Smad6 and Smad7, the two I-Smads, bind directly to the BMP type I receptors and recruit the ubiquitin ligase Smurf1. This reaction leads to competitive inhibition of R-Smad binding to the type I receptor and activating phosphorylation by the receptor, and also leads to BMP receptor ubiquitination and degradation.
Murakami, G, Watabe, T, Takaoka, K, Miyazono, K, Imamura, T
Ebisawa, T, Fukuchi, M, Murakami, G, Chiba, T, Tanaka, K, Imamura, T, Miyazono, K
Suzuki, C, Murakami, G, Fukuchi, M, Shimanuki, T, Shikauchi, Y, Imamura, T, Miyazono, K
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