Reactome: A Curated Pathway Database

BMP2 binds to the receptor complex

Stable Identifier
R-HSA-201457
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The mature dimeric BMP2 binds with high affinity to its signalling receptor, the type II receptor serine/threonine kinase. The type II receptor is known to form dimeric complexes even in the absence of BMP2 (Rosenzweig et al.1995).

Literature References
PubMed ID Title Journal Year
Participants
Participant Of
hasEvent
This entity is regulated by:
Title Physical Entity Activity
transforming growth factor beta receptor binding activity of BMP2 dimer [extracellular region] BMP2 dimer [extracellular region] transforming growth factor beta receptor binding (0005160)
Orthologous Events