Reactome | Dermatan-sulfate epimerase (DSE) converts chondroitin sulfate (CS) to dermatan sulfate (DS)

Dermatan-sulfate epimerase (DSE) converts chondroitin sulfate (CS) to dermatan sulfate (DS)

Stable Identifier

R-HSA-2022052

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi membrane, Golgi lumen

ReviewStatus

5/5

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Dermatan-sulfate epimerase (DSE) converts chondroitin sulfate (CS) to dermatan sulfate (DS)

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The glucuronate (GlcA) moiety of chondroitin sulfate (CS) can undergo C-5 epimerization to change into an iduronic acid (IdoA) moiety, thus changing the polymer composition and creating dermatan sulfate (DS). The GlcA of unsulfated chondroitin chains can also undergo this C-5 epimerization to produce dermatan. Dermatan-sulfate epimerase (DSE) mediates these reactions (Tiedemann et al. 2001). More recently, a single homologue of DSE, dermatan sulfate epimerase-like (DSEL), has been determined to possess epimerase activity (Pacheco et al. 2009). DSEL is genetically associated with type II bipolar disorder (Goossens et al. 2003).

Literature References

PubMed ID	Title	Journal	Year
11414686	The glucuronyl C5-epimerase activity is the limiting factor in the dermatan sulfate biosynthesis Larsson, T, Tiedemann, K, Malmström, A, Heinegård, D	Arch Biochem Biophys	2001
19188366	Two dermatan sulfate epimerases form iduronic acid domains in dermatan sulfate Pacheco, B, Malmström, A, Maccarana, M	J. Biol. Chem.	2009
16505484	Biosynthesis of dermatan sulfate: chondroitin-glucuronate C5-epimerase is identical to SART2 Aebersold, R, Maccarana, M, Li, JP, Malmström, J, Tiedemann, K, Olander, B, Malmström, A, Lindahl, U	J Biol Chem	2006
12556911	A novel CpG-associated brain-expressed candidate gene for chromosome 18q-linked bipolar disorder Backhovens, H, Claes, S, Van Broeckhoven, C, Van den Bossche, D, Mendlewicz, J, Van Gestel, S, Massat, I, De Rijk, P, Del-Favero, J, Goossens, D, Souery, D	Mol. Psychiatry	2003