Reactome: A Curated Pathway Database

I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated

Stable Identifier
R-HSA-201821
Type
Reaction
Species
Homo sapiens
Compartment
cytoplasmic side of plasma membrane
Locations in the PathwayBrowser
Summation

Smad6 and Smad7, the two I-Smads, bind directly to the BMP type I receptors and recruit the ubiquitin ligase Smurf1. This reaction leads to competitive inhibition of R-Smad binding to the type I receptor and activating phosphorylation by the receptor, and also leads to BMP receptor ubiquitination and degradation.

Literature References
PubMed ID Title Journal Year
12857866 Cooperative inhibition of bone morphogenetic protein signaling by Smurf1 and inhibitory Smads Mol Biol Cell 2003
11278251 Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation J Biol Chem 2001
12151385 Smurf1 regulates the inhibitory activity of Smad7 by targeting Smad7 to the plasma membrane J Biol Chem 2002
Participants
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output
Participant Of
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Orthologous Events
 
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