Reactome | p-Y113,128,145-LCP2 [cytosol]

p-Y113,128,145-LCP2 [cytosol]

Stable Identifier

R-HSA-202175

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

p-Y113,Y128,Y145-SLP-76, p-SLP-76, Lymphocyte cytosolic protein 2

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Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q13094 LCP2

Gene Names

LCP2

Chain

chain:1-533

Reference Genes

BioGPS Gene:3937 LCP2

COSMIC (genes):LCP2 LCP2

CTD Gene:3937 LCP2

dbSNP Gene:3937 LCP2

ENSEMBL:ENSG00000043462 LCP2

HGNC:6529 LCP2

KEGG Gene (Homo sapiens):3937 LCP2

Monarch:3937 LCP2

NCBI Gene:3937 LCP2

OMIM:601603 LCP2

UCSC:Q13094 LCP2

Reference Transcript

RefSeq:NM_005565.4 LCP2

Other Identifiers

0004670324

11748120_a_at

17002681

1H3H

1YWO

205269_at

205270_s_at

244251_at

244598_at

2886593

2886594

2886596

2886597

2886598

2886599

2886601

2886604

2886605

2886607

2886611

2886612

2886613

2886614

2886615

2886617

2886619

2886621

2886623

2886627

2886629

2886630

2886637

2886640

2886641

2886642

2EAP

2ROR

36396

36397

39319_at

3937

4574

79145_at

8115734

89412_at

A0A0D9SGG1

A_23_P30547

AAC50135

AAH16618

AAP35937

AK292890

BAF85579

BC016618

BT007273

CAB004574

CCDS47339

CH471062

E5RKA2

E7ESF6

EAW61479

ENSG00000043462

ENSP00000046794

ENST00000046794

ENST00000046794.9

EntrezGene:3937

EntrezGene:LCP2

g7382491_3p_a_at

GE79323

GE842618

GO:0002376

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005737

GO:0005829

GO:0005886

GO:0005911

GO:0006464

GO:0006810

GO:0006950

GO:0006955

GO:0007165

GO:0007169

GO:0008150

GO:0015031

GO:0030168

GO:0032991

GO:0035556

GO:0036398

GO:0038095

GO:0044853

GO:0045576

GO:0045860

GO:0050663

GO:0050852

HGNC:6529

HPA036396

HPA036397

Hs.137314.0.A1_3p_at

Hs.208662.0.A1_3p_at

ILMN_1658962

ILMN_1718663

IPR000980

IPR001660

IPR013761

IPR036860

LCP2

LCP2-201

MIM:601603

NM_005565

NP_005556

PF00017

PF07647

PH_hs_0000333

SM00252

SM00454

TC05002050.hg

TC05003348.hg

U20158

U20158_at

UPI000012E2AE

Participant Of

hasComponent

input

output

Syk activation leads to SLP-76 activation

This entity regulates

Positively

SLP-76 stimulates PLC gamma 2

Other forms of this molecule

LCP2 [cytosol]

Inferred To

phospho-Lcp2 [cytosol] (Mus musculus)

phospho-Lcp2 [cytosol] (Rattus norvegicus)

phospho-p-Y113,128,145-LCP2 [cytosol] (Bos taurus)

phospho-p-Y113,128,145-LCP2 [cytosol] (Canis familiaris)

phospho-p-Y113,128,145-LCP2 [cytosol] (Xenopus tropicalis)

phospho-SLP76 [cytosol] (Gallus gallus)

Ghost homologue of p-Y113,128,145-LCP2 [cytosol] (Drosophila melanogaster)

phospho-LCP2 [cytosol] (Sus scrofa)

phospho-lcp2a [cytosol] (Danio rerio)

Modified Residues

Name

O4'-phospho-L-tyrosine at 113

Coordinate

113

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 128

Coordinate

128

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 145

Coordinate

145

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_005556.1

OpenTargets

ENSG00000043462

HPA

ENSG00000043462-LCP2

GeneCards

Q13094

Ensembl

ENSG00000043462, ENST00000046794, ENSP00000046794

PRO

Q13094

PDB

2EAP, 1H3H, 2ROR, 1YWO

Interactors (22)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O75791 GRAP2	1	GRAP2 [cytosol] (R-HSA-202367)	0.974	39
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.918	18
UniProt:O15117 FYB1	1	FYB [cytosol] (R-HSA-390925)	0.904	11
UniProt:P16333 NCK1	2	NCK1 [cytosol] (R-HSA-197954) NCK1 [plasma membrane] (R-HSA-202992)	0.884	21
UniProt:O89100	1	Grap2 [cytosol] (R-MMU-202367)	0.835	7
UniProt:O43639 NCK2	1	NCK2 [cytosol] (R-HSA-204885)	0.816	10
UniProt:O75886 STAM2	2	STAM2 [cytosol] (R-HSA-182965) Ub-STAM2 [cytosol] (R-HSA-6782781)	0.788	9
UniProt:P51116 FXR2			0.781	7
UniProt:P15498 VAV1	5	p-Y174-VAV1 [cytosol] (R-HSA-437946) VAV1 [plasma membrane] (R-HSA-1045153) VAV1 [cytosol] (R-HSA-195066) p-Y142,Y160,Y174-VAV1 [plasma membrane] (R-HSA-389323) p-Y-VAV1 [cytosol] (R-HSA-9029087)	0.758	9
UniProt:Q08881 ITK	3	p-Y512-ITK [cytosol] (R-HSA-422519) p-Y180,Y512-ITK [cytosol] (R-HSA-2685616) ITK [cytosol] (R-HSA-202319)	0.734	4
UniProt:Q08379 GOLGA2	3	GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.718	6
UniProt:P62994 Grb2	3	Grb2 [plasma membrane] (R-RNO-202993) Grb2 [cytosol] (R-RNO-55929) Grb2 [cytosol] (R-RNO-74686)	0.676	3
UniProt:P00533 EGFR	59	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) EGFR [endosome membrane] (R-HSA-9611160) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.635	3
UniProt:P08487 PLCG1			0.61	5
UniProt:Q8IVH8 M4K3			0.591	5
UniProt:P06239 LCK	4	p-Y505-LCK [plasma membrane] (R-HSA-202159) p-Y394-LCK [plasma membrane] (R-HSA-8857940) p-Y394-LCK [cytosol] (R-HSA-202308) LCK [cytosol] (R-HSA-167609)	0.564	2
UniProt:P19174 PLCG1	6	p-Y771,Y783,Y1254-PLCG1 [cytosol] (R-HSA-202357) p-4Y-PLCG1 [plasma membrane] (R-HSA-167679) PLCG1 [cytosol] (R-HSA-202320) PLCG1 [plasma membrane] (R-HSA-167682) p-Y771,Y783-PLCG1 [plasma membrane] (R-HSA-1169084) p-Y-PLCG1 [cytosol] (R-HSA-9029082)	0.564	3
IntAct:EBI-22313194 CCSB ORF ID			0.556	3
UniProt:Q8TBB1 LNX1	1	LNX1 [cytosol] (R-HSA-8851641)	0.556	3
UniProt:Q9H5J4 ELOVL6	1	ELOVL6 [endoplasmic reticulum membrane] (R-HSA-548680)	0.556	3
UniProt:Q03526 Itk	4	Itk [cytosol] (R-MMU-3448705) phospho-Itk [cytosol] (R-MMU-2685616) phospho-Itk [cytosol] (R-MMU-422519) Itk [cytosol] (R-MMU-202319)	0.524	2
UniProt:P30203 CD6			0.499	3