Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
p-Y113,128,145-LCP2 [cytosol]
Stable Identifier
R-HSA-202175
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
p-Y113,Y128,Y145-SLP-76, p-SLP-76, Lymphocyte cytosolic protein 2
Icon
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
GPVI-mediated activation cascade (Homo sapiens)
SLP-76 stimulates PLC gamma 2 (Homo sapiens)
p-Y113,128,145-LCP2 [cytosol] (Homo sapiens)
Syk activation leads to SLP-76 activation (Homo sapiens)
p-Y113,128,145-LCP2 [cytosol] (Homo sapiens)
p-SLP-76 binds VAV (Homo sapiens)
p-SLP-76:VAV [cytosol] (Homo sapiens)
p-Y113,128,145-LCP2 [cytosol] (Homo sapiens)
p-Y113,128,145-LCP2 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
TCR signaling (Homo sapiens)
Generation of second messenger molecules (Homo sapiens)
Disassociation of PLC-gamma1 from SLP-76 (Homo sapiens)
p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Homo sapiens)
p-Y113,128,145-LCP2 [cytosol] (Homo sapiens)
phosphorylated PLC-gamma1 bound to SLP-76 [plasma membrane] (Homo sapiens)
p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Homo sapiens)
p-Y113,128,145-LCP2 [cytosol] (Homo sapiens)
NCK binds PAK (Homo sapiens)
p-SLP-76:NCK1 [cytosol] (Homo sapiens)
p-Y113,128,145-LCP2 [cytosol] (Homo sapiens)
p-SLP-76:NCK:PAK [cytosol] (Homo sapiens)
p-SLP-76:NCK1 [cytosol] (Homo sapiens)
p-Y113,128,145-LCP2 [cytosol] (Homo sapiens)
NCK recruits WASP (Homo sapiens)
p-SLP-76:NCK1 [cytosol] (Homo sapiens)
p-Y113,128,145-LCP2 [cytosol] (Homo sapiens)
p-SLP-76:NCK1:WASP [cytosol] (Homo sapiens)
p-SLP-76:NCK1 [cytosol] (Homo sapiens)
p-Y113,128,145-LCP2 [cytosol] (Homo sapiens)
Phosphorylation of PLC-gamma1 (Homo sapiens)
PLC-gamma1 bound to LAT or SLP-76 [plasma membrane] (Homo sapiens)
PLCG1:p-3Y-SLP-76:Gads:LAT [plasma membrane] (Homo sapiens)
p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Homo sapiens)
p-Y113,128,145-LCP2 [cytosol] (Homo sapiens)
Phosphorylated PLC-gamma1 bound to LAT or SLP-76 [plasma membrane] (Homo sapiens)
phosphorylated PLC-gamma1 bound to SLP-76 [plasma membrane] (Homo sapiens)
p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Homo sapiens)
p-Y113,128,145-LCP2 [cytosol] (Homo sapiens)
ZAP-70 and ITK tyrosine kinases [plasma membrane] (Homo sapiens)
ITK:p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Homo sapiens)
p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Homo sapiens)
p-Y113,128,145-LCP2 [cytosol] (Homo sapiens)
Phosphorylation of SLP-76 (Homo sapiens)
p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Homo sapiens)
p-Y113,128,145-LCP2 [cytosol] (Homo sapiens)
Recruitment of ITK to SLP-76 (Homo sapiens)
ITK:p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Homo sapiens)
p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Homo sapiens)
p-Y113,128,145-LCP2 [cytosol] (Homo sapiens)
p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Homo sapiens)
p-Y113,128,145-LCP2 [cytosol] (Homo sapiens)
Recruitment of PLC-gamma1 to SLP-76 (Homo sapiens)
PLCG1:p-3Y-SLP-76:Gads:LAT [plasma membrane] (Homo sapiens)
p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Homo sapiens)
p-Y113,128,145-LCP2 [cytosol] (Homo sapiens)
p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane] (Homo sapiens)
