Smad6 and Smad7, the two I-Smads, bind directly to the BMP type I receptors and recruit the ubiquitin ligase Smurf1. This reaction leads to competitive inhibition of R-Smad binding to the type I receptor and activating phosphorylation by the receptor, and also leads to BMP receptor ubiquitination and degradation.
Tanaka, K, Chiba, T, Miyazono, K, Murakami, G, Fukuchi, M, Ebisawa, T, Imamura, T
Miyazono, K, Murakami, G, Imamura, T, Takaoka, K, Watabe, T
Miyazono, K, Murakami, G, Shimanuki, T, Fukuchi, M, Shikauchi, Y, Imamura, T, Suzuki, C
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