Reactome | p-S465,S467-SMAD9 [nucleoplasm]

p-S465,S467-SMAD9 [nucleoplasm]

Stable Identifier

R-HSA-201474

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Phospho-R-SMAD9, Mothers against decapentaplegic homolog 9, SMA9_HUMAN

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Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O15198 SMAD9

Gene Names

SMAD9, MADH6, MADH9, SMAD8

Chain

chain:1-467

Reference Genes

BioGPS Gene:4093 SMAD9

COSMIC (genes):SMAD9 SMAD9

CTD Gene:4093 SMAD9

dbSNP Gene:4093 SMAD9

ENSEMBL:ENSG00000120693 SMAD9

HGNC:6774 SMAD9

KEGG Gene (Homo sapiens):4093 SMAD9

Monarch:4093 SMAD9

NCBI Gene:4093 SMAD9

OMIM:603295 SMAD9

UCSC:O15198 SMAD9

Reference Transcript

Other Identifiers

0001450025

11740220_a_at

16778155

206320_s_at

227719_at

32986_s_at

3509839

3509841

3509843

3509844

3509846

3509849

3509850

3509851

3509853

3509854

3509856

3509857

3509864

4093

49904_at

50572_at

7971015

84856_at

84925_at

92002_at

A_23_P2814

A_24_P655849

GE474588

GO:0000228

GO:0000790

GO:0000981

GO:0003674

GO:0003677

GO:0003700

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005667

GO:0005694

GO:0005737

GO:0005829

GO:0006355

GO:0007165

GO:0007179

GO:0008150

GO:0009058

GO:0030509

GO:0030618

GO:0032991

GO:0034641

GO:0043167

GO:0043226

GO:0046872

GO:0060395

GO:0071141

GO:0071773

GO:1901522

Hs.103262.0.S1_3p_at

ILMN_1815385

PH_hs_0006905

TC13000569.hg

g5174518_3p_a_at

Participant Of

hasMember

Phospho-R-SMAD1/5/9 [nucleoplasm]

Other forms of this molecule

SMAD9 [cytosol]

p-S465,S467-SMAD9 [cytosol]

Inferred To

phospho-daf-14 [nucleoplasm] (Caenorhabditis elegans)

phospho-sma-2 [nucleoplasm] (Caenorhabditis elegans)

phospho-Smad9 [nucleoplasm] (Mus musculus)

phospho-Smad9 [nucleoplasm] (Rattus norvegicus)

phospho-sma-3 [nucleoplasm] (Caenorhabditis elegans)

phospho-SMAD9 [nucleoplasm] (Canis familiaris)

phospho-smad9 [nucleoplasm] (Sus scrofa)

phospho-smad9 [nucleoplasm] (Xenopus tropicalis)

Homologues of p-S465,S467-SMAD9 [nucleoplasm] (Caenorhabditis elegans)

phospho-Mad [nucleoplasm] (Drosophila melanogaster)