p-Y113,128,145-LCP2 [cytosol] (Homo sapiens)
p-SLP-76 binds ADAP (Homo sapiens)
p-SLP-76:ADAP [cytosol] (Homo sapiens)
p-Y113,128,145-LCP2 [cytosol] (Homo sapiens)
p-Y113,128,145-LCP2 [cytosol] (Homo sapiens)
p-SLP-76 binds NCK (Homo sapiens)
p-SLP-76:NCK1 [cytosol] (Homo sapiens)
p-Y113,128,145-LCP2 [cytosol] (Homo sapiens)
p-Y113,128,145-LCP2 [cytosol] (Homo sapiens)
p-SLP-76:ADAP binds Ena/VASP (Homo sapiens)
p-SLP-76:ADAP [cytosol] (Homo sapiens)
p-Y113,128,145-LCP2 [cytosol] (Homo sapiens)
p-SLP-76:ADAP:Ena/VASP [cytosol] (Homo sapiens)
p-SLP-76:ADAP [cytosol] (Homo sapiens)
p-Y113,128,145-LCP2 [cytosol] (Homo sapiens)
Innate Immune System (Homo sapiens)
DAP12 interactions (Homo sapiens)
DAP12 signaling (Homo sapiens)
Activation of RAC1 by VAV2/3 (Homo sapiens)
p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Homo sapiens)
p-Y113,128,145-LCP2 [cytosol] (Homo sapiens)
Phosphorylation and activation of VAV2/VAV3 by SYK (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Homo sapiens)
p-Y113,128,145-LCP2 [cytosol] (Homo sapiens)
p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Homo sapiens)
p-Y113,128,145-LCP2 [cytosol] (Homo sapiens)
Phosphorylation of BTK by p-SYK (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Homo sapiens)
p-Y113,128,145-LCP2 [cytosol] (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Homo sapiens)
p-Y113,128,145-LCP2 [cytosol] (Homo sapiens)
Phosphorylation of PLC-gamma by p-BTK/p-SYK (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Homo sapiens)
p-Y113,128,145-LCP2 [cytosol] (Homo sapiens)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Homo sapiens)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Homo sapiens)
p-Y113,128,145-LCP2 [cytosol] (Homo sapiens)
p-SYK/p-BTK [plasma membrane] (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Homo sapiens)
p-Y113,128,145-LCP2 [cytosol] (Homo sapiens)
Phosphorylation of SLP-76 by p-SYK (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Homo sapiens)
p-Y113,128,145-LCP2 [cytosol] (Homo sapiens)
Recruitment of VAV and BTK to p-SLP-76 (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Homo sapiens)
p-Y113,128,145-LCP2 [cytosol] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Homo sapiens)
p-Y113,128,145-LCP2 [cytosol] (Homo sapiens)
Release of p-PLCG1 (Homo sapiens)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV [plasma membrane] (Homo sapiens)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Homo sapiens)
p-Y113,128,145-LCP2 [cytosol] (Homo sapiens)
p-5Y-LAT:GRB2:SOS:GADS:p-3Y-SLP-76:p-2Y-BTK:VAV:p-PLCG [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Homo sapiens)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Homo sapiens)
p-Y113,128,145-LCP2 [cytosol] (Homo sapiens)
Fc epsilon receptor (FCERI) signaling (Homo sapiens)
FCERI mediated Ca+2 mobilization (Homo sapiens)
Autophosphorylation of BTK/ITK (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Homo sapiens)
p-Y113,128,145-LCP2 [cytosol] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Homo sapiens)
p-Y113,128,145-LCP2 [cytosol] (Homo sapiens)
Hydrolysis of PIP2 by PLCG (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-BTK/p-2Y-ITK:PIP3 [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Homo sapiens)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Homo sapiens)
