Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
ACTG1 [cytosol]
Stable Identifier
R-HSA-201858
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
cytoplasmic actin 2
Locations in the PathwayBrowser
Expand all
Cell-Cell communication (Homo sapiens)
Cell junction organization (Homo sapiens)
Cell-cell junction organization (Homo sapiens)
Adherens junctions interactions (Homo sapiens)
Interaction of Afadin with F-actin (Homo sapiens)
Afadin:F-actin [cytosol] (Homo sapiens)
F-actin [cytosol] (Homo sapiens)
G-actin [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
F-actin [cytosol] (Homo sapiens)
G-actin [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
Cell-extracellular matrix interactions (Homo sapiens)
MigFilin associates with Filamin and F-actin (Homo sapiens)
F-actin [cytosol] (Homo sapiens)
G-actin [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
Migfilin:Filamin A:F-actin [cytosol] (Homo sapiens)
F-actin [cytosol] (Homo sapiens)
G-actin [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
EPH-Ephrin signaling (Homo sapiens)
EPHB-mediated forward signaling (Homo sapiens)
N-WASP binds ARP2/3 and G-actin (Homo sapiens)
G-actin [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
p-EPHBs:EFNBs:ITSN1:N-WASP:CDC42:GTP:PI(4,5)P2:ARP2/3;G-actin [plasma membrane] (Homo sapiens)
G-actin [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
L1CAM interactions (Homo sapiens)
Interaction between L1 and Ankyrins (Homo sapiens)
Ankyrins link voltage-gated sodium and potassium channels to spectrin and L1 (Homo sapiens)
NFASC:NRCAM:ANK1-3:SPTA:SPTB:F-actin [plasma membrane] (Homo sapiens)
SPTA:SPTB:F-actin [cytosol] (Homo sapiens)
F-actin [cytosol] (Homo sapiens)
G-actin [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
NFASC:NRCAM:ANK1-3:SPTA:SPTB:F-actin:KCNQ2,3, SCNAs:SCNBs [plasma membrane] (Homo sapiens)
NFASC:NRCAM:ANK1-3:SPTA:SPTB:F-actin [plasma membrane] (Homo sapiens)
SPTA:SPTB:F-actin [cytosol] (Homo sapiens)
F-actin [cytosol] (Homo sapiens)
G-actin [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
L1 linked to actin cytoskeleton by ankyrin (Homo sapiens)
L1 dimer:Ankyrin:Spectrin:F-actin [plasma membrane] (Homo sapiens)
SPTA:SPTB:F-actin [cytosol] (Homo sapiens)
F-actin [cytosol] (Homo sapiens)
G-actin [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
SPTA:SPTB:F-actin [cytosol] (Homo sapiens)
F-actin [cytosol] (Homo sapiens)
G-actin [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
Recycling pathway of L1 (Homo sapiens)
Dephosphorylation of pL1 (Y1176) (Homo sapiens)
F-actin [cytosol] (Homo sapiens)
G-actin [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
pL1:ERM:F-actin [plasma membrane] (Homo sapiens)
F-actin [cytosol] (Homo sapiens)
G-actin [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
Linkage of L1 with treadmilling F-actin (Homo sapiens)
F-actin [cytosol] (Homo sapiens)
G-actin [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
pL1:ERM:F-actin [plasma membrane] (Homo sapiens)
F-actin [cytosol] (Homo sapiens)
G-actin [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
Shootin-1 links L1 and retrograde actin flow (Homo sapiens)
F-actin [cytosol] (Homo sapiens)
G-actin [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
pL1:Shootin-1:F-actin [plasma membrane] (Homo sapiens)
F-actin [cytosol] (Homo sapiens)
G-actin [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Parasitic Infection Pathways (Homo sapiens)
Leishmania infection (Homo sapiens)
Parasite infection (Homo sapiens)
Leishmania phagocytosis (Homo sapiens)
