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EMD [nuclear envelope]
Stable Identifier
R-HSA-201573
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nuclear envelope
Synonyms
Emerin, EDMD, STA
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
M Phase (Homo sapiens)
Mitotic Metaphase and Anaphase (Homo sapiens)
Mitotic Anaphase (Homo sapiens)
Nuclear Envelope (NE) Reassembly (Homo sapiens)
Initiation of Nuclear Envelope (NE) Reformation (Homo sapiens)
BANF1 binds chromatin, EMD/TMPO/LEMD3/LEMD2 and lamins (Homo sapiens)
EMD/ TMPO/ LEMD3/ LEMD2 [nuclear envelope] (Homo sapiens)
EMD [nuclear envelope] (Homo sapiens)
EMD/TMPO/LEMD3/LEMD2:Lamin filaments:BANF1:Chromatin [nuclear envelope] (Homo sapiens)
EMD/ TMPO/ LEMD3/ LEMD2 [nuclear envelope] (Homo sapiens)
EMD [nuclear envelope] (Homo sapiens)
Mitotic Prophase (Homo sapiens)
Nuclear Envelope Breakdown (Homo sapiens)
Depolymerisation of the Nuclear Lamina (Homo sapiens)
Depolymerization of lamin filaments after PKC-mediated phosphorylation (Homo sapiens)
EMD/ TMPO/ LEMD3/ LEMD2 [nuclear envelope] (Homo sapiens)
EMD [nuclear envelope] (Homo sapiens)
EMD/TMPO/LEMD3/LEMD2:Lamin filaments [nuclear envelope] (Homo sapiens)
EMD/ TMPO/ LEMD3/ LEMD2 [nuclear envelope] (Homo sapiens)
EMD [nuclear envelope] (Homo sapiens)
VRK1/VRK2 phosphorylate BANF1 (Homo sapiens)
EMD/TMPO/LEMD3/LEMD2:Lamin filaments [nuclear envelope] (Homo sapiens)
EMD/ TMPO/ LEMD3/ LEMD2 [nuclear envelope] (Homo sapiens)
EMD [nuclear envelope] (Homo sapiens)
EMD/TMPO/LEMD3/LEMD2:Lamin filaments:BANF1:Chromatin [nuclear envelope] (Homo sapiens)
EMD/ TMPO/ LEMD3/ LEMD2 [nuclear envelope] (Homo sapiens)
EMD [nuclear envelope] (Homo sapiens)
External Reference Information
External Reference
UniProt:P50402 EMD
Gene Names
EMD, EDMD, STA
Chain
chain:1-254
Reference Genes
BioGPS Gene:2010 EMD
COSMIC (genes):EMD EMD
CTD Gene:2010 EMD
dbSNP Gene:2010 EMD
ENSEMBL:ENSG00000102119 EMD
HGNC:3331 EMD
KEGG Gene (Homo sapiens):2010 EMD
Monarch:2010 EMD
NCBI Gene:2010 EMD
OMIM:300384 EMD
UCSC:P50402 EMD
Reference Transcript
RefSeq:NM_000117.2 EMD
Other Identifiers
0004230397
11718429_at
17108290
2010
209477_at
35239_at
3996290
3996291
3996292
3996294
3996295
3996297
3996298
3996301
3996303
3996304
3996305
8170850
A_14_P101353
A_23_P85171
GE79714
GO:0000278
GO:0003674
GO:0003779
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005635
GO:0005637
GO:0005640
GO:0005654
GO:0005737
GO:0005783
GO:0005815
GO:0005819
GO:0005856
GO:0005874
GO:0006810
GO:0006913
GO:0006936
GO:0007049
GO:0007084
GO:0007165