p-Y113,128,145-LCP2 [cytosol] (Homo sapiens)
Phosphorylation of PLC-gamma (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-BTK/p-2Y-ITK:PIP3 [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:p-PLCG [plasma membrane] (Homo sapiens)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Homo sapiens)
p-Y113,128,145-LCP2 [cytosol] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Homo sapiens)
p-Y113,128,145-LCP2 [cytosol] (Homo sapiens)
p-SYK/p-BTK [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Homo sapiens)
p-Y113,128,145-LCP2 [cytosol] (Homo sapiens)
Phosphorylation of TEC kinases by p-SYK (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:TEC kinases:PIP3 [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Homo sapiens)
p-Y113,128,145-LCP2 [cytosol] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Homo sapiens)
p-Y113,128,145-LCP2 [cytosol] (Homo sapiens)
Recruitment of TEC kinases to p-SLP-76 (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Homo sapiens)
p-Y113,128,145-LCP2 [cytosol] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:TEC kinases:PIP3 [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Homo sapiens)
p-Y113,128,145-LCP2 [cytosol] (Homo sapiens)
FCERI mediated MAPK activation (Homo sapiens)
Activation of RAC1 by VAV (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Homo sapiens)
p-Y113,128,145-LCP2 [cytosol] (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Homo sapiens)
p-Y113,128,145-LCP2 [cytosol] (Homo sapiens)
Autophosphorylation of PAK (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Homo sapiens)
p-Y113,128,145-LCP2 [cytosol] (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Homo sapiens)
p-Y113,128,145-LCP2 [cytosol] (Homo sapiens)
Phosphorylation and activation of VAV (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Homo sapiens)
p-Y113,128,145-LCP2 [cytosol] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Homo sapiens)
p-Y113,128,145-LCP2 [cytosol] (Homo sapiens)
Phosphorylation of SLP-76 by p-SYK (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Homo sapiens)
p-Y113,128,145-LCP2 [cytosol] (Homo sapiens)
Recruitment of PAK to the membrane by binding active RAC1 (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Homo sapiens)
p-Y113,128,145-LCP2 [cytosol] (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP:PAK dimer [plasma membrane] (Homo sapiens)
p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Homo sapiens)
p-Y113,128,145-LCP2 [cytosol] (Homo sapiens)
Recruitment of VAV to p-SLP-76 (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Homo sapiens)
p-Y113,128,145-LCP2 [cytosol] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] (Homo sapiens)
p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] (Homo sapiens)
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] (Homo sapiens)
p-Y113,128,145-LCP2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13094 LCP2
Gene Names
LCP2
Chain
chain:1-533
Reference Genes
BioGPS Gene:3937 LCP2
COSMIC (genes):LCP2 LCP2
CTD Gene:3937 LCP2
dbSNP Gene:3937 LCP2
ENSEMBL:ENSG00000043462 LCP2
HGNC:6529 LCP2
KEGG Gene (Homo sapiens):3937 LCP2
Monarch:3937 LCP2
NCBI Gene:3937 LCP2
OMIM:601603 LCP2
