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WIPF1 [cytosol]
Stable Identifier
R-HSA-201874
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
WIP
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Parasitic Infection Pathways (Homo sapiens)
Leishmania infection (Homo sapiens)
Parasite infection (Homo sapiens)
Leishmania phagocytosis (Homo sapiens)
FCGR3A-mediated phagocytosis (Homo sapiens)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Homo sapiens)
Mother filament:branching complex [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF1 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF1 [cytosol] (Homo sapiens)
Detachment of WASP/WAVE (Homo sapiens)
Mother filament:branching complex [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF1 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF1 [cytosol] (Homo sapiens)
Src phosphorylate WASP,N-WASP (Homo sapiens)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF1 [cytosol] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF1 [cytosol] (Homo sapiens)
WASPs or WAVEs activate the ARP2/3 complex (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF1 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF1 [cytosol] (Homo sapiens)
WIP binds WASP,N-WASP, activating them (Homo sapiens)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF1 [cytosol] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF1 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Fcgamma receptor (FCGR) dependent phagocytosis (Homo sapiens)
Regulation of actin dynamics for phagocytic cup formation (Homo sapiens)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Homo sapiens)
Mother filament:branching complex [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF1 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF1 [cytosol] (Homo sapiens)
Detachment of WASP/WAVE (Homo sapiens)
Mother filament:branching complex [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF1 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF1 [cytosol] (Homo sapiens)
Src phosphorylate WASP,N-WASP (Homo sapiens)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF1 [cytosol] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF1 [cytosol] (Homo sapiens)
WASPs or WAVEs activate the ARP2/3 complex (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF1 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF1 [cytosol] (Homo sapiens)
WIP binds WASP,N-WASP, activating them (Homo sapiens)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF1 [cytosol] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF1 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases Activate WASPs and WAVEs (Homo sapiens)
(WASPs, WAVE):G-actin:ARP2/3 binds F-actin (Homo sapiens)
Mother filament:branching complex [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF1 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF1 [cytosol] (Homo sapiens)
Detachment of WASP/WAVE (Homo sapiens)
Mother filament:branching complex [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF1 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF1 [cytosol] (Homo sapiens)
Src phosphorylate WASP,N-WASP (Homo sapiens)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF1 [cytosol] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF1 [cytosol] (Homo sapiens)
WASPs or WAVEs activate the ARP2/3 complex (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF1 [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP:ARP2/3 complex:G-actin [cytosol] (Homo sapiens)
WAVE2, WASP, N-WASP [plasma membrane] (Homo sapiens)
CDC42:GTP:p-Y-WASP/p-Y-WASL:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF1 [cytosol] (Homo sapiens)
