Reactome | EMD [nuclear envelope]

EMD [nuclear envelope]

Stable Identifier

R-HSA-201573

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nuclear envelope

Synonyms

Emerin, EDMD, STA

Locations in the PathwayBrowser

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Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - M Phase (Homo sapiens)
    - Mitotic Metaphase and Anaphase (Homo sapiens)
      - Mitotic Anaphase (Homo sapiens)
        
        Nuclear Envelope Reassembly (Homo sapiens)
        
        Initiation of Nuclear Envelope Reformation (Homo sapiens)
        
        BANF1 binds chromatin, EMD/TMPO/LEMD3/LEMD2 and lamins (Homo sapiens)
        
        EMD/ TMPO/ LEMD3/ LEMD2 [nuclear envelope] (Homo sapiens)
        
        EMD [nuclear envelope] (Homo sapiens)
        
        EMD/TMPO/LEMD3/LEMD2:Lamin filaments:BANF1:Chromatin [nuclear envelope] (Homo sapiens)
        
        EMD/ TMPO/ LEMD3/ LEMD2 [nuclear envelope] (Homo sapiens)
        
        EMD [nuclear envelope] (Homo sapiens)
    - Mitotic Prophase (Homo sapiens)
      - Nuclear Envelope Breakdown (Homo sapiens)
        
        Depolymerisation of the Nuclear Lamina (Homo sapiens)
        
        Depolymerization of lamin filaments after PKC-mediated phosphorylation (Homo sapiens)
        
        EMD/ TMPO/ LEMD3/ LEMD2 [nuclear envelope] (Homo sapiens)
        
        EMD [nuclear envelope] (Homo sapiens)
        
        EMD/TMPO/LEMD3/LEMD2:Lamin filaments [nuclear envelope] (Homo sapiens)
        
        EMD/ TMPO/ LEMD3/ LEMD2 [nuclear envelope] (Homo sapiens)
        
        EMD [nuclear envelope] (Homo sapiens)
        
        VRK1/VRK2 phosphorylate BANF1 (Homo sapiens)
        
        EMD/TMPO/LEMD3/LEMD2:Lamin filaments [nuclear envelope] (Homo sapiens)
        
        EMD/ TMPO/ LEMD3/ LEMD2 [nuclear envelope] (Homo sapiens)
        
        EMD [nuclear envelope] (Homo sapiens)
        
        EMD/TMPO/LEMD3/LEMD2:Lamin filaments:BANF1:Chromatin [nuclear envelope] (Homo sapiens)
        
        EMD/ TMPO/ LEMD3/ LEMD2 [nuclear envelope] (Homo sapiens)
        
        EMD [nuclear envelope] (Homo sapiens)

External Reference Information

External Reference

UniProt:P50402 EMD

Gene Names

EMD, EDMD, STA

Chain

chain:1-254

Reference Genes

BioGPS Gene:2010 EMD

COSMIC (genes):EMD EMD

CTD Gene:2010 EMD

dbSNP Gene:2010 EMD

ENSEMBL:ENSG00000102119 EMD

HGNC:3331 EMD

KEGG Gene (Homo sapiens):2010 EMD

Monarch:2010 EMD

NCBI Gene:2010 EMD

OMIM:300384 EMD

UCSC:P50402 EMD

Reference Transcript

RefSeq:NM_000117.2 EMD

Other Identifiers

0004230397

11718429_at

1545

17108290

1JEI

2010

2029

209477_at

2ODC

2ODG

35239_at

3996290

3996291

3996292

3996294

3996295

3996297

3996298

3996301

3996303

3996304

3996305

609

62552

6GHD

8170850

A_14_P101353

A_23_P85171

AAA92645

AAH00738

AAP36065

BAA10972

BC000738

BT007401

BX936346

CAA57817

CAA60500

CAB001545

CAB002029

CAB062552

CAG38773

CCDS14745

CH471172

CR536536

D64111

EAW72742

EMD

EMD-202

ENSG00000102119

ENSP00000358857

ENST00000369842

ENST00000369842.8

EntrezGene:2010

EntrezGene:EMD

F8WEQ1

g12653890_3p_at

GE79714

GO:0000278

GO:0003674

GO:0003779

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005635

GO:0005637

GO:0005640

GO:0005654

GO:0005737

GO:0005783

GO:0005815

GO:0005819

GO:0005856

GO:0005874

GO:0006810

GO:0006913

GO:0006936

GO:0007049

GO:0007084

GO:0007165

GO:0007267

GO:0007517

GO:0008092

GO:0008150

GO:0008283

GO:0015031

GO:0016020

GO:0016021

GO:0030154

GO:0031616

GO:0031965

GO:0032541

GO:0035914

GO:0043226

GO:0045296

GO:0046827

GO:0048147

GO:0048487

GO:0048856

GO:0060828

GO:0061024

GO:0071363

GO:0090090

HGNC:3331

HPA000609

ILMN_1801421

IPR003887

IPR011015

IPR034989

IPR035004

L44140

LRG_745

LRG_745t1

MIM:300384

MIM:310300

NM_000117

NP_000108

PF03020

Q5HY57

SM00540

TC0X000768.hg

UPI0000129EA0

X82434

X82434_at

X86810

Participant Of

hasMember

EMD/ TMPO/ LEMD3/ LEMD2 [nuclear envelope]

Other forms of this molecule

EMD [endoplasmic reticulum membrane]

EMD [cytosol]

Inferred To

EMD [nuclear envelope] (Bos taurus)

EMD [nuclear envelope] (Canis familiaris)

EMD [nuclear envelope] (Mus musculus)

EMD [nuclear envelope] (Rattus norvegicus)

EMD [nuclear envelope] (Sus scrofa)