FCGR3A-mediated phagocytosis (Homo sapiens)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Homo sapiens)
F-actin [cytosol] (Homo sapiens)
G-actin [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
Mother filament:branching complex [cytosol] (Homo sapiens)
F-actin [cytosol] (Homo sapiens)
G-actin [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
G-actin [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
G-actin [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
Branching and elongation of mother and daughter filaments (Homo sapiens)
G-actin [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
Mother filament:ARP2/3:actin:ADP [cytosol] (Homo sapiens)
Actin:ADP [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
F-actin [cytosol] (Homo sapiens)
G-actin [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
Mother filament:branching complex:daughter filament [cytosol] (Homo sapiens)
F-actin [cytosol] (Homo sapiens)
G-actin [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
Detachment of WASP/WAVE (Homo sapiens)
Mother filament:ARP2/3:actin:ADP [cytosol] (Homo sapiens)
Actin:ADP [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
F-actin [cytosol] (Homo sapiens)
G-actin [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
Mother filament:branching complex [cytosol] (Homo sapiens)
F-actin [cytosol] (Homo sapiens)
G-actin [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
G-actin [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
Extension of pseudopodia by myosin-X in a PI3K dependent manner (Homo sapiens)
Actin filament bound Myosin-X [plasma membrane] (Homo sapiens)
Mother filament:branching complex:daughter filament [cytosol] (Homo sapiens)
F-actin [cytosol] (Homo sapiens)
G-actin [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
Mother filament:branching complex:daughter filament [cytosol] (Homo sapiens)
F-actin [cytosol] (Homo sapiens)
G-actin [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
IgG:Leishmania surface:FCGR3A translocates from plasma membrane to the parasitophorous vacuole (Homo sapiens)
Mother filament:branching complex:daughter filament [cytosol] (Homo sapiens)
F-actin [cytosol] (Homo sapiens)
G-actin [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
Myosin-Actin filaments [cytosol] (Homo sapiens)
Mother filament:branching complex:daughter filament [cytosol] (Homo sapiens)
F-actin [cytosol] (Homo sapiens)
G-actin [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
WASPs or WAVEs activate the ARP2/3 complex (Homo sapiens)
G-actin [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
G-actin [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
Extracellular matrix organization (Homo sapiens)
Non-integrin membrane-ECM interactions (Homo sapiens)
Formation of the dystrophin-glycoprotein complex (DGC) (Homo sapiens)
DGC complex binds AGRN and HSPG2 (Homo sapiens)
DGC complex:laminins:F-actin [plasma membrane] (Homo sapiens)
F-actin (all) [cytosol] (Homo sapiens)
actins:ATP [cytosol] (Homo sapiens)
(ACTA1,ACTC1),(ACTB,ACTG1),(ACTA2,ACTG2) (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
DGC complex:laminins:F-actin:AGRN,HSPG2 [plasma membrane] (Homo sapiens)
DGC complex:laminins:F-actin [plasma membrane] (Homo sapiens)
F-actin (all) [cytosol] (Homo sapiens)
actins:ATP [cytosol] (Homo sapiens)
(ACTA1,ACTC1),(ACTB,ACTG1),(ACTA2,ACTG2) (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
DGC:laminin complex binds F-actin (Homo sapiens)
DGC complex:laminins:F-actin [plasma membrane] (Homo sapiens)
F-actin (all) [cytosol] (Homo sapiens)
