Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha

Stable Identifier
R-HSA-201640
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Farnesyltransferase/geranyl-geranyltransferase catalyzes the transfer of a farnesyl or geranyl-geranyl moiety from farnesyl or geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. This enzyme complex consists of a heterodimer of an alpha and a beta subunit. The alpha subunit is thought to function in the formation of a stable complex with the substrate. This alpha subnit is cleaved by caspase 3. Expression of the cleavage product (60-379) induces cell death (Kim et al., 2001).

Literature References
PubMed ID Title Journal Year
11313965 Inactivation of farnesyltransferase and geranylgeranyltransferase I by caspase-3: cleavage of the common alpha subunit during apoptosis

Kim, KW, Chung, HH, Chung, CW, Kim, IK, Miura, M, Wang, S, Zhu, H, Moon, KD, Rha, GB, Park, JH, Jo, DG, Woo, HN, Song, YH, Kim, BJ, Yuan, J, Jung, YK

Oncogene 2001
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
cysteine-type endopeptidase activity of Caspase-3 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
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Created
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