Reactome | CSNK2-mediated phosphorylation of DVL

CSNK2-mediated phosphorylation of DVL

Stable Identifier

R-HSA-201717

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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DVL proteins from Drosophila, Xenopus, mouse and human cells have been shown to be phosphorylated, however the role of phosphorylation remains incompletely understood (Willert et al, 1997; Semenov and Synder, 1997; Yanagawa et al, 1995; Rothbächer et al, 2000). CSNK2 was identified as a DVL-associated kinase in Drosophila cells, and was shown to mediate the phosphorylation of serine and threonine residues in vitro (Willert et al, 1997). CSNK2-mediated phosphorylation of DVL may be constitutive, as DVL exists as a phosphoprotein even in the absence of WNT signaling (Bernatik et al, 2011). The association between DVL and CSNK2 may be enhanced upon WNT signaling, leading to increased levels of DVL phosphorylation (Willert et al, 2007).

Literature References

PubMed ID	Title	Journal	Year
7744250	The dishevelled protein is modified by wingless signaling in Drosophila Yanagawa, S, Klingensmith, J, Wodarz, A, Nusse, R, van Leeuwen, F	Genes Dev.	1995
10698942	Dishevelled phosphorylation, subcellular localization and multimerization regulate its role in early embryogenesis Laurent, MN, Rothbächer, U, Klein, PS, Deardorff, MA, Cho, KW, Fraser, SE	EMBO J.	2000
9214626	Casein kinase 2 associates with and phosphorylates dishevelled Varmus, H, Wodarz, A, Nusse, R, Willert, K, Brink, M	EMBO J.	1997
9192851	Human dishevelled genes constitute a DHR-containing multigene family Semënov, MV, Snyder, M	Genomics	1997
21285348	Sequential activation and inactivation of Dishevelled in the Wnt/beta-catenin pathway by casein kinases Polonio, T, Schulte, G, Bernatik, O, Bryja, V, Konik, P, Ganji, RS, Krejci, P, Cervenka, I, Dijksterhuis, JP	J. Biol. Chem.	2011