The ligand trap binds the ligand BMP2, blocking BMP signalling

Stable Identifier
R-HSA-201810
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
The ligand trap binds the ligand BMP2, blocking BMP signalling
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

BMP ligand traps are cystine-knot containing proteins which bind BMPs and antagonise their actions. They are active during organ development and morphogenesis. Different BMP ligand traps show specific spatio-temporal expression during development, and selective activity against specific BMP ligands.

Literature References
PubMed ID Title Journal Year
17029022 Bone morphogenetic proteins and their antagonists

Gazzerro, E, Canalis, E

Rev Endocr Metab Disord 2006
Participants
Input
Output
Participant Of
hasEvent
Event Information
Go Biological Process
sequestering of BMP from receptor via BMP binding (0038098)
Orthologous Events
The ligand trap binds the ligand BMP2, blocking BMP signalling (Bos taurus)
The ligand trap binds the ligand BMP2, blocking BMP signalling (Caenorhabditis elegans)
The ligand trap binds the ligand BMP2, blocking BMP signalling (Canis familiaris)
The ligand trap binds the ligand BMP2, blocking BMP signalling (Danio rerio)
The ligand trap binds the ligand BMP2, blocking BMP signalling (Mus musculus)
The ligand trap binds the ligand BMP2, blocking BMP signalling (Rattus norvegicus)
The ligand trap binds the ligand BMP2, blocking BMP signalling (Sus scrofa)
The ligand trap binds the ligand BMP2, blocking BMP signalling (Xenopus tropicalis)
Authored
Huminiecki, L  (2007-11-07)
Moustakas, A  (2007-11-07)
Reviewed
Heldin, CH  (2007-11-12)
Created
Jassal, B  (2007-09-25)