Reactome | eNOS:Caveolin-1 complex binds to CaM

eNOS:Caveolin-1 complex binds to CaM

Stable Identifier

R-HSA-202110

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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Caveolin inhibition of eNOS is relieved by calmodulin, the first step in the dissociation of eNOS from caveolin (Kone at al. 2003; Michel et al. 1997).

Literature References

PubMed ID	Title	Journal	Year
9188442	Reciprocal regulation of endothelial nitric-oxide synthase by Ca2+-calmodulin and caveolin Michel, JB, Michel, T, Sacks, D, Feron, O	J Biol Chem	1997
12842859	Protein interactions with nitric oxide synthases: controlling the right time, the right place, and the right amount of nitric oxide Yu, ZY, Zhang, W, Kone, BC, Kuncewicz, T	Am J Physiol Renal Physiol	2003