WIP binds WASP,N-WASP, activating them (Homo sapiens)
CDC42:GTP:WASP/N-WASP:WIP:SH3 proteins [plasma membrane] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF1 [cytosol] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF1 [cytosol] (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
CDC42 GTPase cycle (Homo sapiens)
CDC42 binds effectors at the plasma membrane (Homo sapiens)
CDC42 effectors [cytosol] (Homo sapiens)
WIP:WASP complex [cytosol] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF1 [cytosol] (Homo sapiens)
CDC42:GTP:CDC42 effectors [plasma membrane] (Homo sapiens)
CDC42 effectors [cytosol] (Homo sapiens)
WIP:WASP complex [cytosol] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF1 [cytosol] (Homo sapiens)
RAC1 GTPase cycle (Homo sapiens)
RAC1 binds effectors at the plasma membrane (Homo sapiens)
RAC1 effectors [cytosol] (Homo sapiens)
WIP:WASP complex [cytosol] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF1 [cytosol] (Homo sapiens)
RAC1:GTP:RAC1 effectors [plasma membrane] (Homo sapiens)
RAC1 effectors [cytosol] (Homo sapiens)
WIP:WASP complex [cytosol] (Homo sapiens)
WIP family proteins [cytosol] (Homo sapiens)
WIPF1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O43516 WIPF1
Gene Names
WIPF1, WASPIP, WIP
Chain
chain:1-503
Reference Genes
BioGPS Gene:7456 WIPF1
COSMIC (genes):WIPF1 WIPF1
CTD Gene:7456 WIPF1
dbSNP Gene:7456 WIPF1
ENSEMBL:ENSG00000115935 WIPF1
HGNC:12736 WIPF1
KEGG:hsa:7456 WIPF1
Monarch:7456 WIPF1
NCBI Gene:7456 WIPF1
OMIM:602357 WIPF1
UCSC:O43516 WIPF1
Reference Transcript
RefSeq:NM_001077269.1 WIPF1
RefSeq:XM_011511780.2 WIPF1
RefSeq:NM_003387.4 WIPF1
Participates
as a member of
WIP family proteins [cytosol] (Homo sapiens)
Inferred To
Wipf1 [cytosol]
(Mus musculus)
Wipf1 [cytosol]
(Rattus norvegicus)
WIPF1 [cytosol]
(Canis familiaris)
WIPF1 [cytosol]
(Sus scrofa)
Cross References
OpenTargets
ENSG00000115935
ENSEMBL
ENSP00000376329
,
ENSP00000352802
,
ENSP00000386431
,
ENSP00000513869
,
ENSP00000388454
,
ENST00000272746
,
ENST00000679041
,
ENSP00000503603
,
ENSP00000376330
,
ENST00000436221
,
ENST00000409891
,
ENST00000698668
,
ENST00000359761
,
ENST00000698701
,
ENST00000392547
,
ENSG00000115935
,
ENSP00000513882
,
ENSP00000272746
,
ENST00000392546
HPA
ENSG00000115935-WIPF1
GeneCards
WIPF1
PRO
O43516
Pharos - Targets
O43516
Orphanet
WIPF1
GlyGen
O43516
PDB
2A41
Interactors (10)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P42768 WAS
2
WAS [cytosol]
(R-HSA-201879)
p-Y291-WAS [cytosol]
(R-HSA-2197668)
0.966
25
UniProt:O00401 WASL
4
N-WASP [cytosol]
(R-HSA-201873)
p-Y256-WASL [cytosol]
(R-HSA-2197672)
WASL [plasma membrane]
(R-HSA-203010)
WASL [endocytic vesicle membrane]
(R-HSA-535012)
0.92
10
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.804
5
UniProt:Q60598 Cttn
2
p-S113-Cttn [cytosol]
(R-MMU-442839)
Cttn [cytosol]
(R-MMU-442836)
0.676
4
UniProt:O00308 WWP2
1
WWP2 [cytosol]
(R-HSA-6807279)
0.666
4
UniProt:P16333 NCK1
2
NCK1 [plasma membrane]
(R-HSA-202992)
NCK1 [cytosol]
(R-HSA-197954)
0.564
3
UniProt:P53992 SEC24C
4
p-SEC24C [cytosol]
(R-HSA-5694551)
SEC24C [ER to Golgi transport vesicle membrane]
(R-HSA-204026)
SEC24C [cytosol]
(R-HSA-203988)
SEC24C [endoplasmic reticulum membrane]
(R-HSA-203987)
0.556
3
UniProt:P13196 ALAS1
2
PXLP-ALAS1 [mitochondrial matrix]
(R-HSA-1022086)
ALAS1 [mitochondrial matrix]
(R-HSA-189438)
0.556
3
UniProt:O43639 NCK2
1
NCK2 [cytosol]
(R-HSA-204885)
0.527
2
UniProt:Q9GZQ8 MAP1LC3B
3
MAP1LC3B [cytosol]
(R-HSA-5205651)
MAP1LC3B(2-121) [cytosol]
(R-HSA-5682674)
MAP1LC3B [autophagosome membrane]
(R-HSA-5683641)
0.463
4
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