EMD [nuclear envelope] (Xenopus tropicalis)

Cross References

RefSeq

NP_000108.1

OpenTargets

ENSG00000102119

GeneCards

P50402

PRO

P50402

Orphanet

15973

PDB

1JEI, 2ODG, 6GHD, 2ODC

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O75531 BANF1	4	BANF1 [cytosol] (R-HSA-175371) p-T2,T3,S4-BANF1 [cytosol] (R-HSA-2995375) p-T2,T3,S4-BANF1 [nucleoplasm] (R-HSA-2993896) BANF1 [nucleoplasm] (R-HSA-175030)	0.863	10
UniProt:P02545 LMNA	3	LMNA-RAF1 fusion [cytosol] (R-HSA-6802399) p-LMNA-RAF1 fusion [cytosol] (R-HSA-6802537) LMNA(1-664) [nucleoplasm] (R-HSA-535479)	0.642	4
UniProt:Q9UH99 SUN2	1	SUN2 [nuclear envelope] (R-HSA-912382)	0.641	4
UniProt:P35222 CTNNB1	33	CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) pT41,S45-CTNNB1 S37A [cytosol] (R-HSA-4839619) pT41,S45-CTNNB1 S37Y [cytosol] (R-HSA-9663978) pT41,S45-CTNNB1 S37C [cytosol] (R-HSA-4839617) pS37,T41,S45-CTNNB1 S33A [cytosol] (R-HSA-9663976) pS37,T41,S45-CTNNB1 S33T [cytosol] (R-HSA-9663977) pS37,T41,S45-CTNNB1 S33C [cytosol] (R-HSA-4839630) pS37,T41,S45-CTNNB1 S33F [cytosol] (R-HSA-4839628) pS37,T41,S45-CTNNB1 S33P [cytosol] (R-HSA-4839626) pS37,T41,S45-CTNNB1 S33Y [cytosol] (R-HSA-4839625) pS45-CTNNB1 T41N [cytosol] (R-HSA-9663980) pS45-CTNNB1 T41A [cytosol] (R-HSA-4836868) pS45-CTNNB1 T41I [cytosol] (R-HSA-4839612) Ub-K,p-Y-CTNNB1 [cytosol] (R-HSA-8877006) p-Y-CTNNB1 [cytosol] (R-HSA-8876940) CTNNB1(116-376) [cytosol] (R-HSA-202950) CTNNB1(1-115) [cytosol] (R-HSA-202930) p-S552-CTNNB1 [nucleoplasm] (R-HSA-3134926) p-S552-CTNNB1 [cytosol] (R-HSA-3134933) CTNNB1 [plasma membrane] (R-HSA-9038440) p-S45 CTNNB1 [cytosol] (R-HSA-8942363) p-T41,S45 CTNNB1 [cytosol] (R-HSA-8942367) p-S37,T41,S45, CTNNB1 [cytosol] (R-HSA-8942369) p-S33,S37,T41,S45 CTNNB1 [cytosol] (R-HSA-8942374) CTNNB1 [cytosol] (R-HSA-448839) CTNNB1 [nucleoplasm] (R-HSA-3451168)	0.591	3
UniProt:Q12846 STX4	4	STX4 [plasma membrane] (R-HSA-181519) STX4 [phagocytic vesicle membrane] (R-HSA-2029044) STX4 [cytosol] (R-HSA-114505) p-STX4 [cytosol] (R-HSA-114681)	0.556	3
UniProt:Q13895 BYSL	2	BYSL [cytosol] (R-HSA-6791518) BYSL [nucleoplasm] (R-HSA-6791526)	0.556	3
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.527	3
UniProt:P60709 ACTB	5	ACTB(1-375) [cytosol] (R-HSA-201861) ACTB(1-375) [plasma membrane] (R-HSA-196016) ACTB(1-375) [nucleoplasm] (R-HSA-3321990) Unfolded ACTB [cytosol] (R-HSA-390462) ACTB(1-375) [lysosomal membrane] (R-HSA-196160)	0.524	2
UniProt:Q9D666 Sun1	1	Sun1 [nuclear envelope] (R-MMU-912375)	0.524	4
UniProt:Q99962 SH3GL2	4	SH3GL2 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130629) SH3GL2 [Golgi membrane] (R-HSA-351189) SH3GL2 [plasma membrane] (R-HSA-177495) SH3GL2 [cytosol] (R-HSA-182958)	0.508	2
UniProt:Q16623 STX1A	6	STX1A [plasma membrane] (R-HSA-6794231) STX1A [plasma membrane] (R-HSA-449128) STX1A(?-288) [plasma membrane] (R-HSA-5246518) STX1A(1-?) [cytosol] (R-HSA-3065964) STX1A [cytosol] (R-HSA-9609866) STX1A [endoplasmic reticulum membrane] (R-HSA-9609878)	0.488	2
UniProt:P21964 COMT	2	COMT [plasma membrane] (R-HSA-379386) COMT [cytosol] (R-HSA-175974)	0.488	2
UniProt:Q8N4V1 MMGT1	1	MMGT1 [Golgi membrane] (R-HSA-5216137)	0.488	2
UniProt:Q9HAQ2 KIF9	1	KIF9 [cytosol] (R-HSA-984616)	0.488	2
UniProt:Q13190 STX5	5	STX5 [endoplasmic reticulum membrane] (R-HSA-5689474) STX5 [ER to Golgi transport vesicle membrane] (R-HSA-5689838) STX5 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688157) STX5 [Golgi membrane] (R-HSA-6807771) STX5 [cytosol] (R-HSA-9613991)	0.488	2
UniProt:O94901 SUN1	1	SUN1 [nuclear envelope] (R-HSA-912371)	0.463	2