Reactome | I-Smad competes with R-Smad1/5/8 for type I receptor

I-Smad competes with R-Smad1/5/8 for type I receptor

Stable Identifier

R-HSA-201475

Type

Reaction

Species

Homo sapiens

Compartment

extracellular region, plasma membrane, cytosol

Locations in the PathwayBrowser

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Summation

I-SMADs reside in the nucleus presumably to be sequestered from the BMP2:receptor complex and thus avoid inappropriate silencing of the signalling pathway. Upon activation of the signalling pathway, I-SMADs exit the nucleus and are recruited to the signalling BMP2:receptor complex. I-SMADs directly bind to the so-called L45 loop of the type I receptor, the site of binding of R-SMADs. Thus, I-SMADs competitively inhibit the activation/phosphorylation of R-SMADs.

Literature References

12519765	Chromosomal region maintenance 1 (CRM1)-dependent nuclear export of Smad ubiquitin regulatory factor 1 (Smurf1) is essential for negative regulation of transforming growth factor-beta signaling by Smad7	J Biol Chem	2003
12857866	Cooperative inhibition of bone morphogenetic protein signaling by Smurf1 and inhibitory Smads	Mol Biol Cell	2003

Participants

input

output

BMP2:BMP type II receptor:Phospho-BMP type I receptor:I-SMAD [plasma membrane] (Homo sapiens)

Participant Of

hasEvent

Signaling by BMP

Orthologous Events