Neprilysin hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7)

Stable Identifier
R-HSA-2022368
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region, plasma membrane
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Neprilysin hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7)
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Neprilysin hydrolyzes angiotensin-(1-9) to yield angiotensin-(1-7) (Rice et al. 2004). The hydrolysis of angiotensin-(1-9) catalyzed by neprilysin is more efficient than that catalyzed by angiotensin-converting enzyme (ACE) (Rice et al. 2004).

Literature References
PubMed ID Title Journal Year
15283675 Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism

Rice, GI, Thomas, DA, Grant, PJ, Turner, AJ, Hooper, NM

Biochem J 2004
Participants
Input
Output
Participant Of
hasEvent
Event Information
Go Biological Process
angiotensin maturation (0002003)
Catalyst Activity
Catalyst Activity
Title
metallopeptidase activity of MME [plasma membrane]
Physical Entity
MME [plasma membrane]
Activity
metallopeptidase activity (0008237)
Orthologous Events
Neprilysin hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7) (Canis familiaris)
Neprilysin hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7) (Drosophila melanogaster)
Neprilysin hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7) (Mus musculus)
Neprilysin hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7) (Rattus norvegicus)
Neprilysin hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7) (Xenopus tropicalis)
Authored
May, B  (2011-11-19)
Reviewed
Joseph, J  (2012-08-06)
Created
May, B  (2011-11-29)