HSP90 binds eNOS:Caveolin-1:CaM complex

Stable Identifier
R-HSA-202129
Type
Reaction
Species
Homo sapiens
Compartment
cytosol, plasma membrane
Locations in the PathwayBrowser
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Summation

HSP90 interacts with the amino terminus of eNOS (amino acids 442-600) and facilitates displacement of caveolin by calmodulin (CaM).

Literature References
PubMed ID Title Journal Year
9580552 Dynamic activation of endothelial nitric oxide synthase by Hsp90

Garcia-Cardena, G, Fan, R, Shah, V, Sorrentino, R, Cirino, G, Papapetropoulos, A, Sessa, WC

Nature 1998
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
HSP90 binds eNOS:Caveolin-1:CaM complex (Canis familiaris)
HSP90 binds eNOS:Caveolin-1:CaM complex (Mus musculus)
Authored
Hemish, J  (2007-10-19)
Reviewed
Enikolopov, G  (2008-02-28)