Reactome: A Curated Pathway Database

I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated

Stable Identifier
R-HSA-201821
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Smad6 and Smad7, the two I-Smads, bind directly to the BMP type I receptors and recruit the ubiquitin ligase Smurf1. This reaction leads to competitive inhibition of R-Smad binding to the type I receptor and activating phosphorylation by the receptor, and also leads to BMP receptor ubiquitination and degradation.

Literature References
Participants
Participant Of
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Orthologous Events