Neprilysin hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7)

Stable Identifier
R-HSA-2022368
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Neprilysin hydrolyzes angiotensin-(1-9) to yield angiotensin-(1-7) (Rice et al. 2004). The hydrolysis of angiotensin-(1-9) catalyzed by neprilysin is more efficient than that catalyzed by angiotensin-converting enzyme (ACE) (Rice et al. 2004).

Literature References
PubMed ID Title Journal Year
15283675 Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism

Rice, GI, Thomas, DA, Grant, PJ, Turner, AJ, Hooper, NM

Biochem J 2004
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Catalyst Activity
Title
metallopeptidase activity of MME [plasma membrane]
Physical Entity
Activity
Orthologous Events
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