actins:ATP [cytosol] (Homo sapiens)
(ACTA1,ACTC1),(ACTB,ACTG1),(ACTA2,ACTG2) (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
F-actin (all) [cytosol] (Homo sapiens)
actins:ATP [cytosol] (Homo sapiens)
(ACTA1,ACTC1),(ACTB,ACTG1),(ACTA2,ACTG2) (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Fcgamma receptor (FCGR) dependent phagocytosis (Homo sapiens)
Regulation of actin dynamics for phagocytic cup formation (Homo sapiens)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Homo sapiens)
F-actin [cytosol] (Homo sapiens)
G-actin [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
Mother filament:branching complex [cytosol] (Homo sapiens)
F-actin [cytosol] (Homo sapiens)
G-actin [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
G-actin [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
G-actin [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
Branching and elongation of mother and daughter filaments (Homo sapiens)
G-actin [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
Mother filament:ARP2/3:actin:ADP [cytosol] (Homo sapiens)
Actin:ADP [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
F-actin [cytosol] (Homo sapiens)
G-actin [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
Mother filament:branching complex:daughter filament [cytosol] (Homo sapiens)
F-actin [cytosol] (Homo sapiens)
G-actin [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
Detachment of WASP/WAVE (Homo sapiens)
Mother filament:ARP2/3:actin:ADP [cytosol] (Homo sapiens)
Actin:ADP [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
F-actin [cytosol] (Homo sapiens)
G-actin [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
Mother filament:branching complex [cytosol] (Homo sapiens)
F-actin [cytosol] (Homo sapiens)
G-actin [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
G-actin [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
Extension of pseudopodia by myosin-X in a PI3K dependent manner (Homo sapiens)
Actin filament bound Myosin-X [plasma membrane] (Homo sapiens)
Mother filament:branching complex:daughter filament [cytosol] (Homo sapiens)
F-actin [cytosol] (Homo sapiens)
G-actin [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
Mother filament:branching complex:daughter filament [cytosol] (Homo sapiens)
F-actin [cytosol] (Homo sapiens)
G-actin [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
Role of myosins in phagosome formation (Homo sapiens)
Mother filament:branching complex:daughter filament [cytosol] (Homo sapiens)
F-actin [cytosol] (Homo sapiens)
G-actin [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
Myosin-Actin filaments [cytosol] (Homo sapiens)
Mother filament:branching complex:daughter filament [cytosol] (Homo sapiens)
F-actin [cytosol] (Homo sapiens)
G-actin [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
WASPs or WAVEs activate the ARP2/3 complex (Homo sapiens)
G-actin [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
G-actin [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
Sensory Perception (Homo sapiens)
Sensory processing of sound (Homo sapiens)
Sensory processing of sound by inner hair cells of the cochlea (Homo sapiens)
Mechanoelectrical transduction (MET) channel transports cations from the extracellular region into the cytosol of stereocilia of inner hair cell (Homo sapiens)
MET channel:Tip link:USH1C:USH1G:MYO7A:cytoskeleton (IHC) [plasma membrane] (Homo sapiens)
Inner hair cell stereocilium cytoskeleton [cytosol] (Homo sapiens)
Inner hair cell stereocilium tip [cytosol] (Homo sapiens)
