HSP90 binds eNOS:Caveolin-1:CaM complex

Stable Identifier
R-HSA-202129
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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HSP90 binds eNOS:Caveolin-1:CaM complex
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HSP90 interacts with the amino terminus of eNOS (amino acids 442-600) and facilitates displacement of caveolin by calmodulin (CaM).
Literature References
PubMed ID Title Journal Year
9580552 Dynamic activation of endothelial nitric oxide synthase by Hsp90

Sessa, WC, Cirino, G, Garcia-Cardena, G, Sorrentino, R, Fan, R, Papapetropoulos, A, Shah, V

Nature 1998
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Output
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Catalyst Activity

nitric-oxide synthase regulator activity of HSP90AA1 [cytosol]

Physical Entity
HSP90AA1 [cytosol] (Homo sapiens)
Activity
nitric-oxide synthase regulator activity (GO:0030235)
Orthologous Events
HSP90 binds eNOS:Caveolin-1:CaM complex (Bos taurus)
HSP90 binds eNOS:Caveolin-1:CaM complex (Gallus gallus)
HSP90 binds eNOS:Caveolin-1:CaM complex (Mus musculus)
HSP90 binds eNOS:Caveolin-1:CaM complex (Rattus norvegicus)
HSP90 binds eNOS:Caveolin-1:CaM complex (Sus scrofa)
Authored
Hemish, J  (2007-10-19)
Reviewed
Enikolopov, G  (2008-02-28)
Hill, DP  (2024-08-02)
Created
Hemish, J  (2007-10-19)
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