Reactome | p-Y113,128,145-LCP2 [cytosol]

p-Y113,128,145-LCP2 [cytosol]

Stable Identifier

R-HSA-202175

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

p-Y113,Y128,Y145-SLP-76, p-SLP-76, Lymphocyte cytosolic protein 2

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Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q13094 LCP2

Gene Names

LCP2

Chain

chain:1-533

Reference Genes

BioGPS Gene:3937 LCP2

COSMIC (genes):LCP2 LCP2

CTD Gene:3937 LCP2

dbSNP Gene:3937 LCP2

ENSEMBL:ENSG00000043462 LCP2

HGNC:6529 LCP2

KEGG Gene (Homo sapiens):3937 LCP2

Monarch:3937 LCP2

NCBI Gene:3937 LCP2

OMIM:601603 LCP2

UCSC:Q13094 LCP2

Reference Transcript

RefSeq:NM_005565.4 LCP2

Other Identifiers

0004670324

11748120_a_at

17002681

205269_at

205270_s_at

244251_at

244598_at

2886593

2886594

2886596

2886597

2886598

2886599

2886601

2886604

2886605

2886607

2886611

2886612

2886613

2886614

2886615

2886617

2886619

2886621

2886623

2886627

2886629

2886630

2886637

2886640

2886641

2886642

39319_at

3937

79145_at

8115734

89412_at

A_23_P30547

GE79323

GE842618

GO:0002376

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005737

GO:0005829

GO:0005886

GO:0005911

GO:0006464

GO:0006810

GO:0006950

GO:0006955

GO:0007165

GO:0007169

GO:0007267

GO:0008150

GO:0015031

GO:0030168

GO:0032991

GO:0035556

GO:0036398

GO:0038095

GO:0044853

GO:0045576

GO:0045860

GO:0050663

GO:0050852

Hs.137314.0.A1_3p_at

Hs.208662.0.A1_3p_at

ILMN_1658962

ILMN_1718663

PH_hs_0000333

TC05002050.hg

TC05003348.hg

U20158_at

g7382491_3p_a_at

Participant Of

hasComponent

input

output

Syk activation leads to SLP-76 activation

This entity regulates

Positively

SLP-76 stimulates PLC gamma 2

Other forms of this molecule

LCP2 [cytosol]

Inferred To

phospho-Lcp2 [cytosol] (Mus musculus)

phospho-Lcp2 [cytosol] (Rattus norvegicus)

phospho-Dmel\CG15529 [cytosol] (Drosophila melanogaster)

phospho-p-Y113,128,145-LCP2 [cytosol] (Canis familiaris)

phospho-p-Y113,128,145-LCP2 [cytosol] (Gallus gallus)

phospho-p-Y113,128,145-LCP2 [cytosol] (Xenopus tropicalis)

Ghost homologue of p-Y113,128,145-LCP2 [cytosol] (Bos taurus)

phospho-LCP2 [cytosol] (Sus scrofa)

phospho-lcp2a [cytosol] (Danio rerio)

Modified Residues

Name

O4'-phospho-L-tyrosine at 113

Coordinate

113

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 128

Coordinate

128

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 145

Coordinate

145

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_005556.1

OpenTargets

ENSG00000043462

GeneCards

Q13094

HPA

ENSG00000043462-LCP2

Ensembl

ENST00000046794, ENSP00000046794, ENSG00000043462

PRO

Q13094

PDB

2EAP, 1YWO, 2ROR, 1H3H

Interactors (22)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O75791 GRAP2	1	GRAP2 [cytosol] (R-HSA-202367)	0.974	39
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.918	18
UniProt:O15117 FYB1	1	FYB [cytosol] (R-HSA-390925)	0.904	11
UniProt:P16333 NCK1	2	NCK1 [cytosol] (R-HSA-197954) NCK1 [plasma membrane] (R-HSA-202992)	0.884	21
UniProt:O89100	1	Grap2 [cytosol] (R-MMU-202367)	0.835	7
UniProt:O43639 NCK2	1	NCK2 [cytosol] (R-HSA-204885)	0.816	10
UniProt:O75886 STAM2	2	STAM2 [cytosol] (R-HSA-182965) Ub-STAM2 [cytosol] (R-HSA-6782781)	0.788	9
UniProt:P51116 FXR2			0.781	7
UniProt:P15498 VAV1	5	VAV1 [cytosol] (R-HSA-195066) VAV1 [plasma membrane] (R-HSA-1045153) p-Y174-VAV1 [cytosol] (R-HSA-437946) p-Y142,Y160,Y174-VAV1 [plasma membrane] (R-HSA-389323) p-Y-VAV1 [cytosol] (R-HSA-9029087)	0.758	9
UniProt:Q08881 ITK	3	p-Y512-ITK [cytosol] (R-HSA-422519) p-Y180,Y512-ITK [cytosol] (R-HSA-2685616) ITK [cytosol] (R-HSA-202319)	0.734	4
UniProt:Q08379 GOLGA2	3	GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-2167933) p-S37-GOLGA2 [Golgi membrane] (R-HSA-2172179) GOLGA2 [Golgi membrane] (R-HSA-6808764)	0.718	6
UniProt:P62994 Grb2	3	Grb2 [plasma membrane] (R-RNO-202993) Grb2 [cytosol] (R-RNO-55929) Grb2 [cytosol] (R-RNO-74686)	0.676	3
UniProt:P00533 EGFR	59	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) EGFR [endosome membrane] (R-HSA-9611160) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.635	3
UniProt:P08487 PLCG1			0.61	5
UniProt:Q8IVH8 M4K3			0.591	5
UniProt:P06239 LCK	4	p-Y505-LCK [plasma membrane] (R-HSA-202159) p-Y394-LCK [plasma membrane] (R-HSA-8857940) p-Y394-LCK [cytosol] (R-HSA-202308) LCK [cytosol] (R-HSA-167609)	0.564	2
UniProt:P19174 PLCG1	6	p-Y771,Y783,Y1254-PLCG1 [cytosol] (R-HSA-202357) p-4Y-PLCG1 [plasma membrane] (R-HSA-167679) PLCG1 [cytosol] (R-HSA-202320) PLCG1 [plasma membrane] (R-HSA-167682) p-Y771,Y783-PLCG1 [plasma membrane] (R-HSA-1169084) p-Y-PLCG1 [cytosol] (R-HSA-9029082)	0.564	3
IntAct:EBI-22313194 CCSB ORF ID			0.556	3
UniProt:Q8TBB1 LNX1	1	LNX1 [cytosol] (R-HSA-8851641)	0.556	3
UniProt:Q9H5J4 ELOVL6	1	ELOVL6 [endoplasmic reticulum membrane] (R-HSA-548680)	0.556	3
UniProt:Q03526 Itk	4	Itk [cytosol] (R-MMU-3448705) phospho-Itk [cytosol] (R-MMU-2685616) phospho-Itk [cytosol] (R-MMU-422519) Itk [cytosol] (R-MMU-202319)	0.524	2
UniProt:P30203 CD6			0.499	3

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