Caspase-mediated cleavage of Rock-1

Stable Identifier
R-HSA-201611
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Caspase-3-mediated cleavage of ROCK I induces MLC phosphorylation and apoptotic membrane blebbing (Sebbagh et al., 2001). Cleavage and activation of ROCK-1 by caspase-3 plays has also been shown to play a crucial role in in cardiac myocyte apoptosis (Chang et al., 2006).

Literature References
PubMed ID Title Journal Year
16983089 Activation of Rho-associated coiled-coil protein kinase 1 (ROCK-1) by caspase-3 cleavage plays an essential role in cardiac myocyte apoptosis

Chang, J, Xie, M, Shah, VR, Schneider, MD, Entman, ML, Wei, L, Schwartz, RJ

Proc Natl Acad Sci U S A 2006
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
cysteine-type endopeptidase activity of Caspase-3 [cytosol]
Physical Entity
Activity
Orthologous Events
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Reviewed
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