Reactome: A Curated Pathway Database

I-Smad competes with R-Smad1/5/8 for type I receptor

Stable Identifier
R-HSA-201475
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

I-SMADs reside in the nucleus presumably to be sequestered from the BMP2:receptor complex and thus avoid inappropriate silencing of the signalling pathway. Upon activation of the signalling pathway, I-SMADs exit the nucleus and are recruited to the signalling BMP2:receptor complex. I-SMADs directly bind to the so-called L45 loop of the type I receptor, the site of binding of R-SMADs. Thus, I-SMADs competitively inhibit the activation/phosphorylation of R-SMADs.

Literature References
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Orthologous Events