I-Smad competes with R-Smad1/5/8 for type I receptor

Stable Identifier
R-HSA-201475
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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I-SMADs reside in the nucleus presumably to be sequestered from the BMP2:receptor complex and thus avoid inappropriate silencing of the signalling pathway. Upon activation of the signalling pathway, I-SMADs exit the nucleus and are recruited to the signalling BMP2:receptor complex. I-SMADs directly bind to the so-called L45 loop of the type I receptor, the site of binding of R-SMADs. Thus, I-SMADs competitively inhibit the activation/phosphorylation of R-SMADs.

Literature References
PubMed ID Title Journal Year
12519765 Chromosomal region maintenance 1 (CRM1)-dependent nuclear export of Smad ubiquitin regulatory factor 1 (Smurf1) is essential for negative regulation of transforming growth factor-beta signaling by Smad7

Tajima, Y, Goto, K, Yoshida, M, Shinomiya, K, Sekimoto, T, Yoneda, Y, Miyazono, K, Imamura, T

J Biol Chem 2003
12857866 Cooperative inhibition of bone morphogenetic protein signaling by Smurf1 and inhibitory Smads

Murakami, G, Watabe, T, Takaoka, K, Miyazono, K, Imamura, T

Mol Biol Cell 2003
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Orthologous Events
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