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ACE2(18-805) [plasma membrane]
Stable Identifier
R-HSA-2022344
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
ACE2, Angiotensin-converting enzyme 2, ACE2_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Peptide hormone metabolism (Homo sapiens)
Metabolism of Angiotensinogen to Angiotensins (Homo sapiens)
ACE2 hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9) (Homo sapiens)
ACE2(18-805) [plasma membrane] (Homo sapiens)
ACE2 hydrolyzes Angiotensin-(1-8) to Angiotensin-(1-7) (Homo sapiens)
ACE2(18-805) [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9BYF1 ACE2
Gene Names
ACE2, UNQ868/PRO1885
Chain
signal peptide:1-17, chain:18-805, chain:18-708
Reference Genes
BioGPS Gene:59272 ACE2
COSMIC (genes):ACE2 ACE2
CTD Gene:59272 ACE2
dbSNP Gene:59272 ACE2
ENSEMBL:ENSG00000130234 ACE2
HGNC:13557 ACE2
KEGG Gene (Homo sapiens):59272 ACE2
Monarch:59272 ACE2
NCBI Gene:59272 ACE2
OMIM:300335 ACE2
Other Identifiers
0006590519
11725624_at
11725625_s_at
11725626_a_at
17109301
219962_at
222257_s_at
4000606
4000607
4000608
4000609
4000611
4000612
4000615
4000616
4000617
4000618
4000619
4000621
4000623
4000624
4000625
4000626
4000627
4000628
4000629
4000630
4000631
4000632
4000633
4000634
4000635
4000636
4000637
4000638
4000640
51620_at
59272
8171449
A_23_P252981
GE56434
GO:0001618
GO:0001817
GO:0002003
GO:0003013
GO:0003051
GO:0003081
GO:0003674
GO:0004175
GO:0004180
GO:0004181
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005737
GO:0005886
GO:0006508
GO:0006810
GO:0006950
GO:0008150
GO:0008233
GO:0008237
GO:0008241
GO:0008270
GO:0008283
GO:0009058
GO:0009986
GO:0015827
GO:0016020
GO:0016021
GO:0016032
GO:0016324
GO:0016787
GO:0019229
GO:0022607
GO:0022898
GO:0031526
GO:0032800
GO:0034330
GO:0034641
GO:0042127
GO:0043167
GO:0043226
GO:0044403
GO:0045121
GO:0046718
GO:0046813
GO:0046872
GO:0050727
GO:0050877
GO:0051604
GO:0051957
GO:0055085
GO:0060452
GO:0070062
GO:0097746
GO:1903598
GO:1903779
GO:1905737
GO:2000379
ILMN_1667018
PH_hs_0010582
TC0X000878.hg
g11225608_3p_a_at
Other forms of this molecule
ACE2 [endocytic vesicle membrane]
glycosylated-ACE2 [endocytic vesicle membrane]
glycosylated-ACE2 [plasma membrane]
ACE2 [endoplasmic reticulum lumen]
Inferred To
Homologues of ACE2(18-805) [plasma membrane] (Drosophila melanogaster)
Ance-5 [plasma membrane] (Drosophila melanogaster)
Ance-3 [plasma membrane] (Drosophila melanogaster)
ace2 [plasma membrane] (Danio rerio)
ace2 [plasma membrane] (Xenopus tropicalis)
Acer [plasma membrane] (Drosophila melanogaster)
Ance-2 [plasma membrane] (Drosophila melanogaster)
ACE2 [plasma membrane] (Canis familiaris)
ACE2 [plasma membrane] (Sus scrofa)
Ace2 [plasma membrane] (Mus musculus)
Ace2 [plasma membrane] (Rattus norvegicus)
Ance [plasma membrane] (Drosophila melanogaster)
acn-1 [plasma membrane] (Caenorhabditis elegans)
Ance-4 [plasma membrane] (Drosophila melanogaster)
Cross References
ZINC - Investigational
ACE2_HUMAN
OpenTargets
ENSG00000130234
ZINC - Substances
ACE2_HUMAN
HPA
ENSG00000130234-ACE2
GeneCards
Q9BYF1
Ensembl
ENST00000427411
,
ENSP00000252519
,
ENSG00000130234
,
ENST00000252519
,
ENSP00000389326
ZINC target
Q9BYF1
PRO
Q9BYF1
ZINC - Predictions - Purchasable
ACE2_HUMAN
HMDB Protein
HMDBP08177
PDB
6ACJ
,
3SCK
,
3KBH
,
6VW1
,
3D0G
,
6M18
,
3SCJ
,
6M0J
,
3D0H
,
6M17
,
1XJP
,
3SCI
,
6ACG
,
3D0I
,
6CS2
,
2AJF
,
6LZG
,
3SCL
,
1R4L
,
6ACK
,
1R42
,
6M1D
Interactors (17)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P0DTC2 S
16
tri-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9697006)
fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9696997)
di-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9696920)
high-mannose N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9696943)
