Hydrolysis of PIP3 to PI(3,4)P2

Stable Identifier
R-HSA-202237
Type
Reaction
Species
Homo sapiens
Compartment
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After the generation of PIP3 by PI3K, a part of it is further dephosphorylated to generate other forms of PI which are also involved in signaling. Two major routes for the degradation of PIP3 exists: dephosphorylation by the haematopoietic-specific SH2 domain-containing inositol 5' phosphatase SHIP-1 and dephosphorylation by the 3' phosphoinositide phosphatase PTEN.
SHIP-1 appears to set an activation threshold on T cell signaling. SHIP-1 phosphatase activity removes the 5' phosphate of PIP3 and generate phosphatidylinositol 3,4-bisphosphate. PI(3,4)P2 along with PIP3 preferentially binds to the PH domains of PKB and PDK1.

Literature References
PubMed ID Title Journal Year
10716940 Structure, function, and biology of SHIP proteins

Rohrschneider, LR, Fuller, JF, Wolf, I, Liu, Y, Lucas, DM

Genes Dev 2000
11884229 Regulation of the immune response by SHIP

March, ME, Ravichandran, K

Semin Immunol 2002
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity of INPP5D [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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