UCSC:Q13094 LCP2
Reference Transcript
RefSeq:NM_005565.4 LCP2
Other Identifiers
0004670324
11748120_a_at
17002681
205269_at
205270_s_at
244251_at
244598_at
2886593
2886594
2886596
2886597
2886598
2886599
2886601
2886604
2886605
2886607
2886611
2886612
2886613
2886614
2886615
2886617
2886619
2886621
2886623
2886627
2886629
2886630
2886637
2886640
2886641
2886642
39319_at
3937
79145_at
8115734
89412_at
A_23_P30547
GE79323
GE842618
GO:0002376
GO:0003674
GO:0005515
GO:0005575
GO:0005622
GO:0005737
GO:0005829
GO:0005886
GO:0005911
GO:0006464
GO:0006810
GO:0006950
GO:0006955
GO:0007165
GO:0007169
GO:0007267
GO:0008150
GO:0015031
GO:0030168
GO:0032991
GO:0035556
GO:0036398
GO:0038095
GO:0044853
GO:0045576
GO:0045860
GO:0050663
GO:0050852
Hs.137314.0.A1_3p_at
Hs.208662.0.A1_3p_at
ILMN_1658962
ILMN_1718663
PH_hs_0000333
TC05002050.hg
TC05003348.hg
U20158_at
g7382491_3p_a_at
Participant Of
hasComponent
GADS:p-Y113,Y128,Y145-SLP-76 [cytosol]
p-SLP-76:ADAP [cytosol]
p-SLP-76:NCK1 [cytosol]
p-SLP-76:VAV [cytosol]
p-Y113,128,145-SLP-76:GADS:LAT [plasma membrane]
input
p-SLP-76 binds ADAP
p-SLP-76 binds NCK
p-SLP-76 binds VAV
output
Syk activation leads to SLP-76 activation
This entity regulates
Positively
SLP-76 stimulates PLC gamma 2
Other forms of this molecule
LCP2 [cytosol]
Inferred To
phospho-Lcp2 [cytosol] (Mus musculus)
phospho-Lcp2 [cytosol] (Rattus norvegicus)
phospho-Dmel\CG15529 [cytosol] (Drosophila melanogaster)
phospho-p-Y113,128,145-LCP2 [cytosol] (Canis familiaris)
phospho-p-Y113,128,145-LCP2 [cytosol] (Gallus gallus)
phospho-p-Y113,128,145-LCP2 [cytosol] (Xenopus tropicalis)
Ghost homologue of p-Y113,128,145-LCP2 [cytosol] (Bos taurus)
phospho-LCP2 [cytosol] (Sus scrofa)
phospho-lcp2a [cytosol] (Danio rerio)
Modified Residues
Name
O4'-phospho-L-tyrosine at 113
Coordinate
113
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 128
Coordinate
128
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 145
Coordinate
145
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_005556.1
OpenTargets
ENSG00000043462
GeneCards
Q13094
HPA
ENSG00000043462-LCP2
Ensembl
ENST00000046794
,
ENSG00000043462
,
ENSP00000046794
PRO
Q13094
PDB
1YWO
,
2EAP
,
1H3H
,
2ROR
Interactors (22)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O75791 GRAP2
1
GRAP2 [cytosol]
(R-HSA-202367)
0.975
40
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.918
18
UniProt:O15117 FYB1
1
FYB [cytosol]
(R-HSA-390925)
0.904
11
UniProt:P16333 NCK1
2
NCK1 [cytosol]
(R-HSA-197954)
NCK1 [plasma membrane]
(R-HSA-202992)
0.884
21
UniProt:O89100
1
Grap2 [cytosol]
(R-MMU-202367)
0.835
7
UniProt:O43639 NCK2
1
NCK2 [cytosol]
(R-HSA-204885)
0.816
10
UniProt:O75886 STAM2
2
STAM2 [cytosol]
(R-HSA-182965)
Ub-STAM2 [cytosol]
(R-HSA-6782781)
0.788
9
UniProt:P51116 FXR2
0.781
7
UniProt:P15498 VAV1
5
VAV1 [cytosol]
(R-HSA-195066)
VAV1 [plasma membrane]
(R-HSA-1045153)
p-Y174-VAV1 [cytosol]
(R-HSA-437946)
p-Y142,Y160,Y174-VAV1 [plasma membrane]
(R-HSA-389323)
p-Y-VAV1 [cytosol]
(R-HSA-9029087)
0.758
9
UniProt:Q08881 ITK
3
p-Y512-ITK [cytosol]
(R-HSA-422519)
p-Y180,Y512-ITK [cytosol]
(R-HSA-2685616)
ITK [cytosol]
(R-HSA-202319)
0.734
4
UniProt:Q08379 GOLGA2
3
GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-2167933)
p-S37-GOLGA2 [Golgi membrane]