nascent Spike [endoplasmic reticulum lumen]
(R-COV-9694796)
14-sugar N-glycan unfolded Spike [endoplasmic reticulum lumen]
(R-COV-9694459)
Man(9) N-glycan unfolded Spike [endoplasmic reticulum lumen]
(R-COV-9696892)
high-mannose N-glycan unfolded Spike [endoplasmic reticulum lumen]
(R-COV-9696875)
high-mannose N-glycan folded Spike [endoplasmic reticulum lumen]
(R-COV-9696880)
high-mannose N-glycan-PALM-Spike [endoplasmic reticulum lumen]
(R-COV-9696917)
complex N-glycan-PALM-Spike S2 Fragment [endocytic vesicle membrane]
(R-COV-9694343)
complex N-glycan-PALM-Spike S1 Fragment [endocytic vesicle membrane]
(R-COV-9694745)
complex N-glycan-PALM-Spike S1 Fragment [virion membrane]
(R-COV-9694638)
complex N-glycan-PALM-Spike S2 Fragment [virion membrane]
(R-COV-9694791)
fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9698330)
fully glycosylated Spike [virion membrane]
(R-COV-9698327)
0.991
84
UniProt:P59594 S
12
complex N-glycan-PALM-Spike S1 Fragment [endocytic vesicle membrane]
(R-COV-9686693)
complex N-glycan-PALM-Spike S2 Fragment [endocytic vesicle membrane]
(R-COV-9686730)
complex N-glycan-PALM-Spike S1 Fragment [virion membrane]
(R-COV-9686706)
complex N-glycan-PALM-Spike S2 Fragment [virion membrane]
(R-COV-9686724)
nascent Spike [endoplasmic reticulum lumen]
(R-COV-9682868)
N-glycan Spike [endoplasmic reticulum lumen]
(R-COV-9683594)
trimmed unfolded N-glycan Spike [endoplasmic reticulum lumen]
(R-COV-9683716)
trimmed N-glycan Spike [endoplasmic reticulum lumen]
(R-COV-9683608)
trimmed N-glycan-PALM-Spike [endoplasmic reticulum lumen]
(R-COV-9683638)
trimmed N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9683657)
complex N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9683617)
complex N-glycan-PALM-Spike [virion membrane]
(R-COV-9685469)
0.986
46
UniProt:Q6Q1S2 SPIKE
0.817
8
UniProt:P01042-PRO_0000006688 KNG1
0.73
5
UniProt:P59594-PRO_0000037209 S
0.713
3
IntAct:EBI-25504301 PEPTIDE-MCA-YVADAPK-DNP
0.623
8
UniProt:P30990-PRO_0000019524 NTS
0.623
2
UniProt:Q01523-PRO_0000417390 DEFA5
0.623
4
UniProt:P01019-PRO_0000032457 AGT
0.623
2
UniProt:P01019-PRO_0000032458 AGT
0.623
5
UniProt:Q9BYF1 ACE2
5
ACE2 [endocytic vesicle membrane]
(R-HSA-9698958)
ACE2(18-805) [plasma membrane]
(R-HSA-2022344)
glycosylated-ACE2 [endocytic vesicle membrane]
(R-HSA-9686721)
glycosylated-ACE2 [plasma membrane]
(R-HSA-9683480)
ACE2 [endoplasmic reticulum lumen]
(R-HSA-9683474)
0.573
5
UniProt:P05556 ITGB1
2
ITGB1 [endosome membrane]
(R-HSA-9611157)
ITGB1 [plasma membrane]
(R-HSA-57596)
0.57
4
sphingosine [ChEBI:16393]
6
SPG [Golgi membrane]
(R-ALL-428248)
SPG [lysosomal lumen]
(R-ALL-1606588)
SPG [extracellular region]
(R-ALL-428662)
SPG [cytosol]
(R-ALL-428682)
SPG [endoplasmic reticulum membrane]
(R-ALL-428193)
SPG [plasma membrane]
(R-ALL-1606609)
0.544
4
UniProt:Q5GDB5 Q5GDB5
0.524
2
UniProt:Q695T7 SLC6A19
6
SLC6A19 V295Afs*57 [plasma membrane]
(R-HSA-5659736)
SLC6A19 [plasma membrane]
(R-HSA-375483)
SLC6A19 D173N [plasma membrane]
(R-HSA-5659723)
SLC6A19 I596Hfs*73 [plasma membrane]
(R-HSA-5659728)
SLC6A19 S303L [plasma membrane]
(R-HSA-5659746)
SLC6A19 R240* [plasma membrane]
(R-HSA-5659732)
0.488
3
UniProt:O15393 TMPRSS2
2
TMPRSS2 [plasma membrane]
(R-HSA-9686707)
TMPRSS2 [extracellular region]
(R-HSA-9681528)
0.463
3
UniProt:P37173 TGFBR2
9
TGFBR2 E526Q [plasma membrane]
(R-HSA-3645770)
TGFBR2 Y470D [plasma membrane]
(R-HSA-3640905)
TGFBR2 D522N [plasma membrane]
(R-HSA-3640907)
TGFBR2 R528H [plasma membrane]
(R-HSA-3640894)
TGFBR2 R528C [plasma membrane]
(R-HSA-3640899)
TGFBR2 K128fs*3 [cytosol]
(R-HSA-3642173)
TGFBR2 K128fs*35 [cytosol]
(R-HSA-3642166)
NEDD8-K556,K567-TGFBR2 [plasma membrane]
(R-HSA-4332222)
TGFBR2 [plasma membrane]
(R-HSA-170842)
0.463
2
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