F-Actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
Stereocilium cuticular plate [cytosol] (Homo sapiens)
F-Actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
Stereocilium rootlet [cytosol] (Homo sapiens)
F-Actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
Stereocilium shaft [cytosol] (Homo sapiens)
F-Actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
Sensory processing of sound by outer hair cells of the cochlea (Homo sapiens)
Mechanoelectrical transduction (MET) channel transports cations into the cytosol of stereocilia of cochlear outer hair cell (Homo sapiens)
MET channel:Tip link:USH1C:USH1G:MYO7A:cytoskeleton (OHC) [plasma membrane] (Homo sapiens)
Outer hair cell stereocilium cytoskeleton [cytosol] (Homo sapiens)
Outer hair cell stereocilium tip [cytosol] (Homo sapiens)
F-Actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
Stereocilium cuticular plate [cytosol] (Homo sapiens)
F-Actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
Stereocilium rootlet [cytosol] (Homo sapiens)
F-Actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
Stereocilium shaft [cytosol] (Homo sapiens)
F-Actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by VEGF (Homo sapiens)
VEGFA-VEGFR2 Pathway (Homo sapiens)
p-MAPK2/3 phosphorylates HSP27 (Homo sapiens)
F-actin [cytosol] (Homo sapiens)
G-actin [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
HSP27 oligomer:F-actin [cytosol] (Homo sapiens)
F-actin [cytosol] (Homo sapiens)
G-actin [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases Activate Formins (Homo sapiens)
Activated FMNL3 binds G-actin (Homo sapiens)
Profilin:G-actin [cytosol] (Homo sapiens)
G-actin [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
RHOC:GTP:FMNL3:G-actin [plasma membrane] (Homo sapiens)
Profilin:G-actin [cytosol] (Homo sapiens)
G-actin [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
Association of profilin with monomeric actin (Homo sapiens)
G-actin [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
Profilin:G-actin [cytosol] (Homo sapiens)
G-actin [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
CDC42:GTP:FMNL2 binds Profilin:G-actin (Homo sapiens)
CDC42:FMNL2:Profilin:G-actin [plasma membrane] (Homo sapiens)
Profilin:G-actin [cytosol] (Homo sapiens)
G-actin [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
Profilin:G-actin [cytosol] (Homo sapiens)
G-actin [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
Profilin:G-actin binds MKL1 (Homo sapiens)
Profilin:G-actin [cytosol] (Homo sapiens)
G-actin [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
Profilin:G-actin:MKL1 [cytosol] (Homo sapiens)
Profilin:G-actin [cytosol] (Homo sapiens)
G-actin [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
RAC1:GTP:FMNL1 binds profilin:G-actin (Homo sapiens)
Profilin:G-actin [cytosol] (Homo sapiens)
G-actin [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
RAC1:GTP:FMNL1:Profilin:G-actin [plasma membrane] (Homo sapiens)
Profilin:G-actin [cytosol] (Homo sapiens)
G-actin [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
RHOA:GTP:DIAPH1 binds EVL and sequesters profilin:G-actin from MKL1 (Homo sapiens)
Profilin:G-actin:MKL1 [cytosol] (Homo sapiens)
Profilin:G-actin [cytosol] (Homo sapiens)
G-actin [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
RHOA:GTP:DIAPH1:EVL:Profilin:G-actin [plasma membrane] (Homo sapiens)
Profilin:G-actin [cytosol] (Homo sapiens)
G-actin [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
SRGAP2 binds RAC1:GTP:FMNL1:profilin:G-actin (Homo sapiens)
RAC1:GTP:FMNL1:Profilin:G-actin [plasma membrane] (Homo sapiens)
