Title	Journal	Year
7644468	Cloning and characterization of a human type II receptor for bone morphogenetic proteins Rosenzweig, BL, Imamura, T, Okadome, T, Cox, GN, Yamashita, H, ten Dijke, P, Heldin, CH, Miyazono, K	Proc Natl Acad Sci U S A	1995