Phosphorylation of ZAP-70 by Lck

Stable Identifier
R-HSA-202168
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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In ZAP-70 there are multiple phosphorylation sites (Y292, Y315, Y319, Y492, Y493) which have both positive and negative regulatory effect on its catalytic activity. Tyrosine 493 is a conserved regulatory site found within the activation loop of the kinase domain. This site has shown to be a positive regulatory site required for ZAP-70 kinase activity and is phosphorylated by Lck. This phosphorylation contribute to the active conformation of the catalytic domain.

Literature References
PubMed ID Title Journal Year
8520027 The Syk/ZAP-70 protein tyrosine kinase connection to antigen receptor signalling processes

van Oers, NS, Weiss, A

Semin Immunol 1995
9850860 The Syk family of protein tyrosine kinases in T-cell activation and development

Chu, DH, Morita, CT, Weiss, A

Immunol Rev 1998
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of Antigen-bearing MHC Class II :TCR complex:CD4: Lck phosphorylated at Tyr394 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created