Angiotensin-converting enzyme 2 (ACE2) hydrolyzes angiotensin-(1-10) (angiotensin I) to yield angiotensin-(1-9) (Donoghue et al. 2000, Tipnis et al. 2000, Vickers et al. 2002, Rice t al. 2004). The activity of ACE2 on angiotensin I is weak (Rice et al. 2004), being 400-fold lower than the activity of ACE2 on angiotensin II (Vickers et al. 2002).
Rice, GI, Thomas, DA, Grant, PJ, Turner, AJ, Hooper, NM
Vickers, C, Hales, P, Kaushik, V, Dick, L, Gavin, J, Tang, J, Godbout, K, Parsons, T, Baronas, E, Hsieh, F, Acton, S, Patane, M, Nichols, A, Tummino, P
Tipnis, SR, Hooper, NM, Hyde, R, Karran, E, Christie, G, Turner, AJ
Donoghue, M, Hsieh, F, Baronas, E, Godbout, K, Gosselin, M, Stagliano, N, Donovan, M, Woolf, B, Robison, K, Jeyaseelan, R, Breitbart, RE, Acton, S
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