GO:0007267
GO:0007517
GO:0008092
GO:0008150
GO:0008283
GO:0015031
GO:0016020
GO:0016021
GO:0030154
GO:0031616
GO:0031965
GO:0032541
GO:0035914
GO:0043226
GO:0045296
GO:0046827
GO:0048147
GO:0048487
GO:0048856
GO:0060828
GO:0061024
GO:0071363
GO:0090090
ILMN_1801421
TC0X000768.hg
X82434_at
g12653890_3p_at
Participant Of
hasMember
EMD/ TMPO/ LEMD3/ LEMD2 [nuclear envelope]
Other forms of this molecule
EMD [endoplasmic reticulum membrane]
EMD [cytosol]
Inferred To
EMD [nuclear envelope] (Bos taurus)
EMD [nuclear envelope] (Canis familiaris)
EMD [nuclear envelope] (Sus scrofa)
EMD [nuclear envelope] (Xenopus tropicalis)
Emd [nuclear envelope] (Mus musculus)
Emd [nuclear envelope] (Rattus norvegicus)
Cross References
RefSeq
NP_000108.1
OpenTargets
ENSG00000102119
HPA
ENSG00000102119-EMD
GeneCards
P50402
Ensembl
ENST00000369842
,
ENSP00000358857
,
ENSG00000102119
PRO
P50402
Orphanet
15973
PDB
2ODC
,
6GHD
,
6RPR
,
2ODG
,
1JEI
Interactors (18)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O75531 BANF1
4
BANF1 [nucleoplasm]
(R-HSA-175030)
p-T2,T3,S4-BANF1 [nucleoplasm]
(R-HSA-2993896)
p-T2,T3,S4-BANF1 [cytosol]
(R-HSA-2995375)
BANF1 [cytosol]
(R-HSA-175371)
0.908
12
UniProt:Q13895 BYSL
2
BYSL [cytosol]
(R-HSA-6791518)
BYSL [nucleoplasm]
(R-HSA-6791526)
0.718
6
UniProt:P02545 LMNA
3
LMNA-RAF1 fusion [cytosol]
(R-HSA-6802399)
LMNA(1-664) [nucleoplasm]
(R-HSA-535479)
p-LMNA-RAF1 fusion [cytosol]
(R-HSA-6802537)
0.642
4
UniProt:Q9UH99 SUN2
1
SUN2 [nuclear envelope]
(R-HSA-912382)
0.641
4
UniProt:P35222 CTNNB1
33
CTNNB1 S45F [cytosol]
(R-HSA-4791268)
CTNNB1 S45A [cytosol]
(R-HSA-9663982)
CTNNB1 S45C [cytosol]
(R-HSA-9663983)
CTNNB1 S45Y [cytosol]
(R-HSA-9663975)
CTNNB1 S45N [cytosol]
(R-HSA-9663984)
CTNNB1 S45P [cytosol]
(R-HSA-4791272)
pT41,S45-CTNNB1 S37P [cytosol]
(R-HSA-9663981)
pT41,S45-CTNNB1 S37F [cytosol]
(R-HSA-4839621)
pT41,S45-CTNNB1 S37A [cytosol]
(R-HSA-4839619)
pT41,S45-CTNNB1 S37Y [cytosol]
(R-HSA-9663978)
pT41,S45-CTNNB1 S37C [cytosol]
(R-HSA-4839617)
pS37,T41,S45-CTNNB1 S33A [cytosol]
(R-HSA-9663976)
pS37,T41,S45-CTNNB1 S33T [cytosol]
(R-HSA-9663977)
pS37,T41,S45-CTNNB1 S33C [cytosol]
(R-HSA-4839630)
pS37,T41,S45-CTNNB1 S33F [cytosol]
(R-HSA-4839628)
pS37,T41,S45-CTNNB1 S33P [cytosol]
(R-HSA-4839626)
pS37,T41,S45-CTNNB1 S33Y [cytosol]
(R-HSA-4839625)
pS45-CTNNB1 T41N [cytosol]
(R-HSA-9663980)
pS45-CTNNB1 T41A [cytosol]
(R-HSA-4836868)
pS45-CTNNB1 T41I [cytosol]
(R-HSA-4839612)
Ub-K,p-Y-CTNNB1 [cytosol]
(R-HSA-8877006)
p-Y-CTNNB1 [cytosol]
(R-HSA-8876940)
p-S552-CTNNB1 [nucleoplasm]
(R-HSA-3134926)
