Reactome: A Curated Pathway Database

Activated type I receptor phosphorylates R-Smad1/5/8 directly

Stable Identifier
R-HSA-201476
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Activated type I receptor kinase directly phosphorylates two of the C-terminal serine residues of SMAD2 or SMAD3. Binding of these R-SMADs to the L45 loop of the type I receptor is critical for this event.

Literature References
Participants
Participant Of
hasEvent
This entity is regulated by:
Title Physical Entity Activity
transmembrane receptor protein serine/threonine kinase activity of BMP:BMPRII:p-4S-BMPRI [plasma membrane] BMP:BMPRII:p-4S-BMPRI [plasma membrane] transmembrane receptor protein serine/threonine kinase activity (0004675)
Orthologous Events