ACE2 hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9)

Stable Identifier
Reaction [transition]
Homo sapiens
ACE2 Hydrolyzes Angiotensin I to Yield Angiotensin-(1-9)
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Angiotensin-converting enzyme 2 (ACE2) hydrolyzes angiotensin-(1-10) (angiotensin I) to yield angiotensin-(1-9) (Donoghue et al. 2000, Tipnis et al. 2000, Vickers et al. 2002, Rice t al. 2004). The activity of ACE2 on angiotensin I is weak (Rice et al. 2004), being 400-fold lower than the activity of ACE2 on angiotensin II (Vickers et al. 2002).

Literature References
PubMed ID Title Journal Year
15283675 Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism

Rice, GI, Thomas, DA, Grant, PJ, Turner, AJ, Hooper, NM

Biochem J 2004
11815627 Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase

Vickers, C, Hales, P, Kaushik, V, Dick, L, Gavin, J, Tang, J, Godbout, K, Parsons, T, Baronas, E, Hsieh, F, Acton, S, Patane, M, Nichols, A, Tummino, P

J Biol Chem 2002
10924499 A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase

Tipnis, SR, Hooper, NM, Hyde, R, Karran, E, Christie, G, Turner, AJ

J Biol Chem 2000
10969042 A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9

Donoghue, M, Hsieh, F, Baronas, E, Godbout, K, Gosselin, M, Stagliano, N, Donovan, M, Woolf, B, Robison, K, Jeyaseelan, R, Breitbart, RE, Acton, S

Circ Res 2000
Participant Of
Event Information
Go Biological Process
Catalyst Activity
Catalyst Activity
metallocarboxypeptidase activity of ACE2(18-805) [plasma membrane]
Physical Entity
Orthologous Events
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