p-S552-CTNNB1 [cytosol]
(R-HSA-3134933)
CTNNB1(116-376) [cytosol]
(R-HSA-202950)
CTNNB1(1-115) [cytosol]
(R-HSA-202930)
CTNNB1 [plasma membrane]
(R-HSA-9038440)
p-S45 CTNNB1 [cytosol]
(R-HSA-8942363)
p-T41,S45 CTNNB1 [cytosol]
(R-HSA-8942367)
p-S37,T41,S45, CTNNB1 [cytosol]
(R-HSA-8942369)
p-S33,S37,T41,S45 CTNNB1 [cytosol]
(R-HSA-8942374)
CTNNB1 [cytosol]
(R-HSA-448839)
CTNNB1 [nucleoplasm]
(R-HSA-3451168)
0.591
3
UniProt:P02545-1 LMNA
7
LMNA(231-664) [nuclear envelope]
(R-HSA-352249)
p-S22, S392-LMNA-1 [nucleoplasm]
(R-HSA-8868349)
LMNA(1-230) [nuclear envelope]
(R-HSA-352253)
p-S22, S395-LMNA-1 [nucleoplasm]
(R-HSA-5229021)
p-S395-LMNA-1 [nucleoplasm]
(R-HSA-5228743)
Lamin A [nucleoplasm]
(R-HSA-264866)
LMNA-1 [cytosol]
(R-HSA-2995371)
0.59
2
UniProt:Q9HAQ2 KIF9
1
KIF9 [cytosol]
(R-HSA-984616)
0.556
3
UniProt:Q12846 STX4
4
STX4 [phagocytic vesicle membrane]
(R-HSA-2029044)
STX4 [plasma membrane]
(R-HSA-181519)
STX4 [cytosol]
(R-HSA-114505)
p-STX4 [cytosol]
(R-HSA-114681)
0.556
3
UniProt:P21964 COMT
2
COMT [cytosol]
(R-HSA-175974)
COMT [plasma membrane]
(R-HSA-379386)
0.556
3
UniProt:Q16623 STX1A
6
STX1A [plasma membrane]
(R-HSA-6794231)
STX1A [plasma membrane]
(R-HSA-449128)
STX1A(?-288) [plasma membrane]
(R-HSA-5246518)
STX1A(1-?) [cytosol]
(R-HSA-3065964)
STX1A [cytosol]
(R-HSA-9609866)
STX1A [endoplasmic reticulum membrane]
(R-HSA-9609878)
0.556
3
UniProt:Q8N4V1 MMGT1
1
MMGT1 [Golgi membrane]
(R-HSA-5216137)
0.556
3
UniProt:P04049 RAF1
54
p-S338,Y340,Y341-RAF1 [cytosol]
(R-HSA-5624465)
RAF1 [cytosol]
(R-HSA-167205)
p-S338-RAF1 [cytosol]
(R-HSA-5624469)
p-S621-RAF1 S259F [cytosol]
(R-HSA-9656124)
p-S621-RAF1 S257L [cytosol]
(R-HSA-9656121)
p-S621-RAF1 P261L [cytosol]
(R-HSA-9656106)
p-S621-RAF1 N262K [cytosol]
(R-HSA-9656101)
p-S621-RAF1 P261A [cytosol]
(R-HSA-9656103)
p-S621-RAF1 P261S [cytosol]
(R-HSA-9656113)
p-S621-RAF1 S259T [cytosol]
(R-HSA-9656130)
p-S621-RAF1 P261T [cytosol]
(R-HSA-9656115)
p-S621-RAF1 P261R [cytosol]
(R-HSA-9656110)
p-S621-RAF1 S259P [cytosol]
(R-HSA-9656127)
p-S621-RAF1 T260I [cytosol]
(R-HSA-9656136)
p-S621-RAF1 T260R [cytosol]
(R-HSA-9656139)
p-S621-RAF1 V263A [cytosol]
(R-HSA-9656148)
p-S621-RAF1 R256S [cytosol]
(R-HSA-9656119)
p-S621-RAF1 T491I [cytosol]
(R-HSA-9656143)
p-S621-RAF1 D486N [cytosol]
(R-HSA-9656088)
p-S621-RAF1 S427G [cytosol]
(R-HSA-9656134)
p-S621-RAF1 L613V [cytosol]
(R-HSA-9656098)
p-S621-RAF1 G361A [cytosol]
(R-HSA-9656092)
p-S621-RAF1 G370R [cytosol]
(R-HSA-9656094)
p-S621-RAF1 D486G [cytosol]
(R-HSA-9656085)
p-S621-RAF1 T491R [cytosol]
(R-HSA-9656145)
