Reactome | ACE2 hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9)

ACE2 hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9)

Stable Identifier

R-HSA-2022378

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

Synonyms

ACE2 Hydrolyzes Angiotensin I to Yield Angiotensin-(1-9)

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

ACE2 hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9)

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Angiotensin-converting enzyme 2 (ACE2) hydrolyzes angiotensin-(1-10) (angiotensin I) to yield angiotensin-(1-9) (Donoghue et al. 2000, Tipnis et al. 2000, Vickers et al. 2002, Rice t al. 2004). The activity of ACE2 on angiotensin I is weak (Rice et al. 2004), being 400-fold lower than the activity of ACE2 on angiotensin II (Vickers et al. 2002).

Literature References

PubMed ID	Title	Journal	Year
11815627	Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase Gavin, J, Vickers, C, Nichols, A, Acton, S, Patane, M, Godbout, K, Kaushik, V, Hales, P, Tang, J, Hsieh, F, Parsons, T, Tummino, P, Baronas, E, Dick, L	J Biol Chem	2002
15283675	Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism Hooper, NM, Turner, AJ, Grant, PJ, Thomas, DA, Rice, GI	Biochem J	2004
10924499	A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase Turner, AJ, Hooper, NM, Karran, E, Hyde, R, Christie, G, Tipnis, SR	J Biol Chem	2000
10969042	A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9 Godbout, K, Breitbart, RE, Gosselin, M, Donovan, M, Robison, K, Jeyaseelan, R, Stagliano, N, Acton, S, Hsieh, F, Donoghue, M, Woolf, B, Baronas, E	Circ Res	2000