Modified Residues

Name

O-phospho-L-serine at 465

Coordinate

465

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 467

Coordinate

467

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_005896.1, NP_001120689.1

OpenTargets

ENSG00000120693

HPA

ENSG00000120693-SMAD9

GeneCards

O15198

Ensembl

ENST00000379826, ENSP00000369154, ENSP00000239885, ENSP00000382216, ENSG00000120693, ENST00000399275, ENST00000350148

PRO

O15198

Orphanet

18370

PDB

6FZT

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13485 SMAD4	88	SMAD4 K428T [cytosol] (R-HSA-3311004) SMAD4 P356R [cytosol] (R-HSA-3310988) SMAD4 D351del [cytosol] (R-HSA-3310974) SMAD4 R361H [cytosol] (R-HSA-3310984) SMAD4 P356L [cytosol] (R-HSA-3310987) SMAD4 A406T [cytosol] (R-HSA-3311003) SMAD4 D351Y [cytosol] (R-HSA-3310970) SMAD4 D351H [cytosol] (R-HSA-3310965) SMAD4 R361C [cytosol] (R-HSA-3310983) SMAD4 D351G [cytosol] (R-HSA-3310967) SMAD4 R515T [cytosol] (R-HSA-3311008) SMAD4 G352* [cytosol] (R-HSA-9678445) SMAD4 S178* [cytosol] (R-HSA-9675630) SMAD4 G477* [cytosol] (R-HSA-9678447) SMAD4 G473* [cytosol] (R-HSA-9678440) SMAD4 S144* [cytosol] (R-HSA-9675625) SMAD4 E538* [cytosol] (R-HSA-9675626) SMAD4 E390* [cytosol] (R-HSA-9675620) SMAD4 S154* [cytosol] (R-HSA-9675621) SMAD4 E330* [cytosol] (R-HSA-9675622) SMAD4 E417* [cytosol] (R-HSA-9675623) SMAD4 Y195* [cytosol] (R-HSA-9678462) SMAD4 E108* [cytosol] (R-HSA-9675640) SMAD4 S343* [cytosol] (R-HSA-9675641) SMAD4 E520* [cytosol] (R-HSA-9675636) SMAD4 G510* [cytosol] (R-HSA-9678452) SMAD4 G358* [cytosol] (R-HSA-9678453) SMAD4 E175* [cytosol] (R-HSA-9675637) SMAD4 E307* [cytosol] (R-HSA-9675639) SMAD4 E53* [cytosol] (R-HSA-9675633) SMAD4 S171* [cytosol] (R-HSA-9675634) SMAD4 G30* [cytosol] (R-HSA-9678450) SMAD4 G168* [cytosol] (R-HSA-9678451) SMAD4 Q366* [cytosol] (R-HSA-9675200) SMAD4 R135* [cytosol] (R-HSA-9675090) SMAD4 L146* [cytosol] (R-HSA-9678509) SMAD4 L440* [cytosol] (R-HSA-9678510) SMAD4 Q183* [cytosol] (R-HSA-9675176) SMAD4 Q289* [cytosol] (R-HSA-9675177) SMAD4 Q248* [cytosol] (R-HSA-9675178) SMAD4 Q249* [cytosol] (R-HSA-9675172) SMAD4 Q256* [cytosol] (R-HSA-9675173) SMAD4 Q239* [cytosol] (R-HSA-9675174) SMAD4 Q245* [cytosol] (R-HSA-9675175) SMAD4 Q224* [cytosol] (R-HSA-9675168) SMAD4 W509* [cytosol] (R-HSA-9678497) SMAD4 Q311* [cytosol] (R-HSA-9675169) SMAD4 W398* [cytosol] (R-HSA-9678498) SMAD4 Q250* [cytosol] (R-HSA-9675170) SMAD4 Q410* [cytosol] (R-HSA-9675196) SMAD4 Q534* [cytosol] (R-HSA-9675197) SMAD4 Q83* [cytosol] (R-HSA-9675199) SMAD4 Q448* [cytosol] (R-HSA-9675192) SMAD4 K428R [cytosol] (R-HSA-3311001) SMAD4 Q455* [cytosol] (R-HSA-9675193) SMAD4 R445* [cytosol] (R-HSA-9675065) SMAD4 Q442* [cytosol] (R-HSA-9675194) SMAD4 Q516* [cytosol] (R-HSA-9675195) SMAD4 C443* [cytosol] (R-HSA-9678523) SMAD4 Q334* [cytosol] (R-HSA-9675191) SMAD4 R361G [cytosol] (R-HSA-3310993) SMAD4 L172* [cytosol] (R-HSA-9678514) SMAD4 K122* [cytosol] (R-HSA-9678515) SMAD4 R361S [cytosol] (R-HSA-3310994) SMAD4 Y430* [cytosol] (R-HSA-9678476) SMAD4 Y260* [cytosol] (R-HSA-9678477) SMAD4 Y95* [cytosol] (R-HSA-9678478) SMAD4 Y322* [cytosol] (R-HSA-9678479) SMAD4 E321* [cytosol] (R-HSA-9675658) SMAD4 Y412* [cytosol] (R-HSA-9678469) SMAD4 R515* [cytosol] (R-HSA-3311012) SMAD4 Y328* [cytosol] (R-HSA-9678470) SMAD4 E33* [cytosol] (R-HSA-9675654) SMAD4 Y513* [cytosol] (R-HSA-9678471) SMAD4 E526* [cytosol] (R-HSA-9675648) SMAD4 S138* [cytosol] (R-HSA-9675649) SMAD4 Y276* [cytosol] (R-HSA-9678466) SMAD4 E205* [cytosol] (R-HSA-9675650) SMAD4 E49* [cytosol] (R-HSA-9675651) SMAD4 W101* [cytosol] (R-HSA-9678492) SMAD4 W268* [cytosol] (R-HSA-9678494) SMAD4 [nucleoplasm] (R-HSA-177103) SMAD4 [cytosol] (R-HSA-170862) RibC-SMAD4 [nucleoplasm] (R-HSA-2187323) SMAD4 W524* [cytosol] (R-HSA-9678491) SMAD4 W302* [cytosol] (R-HSA-9678490) SMAD4 S242* [cytosol] (R-HSA-9675167) SMAD4 Q116* [cytosol] (R-HSA-9675166)	0.748	4
UniProt:O60341 KDM1A	1	KDM1A [nucleoplasm] (R-HSA-996769)	0.508	2
UniProt:Q96LA8 PRMT6	1	PRMT6 [nucleoplasm] (R-HSA-5226884)	0.508	2

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