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p-S465,S467-SMAD9 [nucleoplasm]
Stable Identifier
R-HSA-201474
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Phospho-R-SMAD9, Mothers against decapentaplegic homolog 9, SMA9_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by TGFB family members (Homo sapiens)
Signaling by BMP (Homo sapiens)
SKI complexes with the Smad complex, suppressing BMP2 signalling (Homo sapiens)
p-2S-SMAD1/5/8:SMAD4 [nucleoplasm] (Homo sapiens)
Phospho-R-SMAD1/5/9 [nucleoplasm] (Homo sapiens)
p-S465,S467-SMAD9 [nucleoplasm] (Homo sapiens)
p-2S-SMAD1/5/8:SMAD4:SKI [nucleoplasm] (Homo sapiens)
p-2S-SMAD1/5/8:SMAD4 [nucleoplasm] (Homo sapiens)
Phospho-R-SMAD1/5/9 [nucleoplasm] (Homo sapiens)
p-S465,S467-SMAD9 [nucleoplasm] (Homo sapiens)
The phospho-R-Smad1/5/8:Co-Smad transfers to the nucleus (Homo sapiens)
p-2S-SMAD1/5/8:SMAD4 [nucleoplasm] (Homo sapiens)
Phospho-R-SMAD1/5/9 [nucleoplasm] (Homo sapiens)
p-S465,S467-SMAD9 [nucleoplasm] (Homo sapiens)
Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling (Homo sapiens)
p-2S-SMAD1/5/8:SMAD4 [nucleoplasm] (Homo sapiens)
Phospho-R-SMAD1/5/9 [nucleoplasm] (Homo sapiens)
p-S465,S467-SMAD9 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O15198 SMAD9
Gene Names
SMAD9, MADH6, MADH9, SMAD8
Chain
chain:1-467
Reference Genes
BioGPS Gene:4093 SMAD9
COSMIC (genes):SMAD9 SMAD9
CTD Gene:4093 SMAD9
dbSNP Gene:4093 SMAD9
ENSEMBL:ENSG00000120693 SMAD9
ENSEMBL:ENSG00000120693.14 SMAD9
HGNC:6774 SMAD9
KEGG Gene (Homo sapiens):4093 SMAD9
Monarch:4093 SMAD9
NCBI Gene:4093 SMAD9
OMIM:603295 SMAD9
UCSC:O15198 SMAD9
Reference Transcript
RefSeq:NM_001127217.2 SMAD9
RefSeq:NM_005905.5 SMAD9
Other Identifiers
11740220_a_at
16778155
206320_PM_s_at
206320_s_at
227719_PM_at
227719_at
32986_s_at
3509839
3509841
3509843
3509844
3509846
3509849
3509850
3509851
3509853
3509854
3509856
3509857
3509864
4093
49904_at
50572_at
7971015
84856_at
84925_at
92002_at
A_23_P2814
A_24_P655849
GE474588
GO:0000785
GO:0000978
GO:0000981
GO:0003677
GO:0005515
GO:0005634
GO:0005654
GO:0005667
GO:0005694
GO:0005737
GO:0005829
GO:0006351
GO:0006355
GO:0006357
GO:0007179
GO:0009653
GO:0010468
GO:0023052
GO:0030154
GO:0030509
GO:0043226
GO:0046872
GO:0048856
GO:0060395
GO:0070411
GO:0071141
GO:0071144
GO:0071773
GO:0140110
GO:1901522
HMNXSV003032690
HMNXSV003041497
Hs.103262.0.S1_3p_at
ILMN_1815385
PH_hs_0006905
TC13000569.hg
g5174518_3p_a_at
Participates
as a member of
Phospho-R-SMAD1/5/9 [nucleoplasm] (Homo sapiens)
Other forms of this molecule
p-S465,S467-SMAD9 [cytosol]
SMAD9 [cytosol]
Inferred To
phospho-daf-14 [nucleoplasm]
(Caenorhabditis elegans)
phospho-p-S465,S467-SMAD9 [nucleoplasm]
(Caenorhabditis elegans)
phospho-p-S465,S467-SMAD9 [nucleoplasm]
(Canis familiaris)
phospho-p-S465,S467-SMAD9 [nucleoplasm]
(Drosophila melanogaster)
phospho-p-S465,S467-SMAD9 [nucleoplasm]
(Mus musculus)
phospho-p-S465,S467-SMAD9 [nucleoplasm]
(Rattus norvegicus)
phospho-sma8 [nucleoplasm]
(Danio rerio)
phospho-SMAD9 [nucleoplasm]
(Bos taurus)
phospho-SMAD9 [nucleoplasm]
(Sus scrofa)
phospho-smad9 [nucleoplasm]
(Xenopus tropicalis)
Homologues of p-S465,S467-SMAD9 [nucleoplasm]
(Caenorhabditis elegans)
Modified Residues
Name
O-phospho-L-serine at 465
Coordinate
465
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 467
Coordinate
467
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_001120689.1
,
NP_005896.1
OpenTargets
ENSG00000120693
GeneCards
O15198
HPA
ENSG00000120693-SMAD9
Ensembl
ENST00000350148
,
ENST00000379826
,
ENSG00000120693
,
ENSP00000369154
,
ENSP00000239885
PRO
O15198
Pharos - Targets
O15198
Orphanet
18370
PDB
6FZT
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13485 SMAD4
20
SMAD4 P356R [cytosol]
(R-HSA-3310988)
SMAD4 K428T [cytosol]
(R-HSA-3311004)
SMAD4 D351del [cytosol]
(R-HSA-3310974)
SMAD4 R361H [cytosol]
(R-HSA-3310984)
SMAD4 P356L [cytosol]
(R-HSA-3310987)
SMAD4 A406T [cytosol]
(R-HSA-3311003)
SMAD4 D351Y [cytosol]
(R-HSA-3310970)
SMAD4 D351H [cytosol]
(R-HSA-3310965)
SMAD4 R361C [cytosol]
(R-HSA-3310983)
SMAD4 D351G [cytosol]
(R-HSA-3310967)
SMAD4 R515T [cytosol]
(R-HSA-3311008)
SMAD4 G352* [cytosol]
(R-HSA-9678445)
SMAD4 S178* [cytosol]
(R-HSA-9675630)
SMAD4 G477* [cytosol]
(R-HSA-9678447)
SMAD4 G473* [cytosol]
(R-HSA-9678440)
SMAD4 S144* [cytosol]
(R-HSA-9675625)
SMAD4 E538* [cytosol]
(R-HSA-9675626)
SMAD4 E390* [cytosol]
(R-HSA-9675620)
SMAD4 S154* [cytosol]
(R-HSA-9675621)
SMAD4 E330* [cytosol]
(R-HSA-9675622)
0.748
4
UniProt:O60341 KDM1A
1
KDM1A [nucleoplasm]
(R-HSA-996769)
0.508
2
UniProt:Q96LA8 PRMT6
1
PRMT6 [nucleoplasm]
(R-HSA-5226884)
0.508
2
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