Reactome: A Curated Pathway Database

AKT1 phosphorylates eNOS

Stable Identifier
R-HSA-202111
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

HSP90 serves as a scaffold to promote productive interaction between AKT1 and eNOS. Due to the proximity of these proteins once complexed with HSP90, AKT1 phosphorylates eNOS at Ser1177. When Ser1177 is phosphorylated, the level of NO production is elevated two- to three-fold above basal level.

Literature References
Participants
Participant Of
Orthologous Events