The ligand trap binds the ligand BMP2, blocking BMP signalling

Stable Identifier
R-HSA-201810
Type
Reaction
Species
Homo sapiens
Compartment
extracellular region
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Summation

BMP ligand traps are cystine-knot containing proteins which bind BMPs and antagonise their actions. They are active during organ development and morphogenesis. Different BMP ligand traps show specific spatio-temporal expression during development, and selective activity against specific BMP ligands.

Literature References
PubMed ID Title Journal Year
17029022 Bone morphogenetic proteins and their antagonists

Gazzerro, E, Canalis, E

Rev Endocr Metab Disord 2006
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Orthologous Events
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Authored
Huminiecki, L  (2007-11-07)
Moustakas, A  (2007-11-07)
Reviewed
Heldin, CH  (2007-11-12)