Phosphorylation of SLP-76

Stable Identifier
R-HSA-202216
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
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Once SLP-76 is recruited to Gads its rapidly phosphorylated on the tyrosine residues in the N-terminal acidic domain. This domain contains three tyrosine phosphorylation sites, Y113, Y128 and Y145. These tyrosine residues are phosphorylated by tyrosine kinase ZAP-70 and these phosphorylated tyrosine residues provide the binding site for the SH2 domains of the incoming signaling proteins like Vav, Itk and PLC-gamma1.

Literature References
PubMed ID Title Journal Year
17652306 Keeping the (kinase) party going: SLP-76 and ITK dance to the beat

Qi, Q, August, A

Sci STKE 2007
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of Activated ZAP-70 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created