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p-DVL3 [cytosol]
Stable Identifier
R-HSA-201680
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
phospho-Dvl-3
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Leishmania infection (Homo sapiens)
Killing mechanisms (Homo sapiens)
WNT5:FZD7-mediated leishmania damping (Homo sapiens)
Unknown kinase phosphorylates p-DVL (Homo sapiens)
WNT5:FZD7:p-DVL [plasma membrane] (Homo sapiens)
p-DVL [cytosol] (Homo sapiens)
p-DVL3 [cytosol] (Homo sapiens)
WNT5:FZD7 binds p-DVL (Homo sapiens)
WNT5:FZD7:p-DVL [plasma membrane] (Homo sapiens)
p-DVL [cytosol] (Homo sapiens)
p-DVL3 [cytosol] (Homo sapiens)
p-DVL [cytosol] (Homo sapiens)
p-DVL3 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by WNT (Homo sapiens)
Beta-catenin independent WNT signaling (Homo sapiens)
PCP/CE pathway (Homo sapiens)
DVL is recruited to the receptor (Homo sapiens)
WNT:FZD:pDVL [plasma membrane] (Homo sapiens)
p-DVL [cytosol] (Homo sapiens)
p-DVL3 [cytosol] (Homo sapiens)
p-DVL [cytosol] (Homo sapiens)
p-DVL3 [cytosol] (Homo sapiens)
WNT-dependent phosphorylation of DVL (Homo sapiens)
WNT:FZD:pDVL [plasma membrane] (Homo sapiens)
p-DVL [cytosol] (Homo sapiens)
p-DVL3 [cytosol] (Homo sapiens)
TCF dependent signaling in response to WNT (Homo sapiens)
WNT mediated activation of DVL (Homo sapiens)
CSNK2-mediated phosphorylation of DVL (Homo sapiens)
p-DVL [cytosol] (Homo sapiens)
p-DVL3 [cytosol] (Homo sapiens)
WNT signaling stimulates CSNK1-dependent phosphorylation of DVL (Homo sapiens)
p-DVL [cytosol] (Homo sapiens)
p-DVL3 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q92997 DVL3
Gene Names
DVL3, KIAA0208
Chain
chain:1-716
Reference Genes
BioGPS Gene:1857 DVL3
COSMIC (genes):DVL3 DVL3
CTD Gene:1857 DVL3
dbSNP Gene:1857 DVL3
ENSEMBL:ENSG00000161202 DVL3
HGNC:3087 DVL3
KEGG Gene (Homo sapiens):1857 DVL3
Monarch:1857 DVL3
NCBI Gene:1857 DVL3
OMIM:601368 DVL3
UCSC:Q92997 DVL3
Reference Transcript
RefSeq:NM_004423.3 DVL3
Other Identifiers
0003170019
11721506_a_at
11721507_at
11721508_at
11748468_a_at
16948712
1857
201907_PM_x_at
201908_PM_at
201908_at
2655439
2655440
2655441
2655444
2655445
2655446
2655448
2655452
2655453
2655454
2655455
2655458
2655459
2655461
2655462
2655463
2655466
2655467
2655468
2655469
2655470
2655471
2655472
2655473
2655474
2655475
2655477
2655478
40873_at
43731_at
8084323
A_14_P135109
A_23_P218884
A_24_P283000
A_24_P291588
D86963_at
GE58335
GO:0000785
GO:0000902
GO:0001934
GO:0002020
GO:0003674
GO:0005102
GO:0005109
GO:0005515
GO:0005575
GO:0005622
GO:0005694
GO:0005737
GO:0005829
GO:0006464
GO:0007165
GO:0007267
GO:0008013
GO:0008150
GO:0009058
GO:0009790
GO:0016055
GO:0019899
GO:0030154
GO:0031267
GO:0032880
GO:0034641
GO:0035556
GO:0035567
GO:0038031
GO:0043226
GO:0043507
GO:0043547
GO:0045893
GO:0045944
GO:0048646
GO:0048856
GO:0050821
GO:0060070
GO:0060071
GO:0090179
GO:0150012
HMNXSV003024421
ILMN_1686411
ILMN_2137464
PH_hs_0024349
TC03000993.hg
g1277022_3p_s_at
g6806886_3p_at
Participates
as a member of
p-DVL [cytosol] (Homo sapiens)
as a candidate of
p-DVL [cytosol] (Homo sapiens)
Other forms of this molecule
pp-DVL3 [cytosol]
DVL3 [cytosol]
ub-DVL3 [cytosol]
Inferred To
Homologues of p-DVL3 [cytosol]
(Caenorhabditis elegans)
phospho-DVL2 [cytosol]
(Gallus gallus)
phospho-dsh-1 [cytosol]
(Caenorhabditis elegans)
phospho-DVL3 [cytosol]
(Bos taurus)
phospho-DVL3 [cytosol]
(Canis familiaris)
phospho-DVL3 [cytosol]
(Sus scrofa)
phospho-dsh [cytosol]
(Drosophila melanogaster)
phospho-Dvl3 [cytosol]
(Mus musculus)
phospho-Dvl3 [cytosol]
(Rattus norvegicus)
phospho-dvl3b [cytosol]
(Danio rerio)
phospho-mig-5 [cytosol]
(Caenorhabditis elegans)
phospho-dsh-2 [cytosol]
(Caenorhabditis elegans)
Modified Residues
Name
phosphorylated residue at unknown position
PsiMod Name
phosphorylated residue [MOD:00696]
PsiMod Definition
A protein modification that effectively replaces a hydrogen atom with a phosphate group.