p-S338,Y341,T492,S494,S621 RAF1 D486N [cytosol]
(R-HSA-9656026)
p-S338,Y341,T492,S494,S621 RAF1 S427G [cytosol]
(R-HSA-9656070)
p-S338,Y341,T492,S494,S621 RAF1 L613V [cytosol]
(R-HSA-9656035)
p-S338,Y341,S494,S621-RAF1 T491I [cytosol]
(R-HSA-9656019)
p-S338,Y341,T492,S494,S621 RAF1 G361A [cytosol]
(R-HSA-9656029)
p-S338,Y341,T492,S494,S621 RAF1 G370R [cytosol]
(R-HSA-9656031)
p-S338,Y341,T492,S494,S621 RAF1 D486G [cytosol]
(R-HSA-9656023)
p-S338,Y341,S494,S621 RAF1 T491R [cytosol]
(R-HSA-9656017)
p-S338,Y341,T492,S494,S621 RAF1 S259F [cytosol]
(R-HSA-9656062)
p-S338,Y341,T492,S494,S621 RAF1 P261A [cytosol]
(R-HSA-9656041)
p-S338,Y341,T492,S494,S621 RAF1 S257L [cytosol]
(R-HSA-9656058)
p-S338,Y341,T492,S494,S621 RAF1 P261L [cytosol]
(R-HSA-9656043)
p-S338,Y341,T492,S494,S621 RAF1 P261T [cytosol]
(R-HSA-9656053)
p-S338,Y341,T492,S494,S621 RAF1 N262K [cytosol]
(R-HSA-9656037)
p-S338,Y341,T492,S494,S621 RAF1 P261S [cytosol]
(R-HSA-9656050)
p-S338,Y341,T492,S494,S621 RAF1 S259T [cytosol]
(R-HSA-9656067)
p-S338,Y341,T492,S494,S621 RAF1 T260R [cytosol]
(R-HSA-9656077)
p-S338,Y341,T492,S494,S621 RAF1 P261R [cytosol]
(R-HSA-9656047)
p-S338,Y341,T492,S494,S621 RAF1 R256S [cytosol]
(R-HSA-9656056)
p-S338,Y341,T492,S494,S621 RAF1 T260I [cytosol]
(R-HSA-9656074)
p-S338,Y341,T492,S494,S621 RAF1 V263A [cytosol]
(R-HSA-9656080)
p-S338,Y341,T492,S494,S621 RAF1 S259P [cytosol]
(R-HSA-9656065)
hyperphosphorylated RAF1 [plasma membrane]
(R-HSA-5675193)
p-S621-RAF1 [plasma membrane]
(R-HSA-206222)
p-Y341,T491,S494,S621 RAF1 [plasma membrane]
(R-HSA-5675420)
p-S259,S621-RAF1 [cytosol]
(R-HSA-109786)
p-S621-RAF1 [cytosol]
(R-HSA-206028)
p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane]
(R-HSA-5672665)
p-S338,Y341,T491,S494,S621 RAF1 [cytosol]
(R-HSA-5672664)
0.527
2
UniProt:P19320 VCAM1
1
VCAM1 [plasma membrane]
(R-HSA-197834)
0.527
4
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.527
3
UniProt:P60709 ACTB
5
Unfolded ACTB [cytosol]
(R-HSA-390462)
ACTB(1-375) [lysosomal membrane]
(R-HSA-196160)
ACTB(1-375) [cytosol]
(R-HSA-201861)
ACTB(1-375) [nucleoplasm]
(R-HSA-3321990)
ACTB(1-375) [plasma membrane]
(R-HSA-196016)
0.524
2
UniProt:Q9D666 Sun1
1
Sun1 [nuclear envelope]
(R-MMU-912375)
0.524
4
UniProt:Q99962 SH3GL2
4
SH3GL2 [cytosol]
(R-HSA-182958)
SH3GL2 [plasma membrane]
(R-HSA-177495)
SH3GL2 [clathrin-coated endocytic vesicle membrane]
(R-HSA-2130629)
SH3GL2 [Golgi membrane]
(R-HSA-351189)
0.508
2
UniProt:O94901 SUN1
1
SUN1 [nuclear envelope]
(R-HSA-912371)
0.463
2
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