Profilin:G-actin [cytosol] (Homo sapiens)
G-actin [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
SRGAP2:RAC1:GTP:FMNL1:Profilin:G-actin [plasma membrane] (Homo sapiens)
RAC1:GTP:FMNL1:Profilin:G-actin [plasma membrane] (Homo sapiens)
Profilin:G-actin [cytosol] (Homo sapiens)
G-actin [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments (Homo sapiens)
Profilin:G-actin [cytosol] (Homo sapiens)
G-actin [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
SRGAP2:RAC1:GTP:FMNL1:Profilin:G-actin [plasma membrane] (Homo sapiens)
RAC1:GTP:FMNL1:Profilin:G-actin [plasma membrane] (Homo sapiens)
Profilin:G-actin [cytosol] (Homo sapiens)
G-actin [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
RHO GTPases Activate WASPs and WAVEs (Homo sapiens)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Homo sapiens)
F-actin [cytosol] (Homo sapiens)
G-actin [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
Mother filament:branching complex [cytosol] (Homo sapiens)
F-actin [cytosol] (Homo sapiens)
G-actin [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
G-actin [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
G-actin [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
Branching and elongation of mother and daughter filaments (Homo sapiens)
G-actin [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
Mother filament:ARP2/3:actin:ADP [cytosol] (Homo sapiens)
Actin:ADP [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
F-actin [cytosol] (Homo sapiens)
G-actin [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
Mother filament:branching complex:daughter filament [cytosol] (Homo sapiens)
F-actin [cytosol] (Homo sapiens)
G-actin [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
Detachment of WASP/WAVE (Homo sapiens)
Mother filament:ARP2/3:actin:ADP [cytosol] (Homo sapiens)
Actin:ADP [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
F-actin [cytosol] (Homo sapiens)
G-actin [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
Mother filament:branching complex [cytosol] (Homo sapiens)
F-actin [cytosol] (Homo sapiens)
G-actin [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
G-actin [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
WASPs or WAVEs activate the ARP2/3 complex (Homo sapiens)
G-actin [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
G-actin [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
RHO GTPases activate IQGAPs (Homo sapiens)
IQGAPs bind F-actin, which is inhibited by calmodulin (Homo sapiens)
F-actin [cytosol] (Homo sapiens)
G-actin [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
RAC1,CDC42:GTP:IQGAP:F-actin [plasma membrane] (Homo sapiens)
F-actin [cytosol] (Homo sapiens)
G-actin [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
RHOBTB GTPase Cycle (Homo sapiens)
RHOBTB2 GTPase cycle (Homo sapiens)
RHOBTB2 binds interacting proteins at the endosome membrane (Homo sapiens)
RHOBTB2 interacting proteins [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
RHOBTB2:GTP:RHOBTB2 interacting proteins [endosome membrane] (Homo sapiens)
RHOBTB2 interacting proteins [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
Translocation of SLC2A4 (GLUT4) to the plasma membrane (Homo sapiens)
RALA:GTP binds MYO1C:CALM1 and activates MYO1C (Homo sapiens)
GGC-RALA:GTP:MYO1C:Calmodulin:F-actin [cytoplasmic vesicle membrane] (Homo sapiens)
f-actin (ADP) [cytosol] (Homo sapiens)
Actin:ADP [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
f-actin (ADP) [cytosol] (Homo sapiens)