(R-HSA-2172179)
GOLGA2 [Golgi membrane]
(R-HSA-6808764)
0.718
6
UniProt:P62994 Grb2
3
Grb2 [plasma membrane]
(R-RNO-202993)
Grb2 [cytosol]
(R-RNO-55929)
Grb2 [cytosol]
(R-RNO-74686)
0.676
3
UniProt:P00533 EGFR
59
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
p-6Y-EGFR A289V [plasma membrane]
(R-HSA-1996334)
p-6Y-EGFR T263P [plasma membrane]
(R-HSA-1996336)
p-6Y-EGFR G598V [plasma membrane]
(R-HSA-1996339)
p-6Y-EGFR R108K [plasma membrane]
(R-HSA-1996338)
p-6Y-EGFR A289T [plasma membrane]
(R-HSA-1996341)
p-6Y-EGFR G719C [plasma membrane]
(R-HSA-1177530)
p-6Y-EGFR A289D [plasma membrane]
(R-HSA-1996340)
p-6Y-EGFR G719A [plasma membrane]
(R-HSA-1177528)
EGFR L858R;T790M [plasma membrane]
(R-HSA-1181386)
EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1181399)
EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996322)
EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996325)
EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996326)
EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996317)
EGFR L858R [plasma membrane]
(R-HSA-1173212)
EGFR G719S [plasma membrane]
(R-HSA-1169418)
EGFR E746_A750del [plasma membrane]
(R-HSA-1181211)
EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228010)
EGFR A289V [plasma membrane]
(R-HSA-1996321)
EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228012)
EGFR L747_T751del [plasma membrane]
(R-HSA-1228015)
EGFR A289D [plasma membrane]
(R-HSA-1996327)
EGFR L861Q [plasma membrane]
(R-HSA-1177542)
EGFR R108K [plasma membrane]
(R-HSA-1996330)
EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228034)
EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228031)
EGFR G719A [plasma membrane]
(R-HSA-1177532)
EGFR A289T [plasma membrane]
(R-HSA-1996306)
EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228025)
EGFR G719C [plasma membrane]
(R-HSA-1177531)
EGFR T263P [plasma membrane]
(R-HSA-1996315)
EGFR G598V [plasma membrane]
(R-HSA-1996314)
EGFR L747_S752del [plasma membrane]
(R-HSA-1228016)
EGFR [endosome membrane]
(R-HSA-9611160)
p-4Y-EGFR [plasma membrane]
(R-HSA-180287)
p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane]
(R-HSA-8864019)
p-Y1086,Y1101-EGFR [plasma membrane]
(R-HSA-179868)
EGFR [plasma membrane]
(R-HSA-179837)
p-6Y-EGFR [plasma membrane]
(R-HSA-179803)
0.635
3
UniProt:P08487 PLCG1
0.61
5
UniProt:Q8IVH8 M4K3
0.591
5
UniProt:P06239 LCK
4
p-Y505-LCK [plasma membrane]
(R-HSA-202159)
p-Y394-LCK [plasma membrane]
(R-HSA-8857940)
p-Y394-LCK [cytosol]
(R-HSA-202308)
LCK [cytosol]
(R-HSA-167609)
0.564
2
UniProt:P19174 PLCG1
6
p-Y771,Y783,Y1254-PLCG1 [cytosol]
(R-HSA-202357)
p-4Y-PLCG1 [plasma membrane]
(R-HSA-167679)
PLCG1 [cytosol]
(R-HSA-202320)
PLCG1 [plasma membrane]
(R-HSA-167682)
p-Y771,Y783-PLCG1 [plasma membrane]
(R-HSA-1169084)
p-Y-PLCG1 [cytosol]
(R-HSA-9029082)
0.564
3
IntAct:EBI-22313194 CCSB ORF ID
0.556
3
UniProt:Q8TBB1 LNX1
1
LNX1 [cytosol]
(R-HSA-8851641)
0.556
3
UniProt:Q9H5J4 ELOVL6
1
ELOVL6 [endoplasmic reticulum membrane]
(R-HSA-548680)
0.556
3
UniProt:Q03526 Itk
4
Itk [cytosol]
(R-MMU-3448705)
phospho-Itk [cytosol]
(R-MMU-2685616)
phospho-Itk [cytosol]
(R-MMU-422519)
Itk [cytosol]
(R-MMU-202319)
0.524
2
UniProt:P30203 CD6
0.499
3
© 2021
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text