Activated type I receptor phosphorylates R-Smad1/5/8 directly

Stable Identifier
R-HSA-201476
Type
Reaction
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
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Summation

Activated type I receptor kinase directly phosphorylates two of the C-terminal serine residues of SMAD2 or SMAD3. Binding of these R-SMADs to the L45 loop of the type I receptor is critical for this event.

Literature References
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
transmembrane receptor protein serine/threonine kinase activity of BMP:BMPRII:p-4S-BMPRI [plasma membrane]
Physical Entity
BMP:BMPRII:p-4S-BMPRI [plasma membrane]
Activity
transmembrane receptor protein serine/threonine kinase activity (0004675)
Orthologous Events
Activated type I receptor phosphorylates R-Smad1/5/8 directly (Bos taurus)
Activated type I receptor phosphorylates R-Smad1/5/8 directly (Canis familiaris)
Activated type I receptor phosphorylates R-Smad1/5/8 directly (Danio rerio)
Activated type I receptor phosphorylates R-Smad1/5/8 directly (Drosophila melanogaster)
Activated type I receptor phosphorylates R-Smad1/5/8 directly (Gallus gallus)
Activated type I receptor phosphorylates R-Smad1/5/8 directly (Mus musculus)
Activated type I receptor phosphorylates R-Smad1/5/8 directly (Rattus norvegicus)
Activated type I receptor phosphorylates R-Smad1/5/8 directly (Sus scrofa)
Activated type I receptor phosphorylates R-Smad1/5/8 directly (Taeniopygia guttata)
Activated type I receptor phosphorylates R-Smad1/5/8 directly (Xenopus tropicalis)
Authored
Huminiecki, L, Moustakas, A, 2007-11-07 10:22:00 Huminiecki, L, Moustakas, A, 2007-11-07 10:22:00
Reviewed
Heldin, CH, 2007-11-12