Actin:ADP [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
SLC2A4 (GLUT4) vesicle translocates and docks at the plasma membrane (Homo sapiens)
GGC-RALA:GTP:MYO1C:Calmodulin:F-actin [cytoplasmic vesicle membrane] (Homo sapiens)
f-actin (ADP) [cytosol] (Homo sapiens)
Actin:ADP [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
GGC-RALA:GTP:MYO1C:Exocyst [plasma membrane] (Homo sapiens)
GGC-RALA:GTP:MYO1C:Calmodulin:F-actin [cytoplasmic vesicle membrane] (Homo sapiens)
f-actin (ADP) [cytosol] (Homo sapiens)
Actin:ADP [cytosol] (Homo sapiens)
actin [cytosol] (Homo sapiens)
ACTG1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P63261 ACTG1
Gene Names
ACTG1, ACTG
Chain
chain:1-375, initiator methionine:, chain:2-375
Reference Genes
BioGPS Gene:71 ACTG1
COSMIC (genes):ACTG1 ACTG1
CTD Gene:71 ACTG1
dbSNP Gene:71 ACTG1
ENSEMBL:ENSG00000184009 ACTG1
HGNC:144 ACTG1
KEGG:hsa:71 ACTG1
Monarch:71 ACTG1
NCBI Gene:71 ACTG1
OMIM:102560 ACTG1
UCSC:P63261 ACTG1
Reference Transcript
RefSeq:NM_001199954.1 ACTG1
RefSeq:NM_001614.3 ACTG1
Other Identifiers
11752959_x_at
11754217_x_at
11757807_x_at
11758042_x_at
11762785_x_at
16849849
201550_3p_x_at
201550_PM_x_at
201550_x_at
211970_PM_x_at
211970_x_at
211983_PM_x_at
211983_x_at
211995_3p_x_at
211995_PM_x_at
211995_x_at
212363_3p_x_at
212363_PM_x_at
212363_x_at
212988_PM_x_at
212988_x_at
213214_3p_x_at
213214_PM_x_at
213214_x_at
221607_3p_x_at
221607_PM_x_at
221607_x_at
224585_3p_x_at
224585_PM_x_at
224585_x_at
2349440
2387414
34160_at
3621802
3773933
3773934
3773935
3773936
3773937
3773938
3773940
3773941
3773942
3773943
3773944
3773945
3773946
3773947
3773948
3773949
3773950
3773951
3773952
3773953
3773954
3773956
3773969
43831_s_at
51746_f_at
71
8019183
A_23_P44037
GE80152
GO:0001525
GO:0001738
GO:0003824
GO:0005198
GO:0005200
GO:0005515
GO:0005522
GO:0005524
GO:0005615
GO:0005634
GO:0005737
GO:0005829
GO:0005856
GO:0005884
GO:0005886
GO:0005911
GO:0005925
GO:0007010
GO:0007155
GO:0007409
GO:0010628
GO:0015629
GO:0016020
GO:0016787
GO:0019901
GO:0030016
GO:0030335
GO:0030424
GO:0031410
GO:0031625
GO:0031941
GO:0034330
GO:0035267
GO:0035633
GO:0042802
GO:0043226
GO:0043296
GO:0044305
GO:0045177
GO:0045202
GO:0045214
GO:0045335
GO:0048870
GO:0051492
GO:0051893
GO:0070062
GO:0070527
GO:0071346
GO:0072562
GO:0090303
GO:0097433
GO:0098685
GO:0098973
GO:0098974
GO:0120192
GO:0120220
GO:0150111
GO:1900242
GO:1902396
HMNXSV003039797
HMNXSV003044768
Hs.14376.2.A1_3p_x_at
Hs.14376.3.A1_3p_a_at
Hs.14376.3.A1_3p_x_at
Hs.14376.4.A1_3p_x_at
Hs.14376.5.A1_3p_a_at
Hs.14376.5.A1_3p_x_at
Hs.14376.6.S1_3p_a_at
Hs.14376.6.S1_3p_s_at
Hs.14376.7.A1_3p_a_at
Hs.14376.7.A1_3p_x_at
Hs.14376.9.A1_3p_a_at
Hs.14376.9.A1_3p_x_at
ILMN_1704961
ILMN_2053178
M19283_at
PH_hs_0028775
PH_hs_0031012
TC06001971.hg
TC17001952.hg
TC17002825.hg
g11038618_3p_a_at
g11038618_3p_s_at
g12804934_3p_a_at
g12804934_3p_s_at
g12804934_3p_x_at
Participates
as a candidate of
RHOBTB2 interacting proteins [cytosol] (Homo sapiens)
as a repeated unit of
F-Actin [cytosol] (Homo sapiens)
as a member of
actin [cytosol] (Homo sapiens)
Other forms of this molecule
ACTG1 [plasma membrane]
ACTG1 [lysosomal membrane]
Inferred To
Actin, cytoplasmic 2 [cytosol]
(Mus musculus)
arp9 [cytosol]
(Schizosaccharomyces pombe)
ACTG1 [cytosol]
(Bos taurus)
ACTG1 [cytosol]
(Canis familiaris)
ACTG1 [cytosol]
(Gallus gallus)
ACTG1 [cytosol]
(Sus scrofa)
actb [cytosol]
(Xenopus tropicalis)
act-2 [cytosol]
(Caenorhabditis elegans)
actbb [cytosol]
(Danio rerio)
act-3 [cytosol]
(Caenorhabditis elegans)
act26 [cytosol]
(Dictyostelium discoideum)
Homologues of ACTG1 [cytosol]
