Reactome | AKT1 phosphorylates eNOS

AKT1 phosphorylates eNOS

Stable Identifier

R-HSA-202111

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

Synonyms

ATP + L-seryl-(protein) => ADP + H(+) + O-phospho-L-seryl-(protein)

ReviewStatus

5/5

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HSP90 serves as a scaffold to promote productive interaction between AKT1 and eNOS. Due to the proximity of these proteins once complexed with HSP90, AKT1 phosphorylates eNOS at Ser1177. When Ser1177 is phosphorylated, the level of NO production is elevated two- to three-fold above basal level.

Literature References

PubMed ID	Title	Journal	Year
10376602	Regulation of endothelium-derived nitric oxide production by the protein kinase Akt Fontana, J, Sessa, WC, Franke, TF, Walsh, K, Fulton, D, Gratton, JP, Fujio, Y, Papapetropoulos, A, McCabe, TJ	Nature	1999
10469573	The Akt kinase signals directly to endothelial nitric oxide synthase Pearson, RB, Bozinovski, S, Rodriguez-Crespo, I, Griffiths, JE, de Montellano, PR, Kemp, BE, Tiganis, T, Mitchelhill, KI, Michell, BJ	Curr Biol	1999
10376603	Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation Hermann, C, Zeiher, AM, Fleming, I, Fisslthaler, B, Busse, R, Dimmeler, S	Nature	1999