Reactome | PSEN1(1-467) [plasma membrane]

PSEN1(1-467) [plasma membrane]

Stable Identifier

R-HSA-201606

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

PSEN1, Presenilin-1 precursor

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P49768 PSEN1

Gene Names

PSEN1, AD3, PS1, PSNL1

Chain

chain:1-298, chain:299-467, chain:346-467

Reference Genes

BioGPS Gene:5663 PSEN1

COSMIC (genes):PSEN1 PSEN1

CTD Gene:5663 PSEN1

dbSNP Gene:5663 PSEN1

ENSEMBL:ENSG00000080815 PSEN1

HGNC:9508 PSEN1

KEGG:hsa:5663 PSEN1

Monarch:5663 PSEN1

NCBI Gene:5663 PSEN1

OMIM:104311 PSEN1

UCSC:P49768 PSEN1

Reference Transcript

Participates

as a member of

Azurophil granule membrane proteins [plasma membrane] (Homo sapiens)

Other forms of this molecule

PSEN1(299-467) [plasma membrane]

PSEN1(1-298) [plasma membrane]

PSEN1(1-298) [azurophil granule membrane]

PSEN1(1-467) [azurophil granule membrane]

PSEN1(299-467) [azurophil granule membrane]

Inferred To

psenA [plasma membrane] (Dictyostelium discoideum)

psen1 [plasma membrane] (Danio rerio)

psen1 [plasma membrane] (Xenopus tropicalis)

psenB [plasma membrane] (Dictyostelium discoideum)

PSEN1 [plasma membrane] (Bos taurus)

PSEN1 [plasma membrane] (Canis familiaris)

PSEN1 [plasma membrane] (Gallus gallus)

PSEN1 [plasma membrane] (Sus scrofa)

Psen1 [plasma membrane] (Mus musculus)

Psen1 [plasma membrane] (Rattus norvegicus)

Homologues of PSEN1(1-467) [plasma membrane] (Dictyostelium discoideum)

Cross References

RefSeq

XP_011535274.1, NP_000012.1, NP_015557.2, XP_011535275.1, XP_005267921.1, XP_011535276.1, XP_011535273.1, XP_005267923.1

Guide to Pharmacology - Targets

2402

OpenTargets

ENSG00000080815

ENSEMBL

ENST00000700265, ENST00000700321, ENSP00000452477, ENSP00000514908, ENSP00000451429, ENSP00000450551, ENST00000324501, ENSG00000080815, ENSP00000514904, ENST00000553599, ENST00000700436, ENST00000557511, ENST00000553855, ENSP00000452242, ENSP00000514951, ENSP00000326366, ENST00000700469, ENSP00000514940, ENST00000700324, ENST00000556951, ENST00000700273, ENSP00000514949, ENST00000700313, ENSP00000514944, ENSP00000514966, ENST00000700378, ENSP00000514903, ENSP00000514901, ENSP00000514968, ENST00000554131, ENST00000700322, ENST00000394157, ENST00000700389, ENSP00000514948, ENST00000700267, ENST00000700323, ENST00000555386, ENST00000700268, ENST00000394164, ENST00000357710, ENST00000700317, ENSP00000514970, ENSP00000377719, ENSP00000515002, ENSP00000514950, ENSP00000350342, ENSP00000451915, ENSP00000514933, ENST00000700269, ENSP00000450845, ENST00000700306, ENSP00000377712, ENST00000700375, ENSP00000514905, ENSP00000514987

ZINC - Substances

PSN1_HUMAN

ZINC target

P49768

PRO

P49768

PDB

8K8E, 5A63, 6LQG, 6LR4, 8KCP, 8KCO, 8KCT, 8X52, 8X54, 8KCS, 7Y5T, 8X53, 6IDF, 8OQY, 7D8X, 8OQZ, 8KCU, 5FN2, 5FN5, 5FN3, 5FN4, 8IM7, 4UIS, 7C9I, 6IYC, 2KR6

GeneCards

PSEN1

HPA

ENSG00000080815-PSEN1

Pharos - Targets

P49768

Orphanet

PSEN1

ZINC - Predictions - Purchasable

PSN1_HUMAN

HMDB Protein

HMDBP07957

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P05067-4 APP	2	APP [mitochondrial inner membrane] (R-HSA-9839060) APP (535-695) [cytosol] (R-HSA-9839084)	0.702	4
UniProt:Q02410 APBA1	1	APBA1 [cytosol] (R-HSA-5336459)	0.697	4
UniProt:P56817 BACE1	8	BACE1 [endosome membrane] (R-HSA-5692942) BACE1(46-501) [plasma membrane] (R-HSA-5692933) BACE1(46-501) [Golgi-associated vesicle lumen] (R-HSA-5693105) 7K-BACE1(46-501) [Golgi-associated vesicle lumen] (R-HSA-5693106) 7K-BACE1 [Golgi-associated vesicle lumen] (R-HSA-5693095) BACE1(22-45) [Golgi-associated vesicle lumen] (R-HSA-5693069) 7K-BACE1 [endoplasmic reticulum lumen] (R-HSA-5693006) BACE1 [endoplasmic reticulum lumen] (R-HSA-6783326)	0.639	6
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.632	6
UniProt:Q9NZC2 TREM2	1	TREM2 [plasma membrane] (R-HSA-197664)	0.599	5
UniProt:Q9BQ95 ECSIT	2	ECSIT [cytosol] (R-HSA-168064) ECSIT [mitochondrial inner membrane] (R-HSA-5689047)	0.582	4
UniProt:P12830 CDH1	8	CDH1(155-882) [plasma membrane] (R-HSA-198003) CDH1(751-882) [plasma membrane] (R-HSA-202929) CDH1(155-750) [plasma membrane] (R-HSA-202940) p-Y753,Y754-CDH1(155-882) [plasma membrane] (R-HSA-8876938) Ub-K,p-Y753,Y754-CDH1(155-882) [plasma membrane] (R-HSA-8877002) CDH1(701-882) [extracellular region] (R-HSA-2534158) CDH1(155-700) [plasma membrane] (R-HSA-2534244) CDH1(732-882) [plasma membrane] (R-HSA-3827997)	0.564	2
UniProt:O75369 FLNB	1	FLNB [cytosol] (R-HSA-354163)	0.508	2
UniProt:P21333 FLNA	3	FLNA [cytosol] (R-HSA-210019) p-S2152-FLNA [cytosol] (R-HSA-5669246) FLNA [extracellular region] (R-HSA-350712)	0.508	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	5
UniProt:Q15392 DHCR24	1	DHCR24 [endoplasmic reticulum membrane] (R-HSA-196414)	0.462	3
UniProt:P63208 SKP1	2	SKP1 [cytosol] (R-HSA-174150) SKP1 [nucleoplasm] (R-HSA-187538)	0.462	3