Reactome | TNS4 [cytosol]

TNS4 [cytosol]

Stable Identifier

R-HSA-201624

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Tensin-4

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by MET (Homo sapiens)
    - MET promotes cell motility (Homo sapiens)
      - MET interacts with TNS proteins (Homo sapiens)
        
        MET binds TNS4 (Homo sapiens)
        
        HGF:p-4Y-MET dimer:TNS4:ITGB1 [plasma membrane] (Homo sapiens)
        
        TNS4:ITGB1 [plasma membrane] (Homo sapiens)
        
        TNS4 [cytosol] (Homo sapiens)
        
        TNS4:ITGB1 [plasma membrane] (Homo sapiens)
        
        TNS4 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q8IZW8 TNS4

Gene Names

TNS4, CTEN, PP14434

Chain

signal peptide:1-18, chain:19-715

Reference Genes

BioGPS Gene:84951 TNS4

COSMIC (genes):TNS4 TNS4

CTD Gene:84951 TNS4

dbSNP Gene:84951 TNS4

ENSEMBL:ENSG00000131746 TNS4

ENSEMBL_homo_sapiens_GENE:ENSG00000131746.13 TNS4

HGNC:24352 TNS4

KEGG Gene (Homo sapiens):84951 TNS4

Monarch:84951 TNS4

NCBI Gene:84951 TNS4

OMIM:608385 TNS4

UCSC:Q8IZW8 TNS4

Reference Transcript

RefSeq:NM_032865.5 TNS4

Other Identifiers

11724151_a_at

11724152_a_at

16844356

222265_PM_at

222265_at

230398_PM_at

230398_at

3756266

3756267

3756268

3756269

3756271

3756272

3756273

3756276

3756279

3756281

3756282

3756285

3756288

3756289

3756290

3756291

3756292

3756297

3756298

3756299

3756300

67742_at

77422_at

8015016

84951

A_23_P207850

GE83563

GE86607

GO:0003779

GO:0005515

GO:0005737

GO:0005829

GO:0005856

GO:0005925

GO:0008092

GO:0008104

GO:0043226

GO:0070161

HMNXSV003031847

Hs.165544.0.A1_3p_at

Hs.187745.0.A1_3p_at

ILMN_1716370

PH_hs_0022236

TC17001465.hg

TC17002619.hg

Participates

as a component of

TNS4:ITGB1 [plasma membrane] (Homo sapiens)

Inferred To

Tns4 [cytosol] (Mus musculus)

Tns4 [cytosol] (Rattus norvegicus)

by [cytosol] (Drosophila melanogaster)

tns-1 [cytosol] (Caenorhabditis elegans)

tns4 [cytosol] (Xenopus tropicalis)

TNS4 [cytosol] (Bos taurus)

TNS4 [cytosol] (Canis familiaris)

TNS4 [cytosol] (Gallus gallus)

TNS4 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_116254.4

OpenTargets

ENSG00000131746

GeneCards

Q8IZW8

HPA

ENSG00000131746-TNS4

Ensembl

ENST00000254051, ENSP00000254051, ENSG00000131746

PRO

Q8IZW8

Pharos - Targets

Q8IZW8

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.59	2
UniProt:P14373 TRIM27	2	TRIM27 [nucleoplasm] (R-HSA-2997690) TRIM27 [cytosol] (R-HSA-8851002)	0.556	3
UniProt:P19474 TRIM21	1	TRIM21 [cytosol] (R-HSA-976051)	0.556	3
UniProt:Q9UGI0 ZRANB1	1	ZRANB1 [cytosol] (R-HSA-6781939)	0.556	3

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