Reactome: A Curated Pathway Database

eNOS synthesizes NO

Stable Identifier
R-HSA-202127
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
NO biosynthesis
Locations in the PathwayBrowser
Summation

Nitric oxide (NO) is produced from L-arginine by the family of nitric oxide synthases (NOS) enzymes, forming the free radical NO and citrulline as byproduct. The cofactor tetrahydrobiopterin (BH4) is an essential requirement for the delivery of an electron to the intermediate in the catalytic cycle of NOS.

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
nitric-oxide synthase activity of p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] p-S1177-eNOS:CaM:HSP90:p-AKT1:BH4 [plasma membrane] nitric-oxide synthase activity (0004517)
Orthologous Events