Activated type I receptor phosphorylates R-Smad1/5/8 directly

Stable Identifier
R-HSA-201476
Type
Reaction
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
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Summation

Activated type I receptor kinase directly phosphorylates two of the C-terminal serine residues of SMAD2 or SMAD3. Binding of these R-SMADs to the L45 loop of the type I receptor is critical for this event.

Literature References
PubMed ID Title Journal Year
9136927 The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase

Kretzschmar, M, Liu, F, Hata, A, Doody, J, Massague, J

Genes Dev 1997
8653785 MADR1, a MAD-related protein that functions in BMP2 signaling pathways

Hoodless, PA, Haerry, T, Abdollah, S, Stapleton, M, O'Connor, MB, Attisano, L, Wrana, JL

Cell 1996
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
transmembrane receptor protein serine/threonine kinase activity of BMP:BMPRII:p-4S-BMPRI [plasma membrane]
Physical Entity
BMP:BMPRII:p-4S-BMPRI [plasma membrane]
Activity
transmembrane receptor protein serine/threonine kinase activity (0004675)
Orthologous Events
Activated type I receptor phosphorylates R-Smad1/5/8 directly (Bos taurus)
Activated type I receptor phosphorylates R-Smad1/5/8 directly (Canis familiaris)
Activated type I receptor phosphorylates R-Smad1/5/8 directly (Danio rerio)
Activated type I receptor phosphorylates R-Smad1/5/8 directly (Drosophila melanogaster)
Activated type I receptor phosphorylates R-Smad1/5/8 directly (Gallus gallus)
Activated type I receptor phosphorylates R-Smad1/5/8 directly (Mus musculus)
Activated type I receptor phosphorylates R-Smad1/5/8 directly (Rattus norvegicus)
Activated type I receptor phosphorylates R-Smad1/5/8 directly (Sus scrofa)
Activated type I receptor phosphorylates R-Smad1/5/8 directly (Taeniopygia guttata)
Activated type I receptor phosphorylates R-Smad1/5/8 directly (Xenopus tropicalis)
Authored
Huminiecki, L  (2007-11-07)
Moustakas, A  (2007-11-07)
Reviewed
Heldin, CH  (2007-11-12)