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ADD1 [cytosol]
Stable Identifier
R-HSA-201623
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Adducin alpha, Alpha adducin
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Unfolded Protein Response (UPR) (Homo sapiens)
IRE1alpha activates chaperones (Homo sapiens)
XBP1(S) activates chaperone genes (Homo sapiens)
Expression of ADD1 (Adducin alpha) (Homo sapiens)
ADD1 [cytosol] (Homo sapiens)
Programmed Cell Death (Homo sapiens)
Apoptosis (Homo sapiens)
Apoptotic execution phase (Homo sapiens)
Apoptotic cleavage of cellular proteins (Homo sapiens)
Caspase-mediated cleavage of cytoskeletal proteins (Homo sapiens)
Caspase-mediated cleavage of alpha adducin (Homo sapiens)
ADD1 [cytosol] (Homo sapiens)
Transport of small molecules (Homo sapiens)
Miscellaneous transport and binding events (Homo sapiens)
ADD1:ADD2 binds DMTN (Homo sapiens)
ADD1:ADD2 [cytosol] (Homo sapiens)
ADD1 [cytosol] (Homo sapiens)
ADD1:ADD2:DMTN [cytosol] (Homo sapiens)
ADD1:ADD2 [cytosol] (Homo sapiens)
ADD1 [cytosol] (Homo sapiens)
ADD1:ADD3 binds DMTN (Homo sapiens)
ADD1:ADD3 [cytosol] (Homo sapiens)
ADD1 [cytosol] (Homo sapiens)
ADD1:ADD3:DMTN [cytosol] (Homo sapiens)
ADD1:ADD3 [cytosol] (Homo sapiens)
ADD1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P35611 ADD1
Gene Names
ADD1, ADDA
Chain
chain:1-737
Reference Genes
BioGPS Gene:118 ADD1
COSMIC (genes):ADD1 ADD1
CTD Gene:118 ADD1
dbSNP Gene:118 ADD1
ENSEMBL:ENSG00000087274 ADD1
HGNC:243 ADD1
KEGG Gene (Homo sapiens):118 ADD1
Monarch:118 ADD1
NCBI Gene:118 ADD1
OMIM:102680 ADD1
UCSC:P35611 ADD1
Reference Transcript
RefSeq:XM_017007707.1 ADD1
RefSeq:NM_014189.3 ADD1
RefSeq:XM_017007710.1 ADD1
RefSeq:XM_005247937.2 ADD1
RefSeq:NM_014190.3 ADD1
RefSeq:XM_017007708.1 ADD1
RefSeq:NM_001119.4 ADD1
RefSeq:XM_017007704.1 ADD1
RefSeq:NM_176801.2 ADD1
RefSeq:XM_017007709.1 ADD1
RefSeq:XM_017007706.1 ADD1
RefSeq:NM_001286645.1 ADD1
Other Identifiers
0002690132
11716514_s_at
11716515_x_at
11716516_a_at
11716517_x_at
11747763_a_at
118
16964232
208030_s_at
214726_3p_x_at
214726_x_at
214736_s_at
2715633
2715635
2715636
2715647
2715648
2715651
2715652
2715660
2715661
2715663
2715666
2715668
2715680
2715681
2715682
2715683
2715687
2715689
2715691
2715700
2715703
2715706
2715711
2715712
2715713
2715714
2715715
2715716
2715717
2715719
32145_at
32146_s_at
8093643
A_14_P108022
A_14_P123088
A_23_P212768
A_24_P109272
GE80556
GO:0000902
GO:0001701
GO:0002376
GO:0003674
GO:0003723
GO:0003779
GO:0005198
GO:0005200
GO:0005516
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005856
GO:0005886
GO:0005912
GO:0005925
GO:0006810
GO:0006884
GO:0006950
GO:0007010
GO:0007165
GO:0008092
GO:0008134
GO:0008150
GO:0008290
GO:0009790
GO:0014069
GO:0016020
GO:0016604
GO:0020027
GO:0022607
GO:0030036
GO:0030154
GO:0030218
GO:0030507
GO:0032092
GO:0032991
GO:0034330
GO:0035264
GO:0036498
GO:0040007
GO:0042592
GO:0042803
GO:0043226
GO:0044853
GO:0045296
GO:0046982
GO:0048856
GO:0048873
GO:0051015
GO:0051016
GO:0051017
GO:0055085
GO:0065003
GO:0071277
GO:1903142
GO:1903393
Hs.183706.1.S1_3p_s_at
Hs.183706.2.S1_3p_s_at
ILMN_1759252
ILMN_2356786
L07261_s_at
PH_hs_0010830
TC04000039.hg
TC04001860.hg
Z68280_cds2_s_at
g7710113_3p_s_at
Participant Of
hasComponent
ADD1:ADD2 [cytosol]
ADD1:ADD3 [cytosol]
output
Expression of ADD1 (Adducin alpha)
input
Caspase-mediated cleavage of alpha adducin
Other forms of this molecule
ADD1(634-737) [cytosol]
ADD1(1-633) [cytosol]
Inferred To
hts [cytosol] (Drosophila melanogaster)
add1 [cytosol] (Danio rerio)
add1 [cytosol] (Xenopus tropicalis)
ADD1 [cytosol] (Canis familiaris)
ADD1 [cytosol] (Dictyostelium discoideum)
ADD1 [cytosol] (Gallus gallus)
ADD1 [cytosol] (Schizosaccharomyces pombe)
ADD1 [cytosol] (Sus scrofa)
add-2 [cytosol] (Caenorhabditis elegans)
Add1 [cytosol] (Mus musculus)
Add1 [cytosol] (Rattus norvegicus)
Cross References
RefSeq
NP_001273574.1
,
XP_016863198.1
,
NP_001110.2
,
NP_054909.2
,
XP_016863195.1
,
NP_789771.1
,
XP_005247994.1
,
XP_016863199.1
,
XP_016863196.1
,
XP_016863197.1
,
XP_016863193.1
,
NP_054908.2
OpenTargets
ENSG00000087274
HPA
ENSG00000087274-ADD1
GeneCards
P35611
Ensembl
ENSP00000381193
,
ENSP00000498269
,
ENST00000398123
,
ENSP00000348100
,
ENST00000651918
,
ENST00000398129
,
ENST00000398125
,
ENST00000355842
,
ENSG00000087274
,
ENSP00000381191
,
ENSP00000381197
,
ENST00000264758
,
ENSP00000264758
PRO
P35611
Orphanet
24329
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:A0A140G945 CRYA2
0.556
3
UniProt:Q13153 PAK1
6
p-S144-PAK1 [cytosol]
(R-HSA-451339)
Active PAK1 [cytosol]
(R-HSA-8964622)
PAK1 [plasma membrane]
(R-HSA-3928409)
p-S144,T423-PAK1 [plasma membrane]
(R-HSA-3928472)
PAK1 [cytosol]
(R-HSA-162629)
p-S144,T423-PAK1 [cytosol]
(R-HSA-399819)
0.556
3
UniProt:P22670 RFX1
0.543
3
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate [ChEBI:16618]
6
PI(3,4,5)P3 [endocytic vesicle membrane]
(R-ALL-917725)
PIP3 [plasma membrane]
(R-ALL-38117)
PI(3,4,5)P3 [endosome membrane]
(R-ALL-917716)
PI(3,4,5)P3 [early endosome membrane]
(R-ALL-8849955)
PI(3,4,5)P3 [cytoplasmic vesicle membrane]
(R-ALL-8874468)
PI(3,4,5)P3 [plasma membrane]
(R-ALL-179838)
0.462
2
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