Reactome | p-S465,S467-SMAD9 [nucleoplasm]

p-S465,S467-SMAD9 [nucleoplasm]

Stable Identifier

R-HSA-201474

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Phospho-R-SMAD9, Mothers against decapentaplegic homolog 9, SMA9_HUMAN

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External Reference Information

External Reference

UniProt:O15198 SMAD9

Gene Names

SMAD9, MADH6, MADH9, SMAD8

Chain

chain:1-467

Reference Genes

BioGPS Gene:4093 SMAD9

COSMIC (genes):SMAD9 SMAD9

CTD Gene:4093 SMAD9

dbSNP Gene:4093 SMAD9

ENSEMBL:ENSG00000120693 SMAD9

ENSEMBL:ENSG00000120693.14 SMAD9

HGNC:6774 SMAD9

KEGG Gene (Homo sapiens):4093 SMAD9

Monarch:4093 SMAD9

NCBI Gene:4093 SMAD9

OMIM:603295 SMAD9

UCSC:O15198 SMAD9

Reference Transcript

Other Identifiers

11740220_a_at

16778155

206320_PM_s_at

206320_s_at

227719_PM_at

227719_at

32986_s_at

3509839

3509841

3509843

3509844

3509846

3509849

3509850

3509851

3509853

3509854

3509856

3509857

3509864

4093

49904_at

50572_at

7971015

84856_at

84925_at

92002_at

A_23_P2814

A_24_P655849

GE474588

GO:0000785

GO:0000978

GO:0000981

GO:0003677

GO:0005515

GO:0005634

GO:0005654

GO:0005667

GO:0005694

GO:0005737

GO:0005829

GO:0006351

GO:0006355

GO:0006357

GO:0007179

GO:0009653

GO:0010468

GO:0023052

GO:0030154

GO:0030509

GO:0043226

GO:0046872

GO:0048856

GO:0060395

GO:0070411

GO:0071141

GO:0071144

GO:0071773

GO:0140110

GO:1901522

HMNXSV003032690

HMNXSV003041497

Hs.103262.0.S1_3p_at

ILMN_1815385

PH_hs_0006905

TC13000569.hg

g5174518_3p_a_at

Participates

as a member of

Phospho-R-SMAD1/5/9 [nucleoplasm] (Homo sapiens)

Other forms of this molecule

p-S465,S467-SMAD9 [cytosol]

SMAD9 [cytosol]

Inferred To

phospho-daf-14 [nucleoplasm] (Caenorhabditis elegans)

phospho-p-S465,S467-SMAD9 [nucleoplasm] (Caenorhabditis elegans)

phospho-p-S465,S467-SMAD9 [nucleoplasm] (Canis familiaris)

phospho-p-S465,S467-SMAD9 [nucleoplasm] (Drosophila melanogaster)

phospho-p-S465,S467-SMAD9 [nucleoplasm] (Mus musculus)

phospho-p-S465,S467-SMAD9 [nucleoplasm] (Rattus norvegicus)

phospho-sma8 [nucleoplasm] (Danio rerio)

phospho-SMAD9 [nucleoplasm] (Bos taurus)

phospho-SMAD9 [nucleoplasm] (Sus scrofa)

phospho-smad9 [nucleoplasm] (Xenopus tropicalis)

Homologues of p-S465,S467-SMAD9 [nucleoplasm] (Caenorhabditis elegans)

Modified Residues

Name

O-phospho-L-serine at 465

Coordinate

465

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 467

Coordinate

467

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_001120689.1, NP_005896.1

OpenTargets

ENSG00000120693

GeneCards

O15198

HPA

ENSG00000120693-SMAD9

Ensembl

ENST00000350148, ENST00000379826, ENSG00000120693, ENSP00000369154, ENSP00000239885

PRO

O15198

Pharos - Targets

O15198

Orphanet

18370

PDB

6FZT

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13485 SMAD4	20	SMAD4 P356R [cytosol] (R-HSA-3310988) SMAD4 K428T [cytosol] (R-HSA-3311004) SMAD4 D351del [cytosol] (R-HSA-3310974) SMAD4 R361H [cytosol] (R-HSA-3310984) SMAD4 P356L [cytosol] (R-HSA-3310987) SMAD4 A406T [cytosol] (R-HSA-3311003) SMAD4 D351Y [cytosol] (R-HSA-3310970) SMAD4 D351H [cytosol] (R-HSA-3310965) SMAD4 R361C [cytosol] (R-HSA-3310983) SMAD4 D351G [cytosol] (R-HSA-3310967) SMAD4 R515T [cytosol] (R-HSA-3311008) SMAD4 G352* [cytosol] (R-HSA-9678445) SMAD4 S178* [cytosol] (R-HSA-9675630) SMAD4 G477* [cytosol] (R-HSA-9678447) SMAD4 G473* [cytosol] (R-HSA-9678440) SMAD4 S144* [cytosol] (R-HSA-9675625) SMAD4 E538* [cytosol] (R-HSA-9675626) SMAD4 E390* [cytosol] (R-HSA-9675620) SMAD4 S154* [cytosol] (R-HSA-9675621) SMAD4 E330* [cytosol] (R-HSA-9675622)	0.748	4
UniProt:O60341 KDM1A	1	KDM1A [nucleoplasm] (R-HSA-996769)	0.508	2
UniProt:Q96LA8 PRMT6	1	PRMT6 [nucleoplasm] (R-HSA-5226884)	0.508	2