Reactome | I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated

I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated

Stable Identifier

R-HSA-201821

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytoplasmic side of plasma membrane

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I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated

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Smad6 and Smad7, the two I-Smads, bind directly to the BMP type I receptors and recruit the ubiquitin ligase Smurf1. This reaction leads to competitive inhibition of R-Smad binding to the type I receptor and activating phosphorylation by the receptor, and also leads to BMP receptor ubiquitination and degradation.

Literature References

PubMed ID	Title	Journal	Year
12857866	Cooperative inhibition of bone morphogenetic protein signaling by Smurf1 and inhibitory Smads Murakami, G, Watabe, T, Takaoka, K, Miyazono, K, Imamura, T	Mol Biol Cell	2003
11278251	Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation Ebisawa, T, Fukuchi, M, Murakami, G, Chiba, T, Tanaka, K, Imamura, T, Miyazono, K	J Biol Chem	2001
12151385	Smurf1 regulates the inhibitory activity of Smad7 by targeting Smad7 to the plasma membrane Suzuki, C, Murakami, G, Fukuchi, M, Shimanuki, T, Shikauchi, Y, Imamura, T, Miyazono, K	J Biol Chem	2002