Reactome: A Curated Pathway Database

Prolysyl oxidase activation

Stable Identifier
R-HSA-2022141
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Lysyl oxidase (LOX) is secreted to the extracellular space in an inactive, proenzyme form (proLOX). This is proteolytically cleaved between Gly168 and Asp169 generating the mature 32-kDa enzyme. The activating proteinase is Bone morphogenetic protein 1 (BMP1), also called Procollagen C-proteinase (Cronshaw et al. 1995, Panchenko et al. 1996). Other extracellular proteases, including the BMP1 variant mammalian tolloid, tolloid-like (TLL) 1 and TLL2 proteases cleave proLOX at the correct physiological site but with lower efficiency (Uzel et al. 2001).

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
metalloendopeptidase activity of Procollagen C-proteinases [extracellular region] Procollagen C-proteinases [extracellular region] metalloendopeptidase activity (0004222)
Orthologous Events