Cross References
RefSeq
NP_004414.3
OpenTargets
ENSG00000161202
HPA
ENSG00000161202-DVL3
GeneCards
Q92997
ZINC target
Q92997
Ensembl
ENSP00000405885
,
ENST00000431765
,
ENSP00000316054
,
ENST00000313143
,
ENSG00000161202
PRO
Q92997
Pharos - Targets
Q92997
ZINC - Predictions - Purchasable
DVL3_HUMAN
Orphanet
23684
PDB
6ZC6
,
6ZC8
,
6V7O
Interactors (24)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P49674 CSNK1E
2
CSNK1E [cytosol]
(R-HSA-205877)
CSNK1E [nucleoplasm]
(R-HSA-421306)
0.805
9
UniProt:P19544 WT1
1
WT1 [nucleoplasm]
(R-HSA-452420)
0.668
3
UniProt:P48730 CSNK1D
3
CSNK1D [nucleoplasm]
(R-HSA-421305)
CSNK1D [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-5685717)
CSNK1D [cytosol]
(R-HSA-380315)
0.666
4
UniProt:O14640 DVL1
4
pp-DVL1 [cytosol]
(R-HSA-3772396)
p-S-DVL1 [cytosol]
(R-HSA-201700)
DVL1 [cytosol]
(R-HSA-201687)
ub-DVL1 [cytosol]
(R-HSA-4641157)
0.633
5
UniProt:Q9UGY1 NOL12
1
NOL12 [nucleoplasm]
(R-HSA-6791195)
0.556
3
UniProt:Q8NAV1 PRPF38A
1
PRPF38A [nucleoplasm]
(R-HSA-8867897)
0.556
3
UniProt:Q12933 TRAF2
5
TRAF2 [nucleoplasm]
(R-HSA-8862199)
K63polyUb-TRAF2 [nucleoplasm]
(R-HSA-8862194)
K63polyUb-TRAF2 [cytosol]
(R-HSA-8862193)
PolyUb-TRAF2 [cytosol]
(R-HSA-6782848)
TRAF2 [cytosol]
(R-HSA-66370)
0.556
3
UniProt:Q9UPV0 CEP164
1
CEP164 [cytosol]
(R-HSA-380305)
0.556
5
UniProt:Q15696 ZRSR2
1
ZRSR2 [nucleoplasm]
(R-HSA-8865914)
0.556
3
UniProt:O43159 RRP8
1
RRP8 [nucleoplasm]
(R-HSA-427524)
0.556
3
UniProt:Q96T60 PNKP
1
PNKP [nucleoplasm]
(R-HSA-5649651)
0.556
3
UniProt:Q9UIH9 KLF15
1
KLF15 [nucleoplasm]
(R-HSA-8878735)
0.556
5
UniProt:O76024 WFS1
3
WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956747)
p-WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956998)
WFS1 [endoplasmic reticulum membrane]
(R-HSA-535474)
0.556
3
UniProt:P23025 XPA
1
XPA [nucleoplasm]
(R-HSA-67437)
0.556
3
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.556
3
UniProt:O75689 ADAP1
1
ADAP1 [cytosol]
(R-HSA-9612262)
0.556
3
UniProt:Q9UBU9 NXF1
2
NXF1 [cytosol]
(R-HSA-156481)
NXF1 [nucleoplasm]
(R-HSA-111690)
0.556
3
UniProt:P54646 PRKAA2
4
PRKAA2 [cytosol]
(R-HSA-200405)
p-T172-PRKAA2 [cytosol]
(R-HSA-200417)
p-T172-PRKAA2 [nucleoplasm]
(R-HSA-164171)
PRKAA2 [nucleoplasm]
(R-HSA-163682)
0.556
3
UniProt:O14503 BHLHE40
1
BHLHE40 [nucleoplasm]
(R-HSA-879741)
0.556
3
UniProt:O43463 SUV39H1
1
SUV39H1 [nucleoplasm]
(R-HSA-427517)
0.556
3
UniProt:O43474 KLF4
1
KLF4 [nucleoplasm]
(R-HSA-434463)
0.556
3
UniProt:O95363 FARS2
1
FARS2(1-?) [mitochondrial matrix]
(R-HSA-379565)
0.556
3
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.543
4
UniProt:Q96EB6 SIRT1
1
SIRT1 [nucleoplasm]
(R-HSA-427531)
0.524
3
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