Caspase-mediated cleavage of plectin-1

Stable Identifier
R-HSA-201637
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Caspase-mediated cleavage of plectin-1
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Plectin is a major cross-linking protein of the three main cytoplasmic filament systems. Caspase-8 mediated cleavage of plectin 1 appears to contribute to disruption of the microfilament system during the early stages of apoptosis (Stegh et al., 2000).

Literature References
PubMed ID Title Journal Year
10891503 Identification of the cytolinker plectin as a major early in vivo substrate for caspase 8 during CD95- and tumor necrosis factor receptor-mediated apoptosis

Stegh, AH, Herrmann, H, Lampel, S, Weisenberger, D, Andrä, K, Seper, M, Wiche, G, Krammer, PH, Peter, ME

Mol Cell Biol 2000
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
cysteine-type endopeptidase activity of active caspase-8 [cytosol]
Physical Entity
active caspase-8 [cytosol]
Activity
cysteine-type endopeptidase activity (0004197)
Orthologous Events
Caspase-mediated cleavage of plectin-1 (Bos taurus)
Caspase-mediated cleavage of plectin-1 (Caenorhabditis elegans)
Caspase-mediated cleavage of plectin-1 (Canis familiaris)
Caspase-mediated cleavage of plectin-1 (Danio rerio)
Caspase-mediated cleavage of plectin-1 (Drosophila melanogaster)
Caspase-mediated cleavage of plectin-1 (Mus musculus)
Caspase-mediated cleavage of plectin-1 (Rattus norvegicus)
Caspase-mediated cleavage of plectin-1 (Sus scrofa)
Caspase-mediated cleavage of plectin-1 (Xenopus tropicalis)
Authored
Schulze-Osthoff, K  (2008-05-18)
Reviewed
Ranganathan, S  (2008-06-11)
Created
Matthews, L  (2007-09-03)
Cite Us!