(Caenorhabditis elegans)
Homologues of ACTG1 [cytosol]
(Drosophila melanogaster)
Homologues of ACTG1 [cytosol]
(Schizosaccharomyces pombe)
Act5C [cytosol]
(Drosophila melanogaster)
act-4 [cytosol]
(Caenorhabditis elegans)
ARP9 [cytosol]
(Saccharomyces cerevisiae)
Actin [cytosol]
(Rattus norvegicus)
Act42A [cytosol]
(Drosophila melanogaster)
act-1 [cytosol]
(Caenorhabditis elegans)
arp10 [cytosol]
(Schizosaccharomyces pombe)
Cross References
RefSeq
NP_001605.1
,
NP_001186883.1
OpenTargets
ENSG00000184009
ENSEMBL
ENSP00000516881
,
ENST00000679480
,
ENSP00000459124
,
ENSP00000516877
,
ENSP00000516887
,
ENSP00000459119
,
ENSP00000516869
,
ENST00000680727
,
ENST00000707473
,
ENSP00000505060
,
ENST00000707487
,
ENST00000707469
,
ENST00000575842
,
ENST00000707470
,
ENST00000571721
,
ENST00000707472
,
ENST00000707466
,
ENST00000575659
,
ENST00000570382
,
ENSP00000516875
,
ENST00000681842
,
ENST00000707482
,
ENSP00000477968
,
ENSP00000460660
,
ENSP00000516872
,
ENSP00000506126
,
ENSP00000516874
,
ENSP00000516882
,
ENSP00000506201
,
ENSP00000516886
,
ENSP00000516879
,
ENSP00000516884
,
ENST00000707479
,
ENSP00000506253
,
ENST00000707474
,
ENSP00000458435
,
ENST00000575087
,
ENST00000707471
,
ENST00000615544
,
ENST00000707468
,
ENST00000707485
,
ENST00000679778
,
ENST00000680227
,
ENST00000707490
,
ENSP00000460464
,
ENSP00000505193
,
ENST00000707489
,
ENST00000707467
,
ENSP00000466346
,
ENSP00000516876
,
ENST00000575994
,
ENST00000576544
,
ENSP00000516870
,
ENSP00000458162
,
ENSP00000461672
,
ENSP00000505235
,
ENST00000681052
,
ENSP00000516871
,
ENST00000573283
,
ENSP00000516873
HPA
ENSG00000184009-ACTG1
PRO
P63261
Pharos - Targets
P63261
GlyGen
P63261
Orphanet
ACTG1
PDB
8DNF
,
6G2T
,
5JLH
,
6WK2
,
6CXJ
,
6CXI
,
7NVM
,
6V63
,
6WK1
,
6V62
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P60709 ACTB
5
ACTB [plasma membrane]
(R-HSA-196016)
ACTB [lysosomal membrane]
(R-HSA-196160)
ACTB [cytosol]
(R-HSA-201861)
ACTB [nucleoplasm]
(R-HSA-3321990)
Unfolded ACTB [cytosol]
(R-HSA-390462)
0.951
16
UniProt:P23528 CFL1
3
CFL1 [cytosol]
(R-HSA-350751)
p-S3-CFL1 [cytosol]
(R-HSA-399813)
CFL1 [extracellular region]
(R-HSA-350747)
0.831
10
UniProt:Q08426 EHHADH
2
EHHADH [peroxisomal matrix]
(R-HSA-400155)
EHHADH [cytosol]
(R-HSA-9033147)
0.666
4
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.666
16
UniProt:Q12933 TRAF2
5
TRAF2 [cytosol]
(R-HSA-66370)
PolyUb-TRAF2 [cytosol]
(R-HSA-6782848)
K63polyUb-TRAF2 [cytosol]
(R-HSA-8862193)
K63polyUb-TRAF2 [nucleoplasm]
(R-HSA-8862194)
TRAF2 [nucleoplasm]
(R-HSA-8862199)
0.65
3
UniProt:P40692 MLH1
3
MLH1 [nucleoplasm]
(R-HSA-912495)
MLH1 H329P [nucleoplasm]
(R-HSA-5444512)
MLH1 S252* [nucleoplasm]
(R-HSA-5444526)
0.602
6
UniProt:Q9Y6K9 IKBKG
12
IKBKG [cytosol]
(R-HSA-168108)
Ub-285-IKBKG [cytosol]
(R-HSA-741397)
K63polyUb-IKBKG [cytosol]
(R-HSA-202530)
IKBKG [nucleoplasm]
(R-HSA-4755413)
monoSUMO1-K277,K309-IKBKG [nucleoplasm]
(R-HSA-4755449)
IKBKG *420Wext*447 [cytosol]
(R-HSA-5262978)
IKBKG R175P [cytosol]
(R-HSA-5262916)
IKBKG R173G [cytosol]
(R-HSA-5262966)
IKBKG C417R [cytosol]
(R-HSA-5262858)
IKBKG E391* [cytosol]
(R-HSA-5262924)
IKBKG L153R [cytosol]
(R-HSA-5262879)
IKBKG D406V [cytosol]
(R-HSA-5262943)
0.564
2
UniProt:P10636-8 MAPT
3
MAPT-8 [cytosol]
(R-HSA-9619519)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
0.527
4
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.527
3
UniProt:P50552 VASP
1
VASP [cytosol]
(R-HSA-446323)
0.483
2
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.483
5
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text